Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations

Journal of General Virology

Volumn 82, Issue 6, 2001, Pages 1263-1272

  Nielsen, H S ^a   Oleksiewicz, M B ^a   Forsberg, R ^a   Stadejek, T ^a   Botner A ^a   Storgaard, T ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE PROTEINASE; HELICASE; PAPAIN; VIRUS VACCINE;

ADAPTATION; ARTERIVIRUS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE MUTATION; GENE SEQUENCE; GENETIC CONSERVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERTANT; SWINE; VIRUS ATTENUATION; VIRUS ISOLATION; VIRUS TRANSMISSION;

EID: 0034991023     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-82-6-1263     Document Type: Article

References (43)

1. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions
2. Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype
3. Appearance of acute PRRS-like symptoms in sow herds after vaccination with a modified live PRRS vaccine
4. Heterologous challenge with porcine reproductive and respiratory syndrome (PRRS) vaccine virus: No evidence of reactivation of previous European-type PRRS virus infection
5. Characterization of field isolates of suid herpesvirus 1 (Aujeszky's disease virus) as derivatives of attenuated vaccine strains
6. RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence
7. Aseptic meningitis after vaccination against measles and mumps
8. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs
9. Evolutionary reversals during viral adaptation to alternating hosts
10. Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: Identification of two papainlike cysteine proteases
11. Simple diagnostic statistical tests of models for DNA substitution
12. A codon-based model of nucleotide substitution for protein-coding DNA sequences
13. Helicases: Amino acid sequence comparisons and structure-function relationships
14. Amino acid difference formula to help explain protein evolution
15. Dating of the human-ape splitting by a molecular clock of mitochondrial DNA
16. Cn3D: A new generation of three-dimensional molecular structure viewer
17. Transmission of varicella to a gravida via close contacts immunized with varicella-zoster vaccine: A case report
18. Virus-encoded RNA helicases
19. Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5′-noncoding region and the E2 envelope glycoprotein
20. Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP
21. Sequence analysis of porcine reproductive and respiratory syndrome virus of the American type collected from Danish swine herds
22. Comparison among strains of porcine reproductive and respiratory syndrome virus for their ability to cause reproductive failure
23. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV
24. Attenuation and reversion of the Sabin vaccine strains of poliovirus
25. Molecular biology and the control of viral vaccines
26. Adverse effects of the Ingelvac™ PRRS modified live vaccine on sow productivity in herds infected with porcine reproductive and respiratory syndrome virus
27. Porcine reproductive and respiratory syndrome virus comparison: Divergent evolution on two continents
28. Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14
29. Experimental inoculation of late-term pregnant sows with a field isolate of PRRS vaccine-like virus
30. Analysis of ORF1 in European porcine reproductive and respiratory syndrome virus by long RT-PCR and restriction fragment length polymorphism (RFLP) analysis
31. Sensitive detection and typing of porcine reproductive and respiratory syndrome virus by RT-PCR amplification of whole viral genes
32. Determination of 5′-leader sequences from radically disparate strains of porcine reproductive and respiratory syndrome virus reveals the presence of highly conserved sequence motifs
33. Emergence of porcine reproductive and respiratory syndrome virus deletion mutants: Correlation with the porcine antibody response to a hypervariable site in the ORF 3 structural glycoprotein
34. PHD: Predicting one-dimensional protein structure by profile-based neural networks
35. The molecular biology of arteriviruses
36. Examination of the selective pressures on a live PRRS vaccine virus
37. Yellow fever 17D vaccine virus isolated from healthy vaccinees accumulates very few mutations
38. Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites
39. PAML: A program package for phylogenetic analysis by maximum likelihood
40. Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
41. Synonymous and nonsynonymous rate variation in nuclear genes of mammals
42. Recombination between North American strains of porcine reproductive and respiratory syndrome virus