Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam

Biochemical Pharmacology

Volumn 55, Issue 6, 1998, Pages 889-896

  Yang, Tian J ^a   Shou, Magang ^b   Korzekwa, Kenneth R ^d   Gonzalez, Frank J ^c   Gelboin, Harry V ^c   Yang, Shen K ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

cDNA expression; Cytochrome P450; Diazepam metabolism; High performance liquid chromatography; Human liver microsomes

Indexed keywords

CYTOCHROME P450; DIAZEPAM; NORDAZEPAM; TEMAZEPAM;

AEROBIC METABOLISM; ARTICLE; DEMETHYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER METABOLISM; LIVER MICROSOME; MOLECULAR CLONING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; KINETICS; LINEAR MODELS; MICROSOMES, LIVER; NORDAZEPAM; TEMAZEPAM;

EID: 0032520746     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00558-3     Document Type: Article

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