Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype

Archives of Virology

Volumn 145, Issue 6, 2000, Pages 1149-1161

  Allende, R ^a   Kutish, G F ^b   Laegreid, W ^c   Lu, Z ^b   Lewis, T L ^b   Rock, D L ^b   Friesen, J ^a   Galeota, J A ^a   Doster, A R ^a   Osorio, F A ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

^c U S MEAT ANIMAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; GENETIC STRAIN; LIVE VACCINE; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHENOTYPE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; SEQUENCE HOMOLOGY; VIRUS GENOME; VIRUS MUTATION;

ANIMALS; FEMALE; GENOME, VIRAL; MOLECULAR SEQUENCE DATA; MUTATION; OPEN READING FRAMES; PHENOTYPE; POLYMERASE CHAIN REACTION; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SWINE; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRAL VACCINES; VIRULENCE;

ANIMALIA; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; SUIDAE;

EID: 0033923075     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050070115     Document Type: Article

References (33)

1. 1. Albina E (1997) Porcine reproductive and respiratory syndrome: ten years of experience (1986-1996) with this undesirable virus infection. Vet Res 28: 305-352
2. 2. Allende R, Lewis TL, Lu Z, Rock DL, Kutish GF, All A, Doster AR, Osorio FA (1999) North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J Gen Virol 80: 307-315
3. 3. Cavanagh D (1997) Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol 142: 629-633
4. th
5. 5. Christensen C, Warren W, Zhang A (1998) Efficacy and safety studies with a killed PRRS. Proceedings of the American Association of Swine Practitioners, pp 99-101
6. 6. Christianson WT, Collins JW, Benfield DA, Harris L, Gorcyca DE, Chladek DW, Morrison RB, Joo HS (1992) Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows. Am J Vet Res 53: 485-488
7. 7. Den Boon JA, Faaberg KS, Meulenberg JJM, Wassenaar ALM, Plagemann PGW, Gorbalenya AE, Snijder EJ (1995) Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a proteins: identification of two papainlike cysteine proteases. J Virol 69: 4500-4505
8. 8. de Vries AAF, Horzinek MC, Rottier PJM, de Groot RJ (1997) The genome organization of the nidovirales: similarities and differences between arteri-, toro- and coronaviruses. Semin Virol 8: 33-47
9. 9. Dietzschold B, Wunner WH, Wiktor TJ, Lopes AD, Lafon M, Smith CL, Koprowski H (1983) Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus. Pro Natl Acad Sci USA 80: 70-74
10. 10. Gorcyca DE, Schlesinger KJ, Chladek DW, Behan W (1995) RespPRRS: a new tool for the prevention and control of PRRS in pigs. Proceedings of the American Association of Swine Practitioners 26th annual meeting, Omaha, Nebraska, USA, 4-7 March, and pp 1-22
11. 11. Kapur V, Elam MR, Pawolovich TM, Murtaugh MP (1996) Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States. J Gen Virol 77: 1271-1276
12. 12. Kim HS, Kwang J, Yoon IJ, Joo HS, Frey ML (1993) Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line. Arch Virol 133: 477-483
13. 13. Leparc-Goffart I, Hingley ST, Jiang X, Chua MM, Lavi E, Weiss SR (1998) The C12 mutant of MHV-A59 is very weakly demyelinating and has five amino acid substitutions restricted to the spike and replicase genes. Adv Exp Med Biol 440: 627-633
14. 14. Liao C-L, Lai MM (1994) Requirement of the 5′-end genomic sequence as an upstream cis-acting element for coronavirus subgenomic mRNA transcription. J Virol 68: 4727-4737
15. 15. Madsen KG, Hansen CM, Madsen ES, Strandbygaard B, Botner A, Sorensen KJ (1998) Sequence analysis of porcine reproductive and respiratory syndrome virus of the American type collected from Danish swine herds. Arch Virol 143: 1683-1700
16. 16. Meng K-J, Paul PS, Halbur PG, Morozov I (1995) Sequence comparison of open frames 2 to 5 of low and high virulence United States isolates of porcine reproductive and respiratory syndrome virus. J Gen Virol 76: 3181-3188
17. 17. Mengeling WL, Vorwald AC, Lager KM, Clouser DF, Wesley RD (1999) Identification and clinical assessment of suspected vaccine related field strains of porcine reproductive and respiratory syndrome virus. Am J Vet Res 60: 334-340
18. 18. Meulenberg JJM, Hulst MM, de Meijer EJ, Moonen PLJM, den Besten A, de Kluyver EP, Wensvoort G, Moormann RJM (1993) Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 192:62-72
19. 19. Nelsen CJ, Murtaugh MP, Faaberg KS (1999) Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J Virol 73: 270-280
20. 20. Osorio FA, Zuckermann F, Wills R, Meier W, Christian S, Galeota J, Doster A (1998) PRRSV: comparison of commercial vaccines in their ability to induce protection against current PRRSV strains of high virulence. Allen D. Leman Swine Conference 25: 176-182
21. 21. Pirzadeh B, Dea S (1998) Immune response in pigs vaccinated with plasmid DNA encoding ORF5 of porcine reproductive and respiratory syndrome virus. J Gen Virol 79: 989-99
22. 22. Plana Duran J, Bastons M, Urniza A, Vayreda M, Vila X, Mane H (1997) Efficacy of an inactivated vaccine for prevention of reproductive failure induced by porcine reproductive and respiratory syndrome virus. Vet Microbiol 55: 361-370
23. 23. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467
24. 24. Snijder EJ, Meulenberg JJM (1998) The molecular biology of arteriviruses. J Gen Virol 79: 961-979
25. 25. Snijder EJ, van Tol H, Pedersen KW, Raamsman MJB, de Vries AAF (1999) Identification of a novel structural protein of arteriviruses. J Virol 73: 6335-6345
26. 26. Srinivasappa J, Clark JT, Gill M, Acree B, Chu H-J (1999) Safety of Fort Dodge laboratories porcine reproductive and respiratory syndrome virus vaccine in pigs. Proceedings of the American Association of Swine Practitioners, pp 141-145
27. 27. Sur J-H, Cooper VL, Galeota JA, Hesse RA, Doster AR, Osorio FA (1996) In vivo detection of porcine reproductive and respiratory syndrome virus RNA by in situ hybridization at different times postinfection. J Clin Microbiol 34: 2280-2286
28. 28. van Dinten LC, Rensen S, Gorbalenya AE, Snijder EJ (1999) Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and is essential for virus replication. J Virol 73: 2027-2037
29. 29. Wassenaar ALM, Spaan WJM, Gorbalenya AE, Snijder EJ (1997) Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease. J Virol 71: 9313-9322
30. 30. Wensvoort G, Terpstra C, Pol J (1991) Blue ear disease of pigs. Vet Rec 128: 574
31. 31. Wesley RD, Mengeling WL, Lager KM, Vorwald AC, Roof MB (1999) Evidence for divergence of restriction fragment length polymorphism patterns following in vivo replication of porcine reproductive and respiratory syndrome virus. Am J Vet Res 60: 463-467
32. 32. Westrop GD, Wareham KA, Evans DMA, Dunn G, Minor PD, Magrat DI, Tafes F, Marsden S, Skinner MA, Schild GC, Almond JW (1989) Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine. J Virol 63: 1338-1344
33. 33. Yang SX, Kwang J, Laegreid W (1998) Comparative sequence analysis of open reading frames 2 to 7 of the modified live vaccine virus and other North American isolates of the porcine reproductive and respiratory syndrome virus. Arch Virol 143: 1-12