Multiple signaling pathways mediate interleukin-4-induced 3β-hydroxysteroid dehydrogenase/δ5-δ4 isomerase type 1 gene expression in human breast cancer cells

Molecular Endocrinology

Volumn 14, Issue 2, 2000, Pages 229-240

  Gingras, Sebastien ^a   Côté, Stéphanie ^a   Simard, Jacques ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; INSULIN; INTERLEUKIN 13; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; SOMATOMEDIN C; STEROID DELTA ISOMERASE; WORTMANNIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HORMONE ACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; BREAST NEOPLASMS; CHROMONES; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-4; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MORPHOLINES; MULTIENZYME COMPLEXES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROGESTERONE REDUCTASE; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; STEROID ISOMERASES; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0034456023     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.14.2.229     Document Type: Article

References (69)

1. 4 isomerase gene family
2. 4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13
3. Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells
4. Interleukin-4: A prototypic immunoregulatory lymphokine
5. Inhibition of colon and breast carcinoma cell growth by interleukin-4
6. Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells
7. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
8. An interleukin-4-induced transcription factor: IL-4 Stat
9. Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-γ-induced nuclear binding factor
10. Signaling by the cytokine receptor superfamily: JAKs and STATs
11. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
12. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
13. STAT6: Its role in interleukin-4-mediated biological functions
14. Insulin signal transduction and the IRS proteins
15. Common elements in interleu-kin-4 and insulin signaling pathways in factor-dependent hematopoietic cells
16. Role of IRS-2 in insulin and cytokine signalling
17. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth
18. IRS-1: Essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells
19. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
20. Role of IRS-1-GRB-2 complexes in insulin signaling
21. Phosphoinositide kinases
22. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
23. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
24. Activation of protein kinase C family members by the novel polyphosphoinositides Ptdlns-3,4-P2 and and Ptdlns-3,4,5-P3
25. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
26. Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase
27. Effects of phorbol esters on insulin-induced activation of phosphatidylinositol 3-kinase, glucose transport, and glycogen synthase in rat adipocytes
28. Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin
29. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
30. HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor
31. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway
32. Evidence for a role of phosphatidylinositol 3-kinase in IL-4-induced germline C ∈ transcription
33. A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids
34. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase
35. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
36. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling
37. Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin
38. Involvement of ras p21 protein in signal-transduction pathways from interleukin-2, interleukin-3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin-4
39. Interleukin-4 induces activation of mitogen-activated protein kinase and phosphorylation of shc in human keratinocytes
40. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
41. Protein kinase C and its substrates
42. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells
43. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
44. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
45. Disruption of IRS-2 causes type 2 diabetes in mice
46. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
47. Immunohistochemical study of TGF-α, TGF-β1, EGFR, and IGF-1 expression in human breast carcinoma
48. The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site
49. In vitro IgE production by interleukin-4-stimulated human peripheral blood mononuclear cells is suppressed by rapamycin
50. Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin
51. Interleukin-4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin
52. Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins
53. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
54. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
55. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes
56. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser(725) of Stat5a and Ser(730) of Stat5b in prolactin-sensitive cells
57. Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
58. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
59. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase
60. Lactogenic hormone activation of Stat5 and transcription of the β-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activity
61. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells
62. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells
63. Phosphatidylinositol-3-OH kinase as a direct target of Ras
64. Association of p21 ras with phosphatidylinositol 3-kinase
65. Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes
66. Differential activation of mitogen-activated protein kinase by insulin and epidermal growth factor in 3T3-L1 adipocytes: A possible involvement of PI3-kinase in the activation of the MAP kinase by insulin
67. Identification of a novel · pathway important for proliferation and differentiation of primary erythroid progenitors
68. Induction of 3β-hydroxysteroid dehydrogenase/isomerase type 1 expression by interleukin-4 in human normal prostate epithelial cells, immortalized keratinocytes, colon, and cervix cancer cell lines
69. β-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor