-
1
-
-
0032749496
-
Presenilin 1 protein directly interacts with Bcl-2
-
(1999)
J Biol Chem
, vol.274
, pp. 30764-30769
-
-
Alberici, A.1
Moratto, D.2
Benussi, L.3
Gasparini, L.4
Ghidoni, R.5
Gatta, L.B.6
Finazzi, D.7
Frisoni, G.B.8
Trabucchi, M.9
Growdon, J.H.10
Nitsch, R.M.11
Binetti, G.12
-
2
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Price, D.L.8
Sisodia, S.S.9
-
3
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
(1997)
Nature Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George Hyslop, P.22
Selkoe, D.J.23
more..
-
5
-
-
0030769092
-
Alzheimer's Aβ(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
-
(1997)
Nature Med
, vol.3
, pp. 1021-1023
-
-
Cook, D.G.1
Forman, M.S.2
Sung, J.C.3
Leight, S.4
Kolson, D.L.5
Iwatsubo, T.6
Lee, V.M.7
Doms, R.W.8
-
6
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
7
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Satig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
8
-
-
15444341611
-
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins
-
(1997)
J Biol Chem
, vol.272
, pp. 3590-3598
-
-
De Strooper, B.1
Beullens, M.2
Contreras, B.3
Levesque, L.4
Craessaerts, K.5
Cordell, B.6
Moechars, D.7
Bollen, M.8
Fraser, P.9
George-Hyslop, P.S.10
Van Leuven, F.11
-
9
-
-
16044366039
-
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
10
-
-
0021803192
-
Demence presenile d'Alzheimer transmise dans une famille etendue
-
(1985)
Rev Neurol (Paris)
, vol.141
, pp. 194-202
-
-
Foncin, J.F.1
Salmon, D.2
Supino-viterbo, V.3
Feldman, R.G.4
Macchi, G.5
Mariotti, P.6
Scoppetta, C.7
Caruso, G.8
Bruni, A.C.9
-
11
-
-
0030944258
-
Clinicopathological features of familial Alzheimer's disease with the M139V mutation in the presenilin 1 gene
-
(1997)
Brain
, vol.120
, pp. 491-501
-
-
Fox, N.C.1
Kennedy, A.M.2
Harvey, R.J.3
Lantos, P.L.4
Roques, P.K.5
Collinge, J.6
Hardy, J.7
Hutton, M.8
Stevens, J.M.9
Warrington, E.K.10
Rossor, M.N.11
-
13
-
-
0026088977
-
Segregation of a missene mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Talbot, C.15
Pericak-Vance, M.16
Roses, A.17
Williamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
14
-
-
15144345926
-
A novel presenilin-1 mutation: Increased β-amyloid and neurofibrillary changes
-
(1997)
Ann Neurol
, vol.41
, pp. 809-813
-
-
Gomez-Isla, T.1
Wasco, W.2
Pettingell, W.P.3
Gurubhagavatula, S.4
Schmidt, S.D.5
Jondro, P.D.6
McNamara, M.7
Rodes, L.A.8
DiBlasi, T.9
Growdon, W.B.10
Seubert, P.11
Schenk, D.12
Growdon, J.H.13
Hyman, B.T.14
Tanzi, R.E.15
-
16
-
-
0028179341
-
Chemical characterization of Aβ 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease
-
(1994)
J Biol Chem
, vol.269
, pp. 10987-10990
-
-
Gowing, E.1
Roher, A.E.2
Woods, A.S.3
Cotter, R.J.4
Chaney, M.5
Little, S.P.6
Ball, M.J.7
-
17
-
-
0028915895
-
Amyloid β protein (Aβ) in Alzheimer's disease brain
-
(1995)
J Biol Chem
, vol.270
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
Long, K.E.4
Otvos, L.5
Younkin, L.H.6
Suzuki, N.7
Younkin, S.G.8
-
18
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
-
(1997)
Nature Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
Tienari, P.J.4
Ida, N.5
Allsop, D.6
Roberts, G.W.7
Masters, C.L.8
Dotti, C.G.9
Unsicker, K.10
Beyreuther, K.11
-
21
-
-
9344237637
-
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease
-
(1996)
NeuroReport
, vol.7
, pp. 810-905
-
-
Hutton, M.1
Busfield, F.2
Goate, A.3
Crook, R.4
PerezTur, J.5
Clark, R.F.6
Prihar, G.7
Talbot, C.8
Phillips, H.9
Wright, K.10
Baker, M.11
Lendon, C.12
Duff, K.13
Martinez, A.14
Houlden, H.15
Nichols, A.16
Karran, E.17
Roberts, G.18
Roques, P.19
Rossor, M.20
Venter, J.C.21
Adams, M.D.22
Cline, R.T.23
Phillips, C.A.24
Fuldner, R.A.25
Hardy, J.26
Goate, A.27
more..
-
23
-
-
0033523762
-
Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
-
(1999)
J Cell Biol
, vol.147
, pp. 121-134
-
-
Imafuku, I.1
Masaki, T.2
Waragai, M.3
Takeuchi, S.4
Kawabata, M.5
Hirai, S.6
Ohno, S.7
Nee, L.E.8
Lippa, C.F.9
Kanazawa, I.10
Imagawa, M.11
Okazawa, H.12
-
25
-
-
0030615092
-
Aβ1-40 but not Aβ1-42 levels in cortex correlate with apolipoprotein E e4 allele dosage in sporadic Alzheimer's disease
-
(1997)
Brain Res
, vol.748
, pp. 250-252
-
-
Ishii, K.1
Tamaoka, A.2
Mizusawa, H.3
Shoji, S.I.4
Ootake, T.5
Fraser, P.E.6
Takahashi, H.7
Tsuji, S.8
Gearing, M.9
Miutani, T.10
Yamada, S.11
Kato, M.12
St. George-Hyslop, P.H.13
Mirra, S.S.14
Mori, H.15
-
27
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury, P.T.2
-
28
-
-
0029968528
-
Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families
-
(1996)
Neurosci Lett
, vol.208
, pp. 195-198
-
-
Kamino, K.1
Sato, S.2
Sakaki, Y.3
Yoshiiwa, A.4
Nishiwaki, Y.5
Takeda, M.6
Tanabe, H.7
Nishimura, T.8
Ii, K.9
St. George-Hyslop, P.H.10
Miki, T.11
Ogihara, T.12
-
29
-
-
0023105114
-
The precursor of Alzheimers disease amyloid A4 protein resembles a cell-surface receptor
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.-G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
30
-
-
0027477716
-
Familial Alzheimer's disease. A pedigree with a missense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-glycine)
-
(1993)
Brain
, vol.116
, pp. 309-324
-
-
Kennedy, A.M.1
Newman, S.2
McCaddon, A.3
Ball, J.4
Roques, P.5
Mullan, M.6
Hardy, J.7
Chartier-Harlin, M.C.8
Frackowiak, R.S.J.9
Warrington, E.K.10
Rossor, M.N.11
-
31
-
-
0028278593
-
Amyloid precursor protein mutation causes Alzheimer's disease in Swedish family
-
(1993)
Neurosci Lett
, vol.168
, pp. 254-256
-
-
Lannfelt, L.1
Bogdanovic, N.2
Appelgren, H.3
Axelman, K.4
Lilius, L.5
Hansson, G.6
Schenk, D.7
Hardy, J.8
Winblad, B.9
-
33
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
(1996)
Nature Med
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
Lendon, C.L.4
Ossa, J.5
Saido, T.C.6
Yamaguchi, H.7
Ruiz, A.8
Martinez, A.9
Madrigal, L.10
Hincapie, L.11
Arango, J.C.12
Anthony, D.C.13
Koo, E.H.14
Goate, A.M.15
Selkoe, D.J.16
Arango, J.C.17
-
34
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
(1995)
Science
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.5
Weber, J.L.6
Bird, T.D.7
Schellenberg, G.D.8
-
35
-
-
0026688633
-
Mutation of a putative sperm membrane protein in caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions
-
(1992)
J Cell Biol
, vol.119
, pp. 55-69
-
-
L'Hernault, S.W.L.1
Arduengo, P.M.2
-
36
-
-
9044239670
-
Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway
-
(1996)
Neurology
, vol.46
, pp. 406-412
-
-
Lippa, C.F.1
Saunders, A.M.2
Smith, T.W.3
Swearer, J.M.4
Drachman, D.A.5
Ghetti, B.6
Nee, L.7
Pulaski-Salo, D.8
Dickson, D.9
Robitaille, Y.10
Bergeron, C.11
Crain, B.12
Benson, M.D.13
Farlow, M.14
Hyman, B.T.15
George-Hyslop, S.P.16
Roses, A.D.17
Pollen, D.A.18
-
37
-
-
0029869667
-
Predominant deposition of amyloid-β42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene
-
(1996)
Am J Pathol
, vol.148
, pp. 1257-1266
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Ihara, Y.3
Cairns, N.J.4
Lantos, P.L.5
Bogdanovic, N.6
Lannfelt, L.7
Winblad, B.8
Maat-Schieman, M.L.9
Rossor, M.N.10
-
38
-
-
9444276544
-
Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Aβ 42(43)
-
(1996)
Ann Neurol
, vol.40
, pp. 149-156
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Cairns, N.J.3
Lantos, P.L.4
Nochlin, D.5
Sumi, S.M.6
Bird, T.D.7
Poorkaj, P.8
Hardy, J.9
Hutton, M.10
Prihar, G.11
Crook, R.12
Rossor, M.N.13
Haltia, M.14
-
40
-
-
0029416825
-
High levels of amyloid-beta protein from S182 (Glu246) familial Alzheimer's cells
-
(1995)
Neuroreport
, vol.7
, pp. 217-220
-
-
Martins, R.N.1
Turner, B.A.2
Carroll, R.T.3
Weeney, D.4
Kim, K.S.5
Wisniewski, H.M.6
Blass, J.P.7
Gibson, G.E.8
Gandy, S.9
-
42
-
-
0027219223
-
Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 val-ile mutation in amyloid precursor protein gene
-
(1993)
Neurobiol Aging
, vol.14
, pp. 407-419
-
-
Mullan, M.1
Tsuji, S.2
Miki, T.3
Katsuya, T.4
Naruse, S.5
Kaneko, K.6
Shimizu, T.7
Kojima, T.8
Nakano, I.9
Ogihara, T.10
Miyatake, T.11
Ovenstone, I.12
Crawford, F.13
Goate, A.14
Hardy, J.15
Roques, P.16
Roberts, G.17
Luthert, P.18
Lantos, P.19
Clark, C.20
Gaskell, P.21
Crain, B.22
Roses, A.23
more..
-
43
-
-
0027024651
-
A locus for familial early-onset Alzheimer's disease on the long-arm of chromosome 14 proximal to the alpha 1 antichymotrypsin gene
-
(1992)
Nature Genet
, vol.2
, pp. 340-343
-
-
Mullan, M.1
Houlden, H.2
Windelspecht, M.3
Fidani, L.4
Lombardi, C.5
Diaz, P.6
Rossor, M.7
Crook, R.8
Hardy, J.9
Duff, K.10
Crawford, F.11
-
45
-
-
0029554875
-
A mutation in the Alzheimer's disease destroying a splice acceptor site in the presenilin 1 gene
-
(1995)
NeuroReport
, vol.7
, pp. 297-301
-
-
Perez-Tur, J.1
Froelich, S.2
Hutton, M.3
Crook, R.4
Baker, M.5
Duff, K.6
Wragg, M.7
Busfield, F.8
Lendon, C.9
Clark, R.F.10
Roques, P.11
Fuldner, R.A.12
Johnston, J.13
Cowburn, R.14
Forsell, C.15
Axelman, K.16
Lilius, L.17
Houlden, H.18
Karran, E.19
Roberts, G.W.20
Rossor, M.21
Adams, M.D.22
Hardy, J.23
Goate, A.24
Lannfelt, L.25
Hutton, M.26
more..
-
48
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
Mar, L.11
Sorbi, S.12
Nacmias, B.13
Piacentini, S.14
Amaducci, L.15
Chumakov, I.16
Cohen, D.17
Lannfelt, L.18
Fraser, P.E.19
Rommens, J.M.20
St. George Hyslop, P.H.21
more..
-
50
-
-
0027430805
-
Chromosome 14 and late onset familial Alzheimer's disease
-
(1993)
Am J Hum Genet
, vol.35
, pp. 619-628
-
-
Schellenberg, G.D.1
Peyami, H.2
Wijsman, E.M.3
Orr, H.T.4
Goddard, K.A.B.5
Anderson, L.6
Memens, E.7
White, J.A.8
Alonso, M.E.9
Ball, M.J.10
Kaye, J.11
Morris, J.C.12
Chui, H.13
Sasovnick, A.D.14
Heston, L.L.15
Martin, G.M.16
Bird, T.D.17
-
51
-
-
0026471656
-
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Orr, H.T.4
Anderson, L.5
Nemens, E.6
White, J.A.7
Bonnycastle, L.8
Weber, J.L.9
Alonso, M.E.10
Potter, H.11
Heston, L.L.12
Martin, G.M.13
-
52
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
(1996)
Nature Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
53
-
-
0033529331
-
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7932-7937
-
-
Schwarzman, A.L.1
Singh, N.2
Tsiper, M.3
Gregori, L.4
Dranovsky, A.5
Vitek, M.P.6
Glabe, C.G.7
St. George Hyslop, P.H.8
Goldgaber, D.9
-
54
-
-
0029784838
-
Amyloid β-protein and the genetics of Alzheimer's disease
-
(1996)
J Biol Chem
, vol.271
, pp. 18295-18298
-
-
Selkoe, D.J.1
-
56
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsrda, T.11
Mar, L.12
Foncin, J.F.13
Brini, A.C.14
Montese, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinsky, R.J.24
Wasco, W.25
Da Silva, H.A.R.26
Haines, J.L.27
Pericak-Vance, M.A.28
Tnazi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommens, J.M.32
St. George-Hyslop, P.H.33
more..
-
57
-
-
0027032695
-
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
-
(1992)
Nature Genet
, vol.2
, pp. 330-334
-
-
St. George-Hyslop, P.H.1
Haines, J.2
Rogaeva, E.3
Mortilla, M.4
Vaula, G.5
Pericak-Vance, M.6
Foncin, J.F.7
Montesi, M.8
Bruni, A.9
Sorbi, S.10
Rainero, I.11
Pinessi, L.12
Pollen, D.13
Polinsky, R.14
Nee, L.15
Kennedy, J.16
Macciardi, F.17
Rogaeva, E.18
Liang, Y.19
Alexandrova, N.20
Lukiw, W.21
Schlumpf, K.22
Tanzi, R.23
Tsuda, T.24
Farrer, L.25
Cantu, J.M.26
Duara, R.27
Amaducci, L.28
Bergamini, L.29
Gusella, J.30
Roses, A.31
McLachlan, C.32
more..
-
59
-
-
0028322017
-
An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.-D.3
Odaka, A.4
Otvos, L.5
Eckman, C.6
Golde, T.E.7
Younkin, S.G.8
-
64
-
-
8044231311
-
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
-
(1996)
Molec Med
, vol.2
, pp. 673-691
-
-
Walter, J.1
Capell, A.2
Grunberg, J.3
Pesold, B.4
Schindzielorz, A.5
Prior, R.6
Podlisny, M.B.7
Fraser, P.8
Hyslop, P.S.9
Selkoe, D.J.10
Haass, C.11
-
71
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and beta APP processing
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.S.9
Kawaral, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Millman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.N.24
Aebersold, R.25
Farrer, L.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St. George-Hyslop, P.30
more..
-
72
-
-
0028945660
-
Evidence that Aβ42 is the real culprit in Alzheimer's disease
-
(1995)
Ann Neurol
, vol.37
, pp. 287-288
-
-
Younkin, S.G.1
|