메뉴 건너뛰기




Volumn 133, Issue 2, 1998, Pages 161-167

The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation

Author keywords

DNA double strand break repair; DNA dependent protein kinase; Quiescent cells; Radiosensitization; Wortmannin

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; RADIOSENSITIZING AGENT; WORTMANNIN;

EID: 0032414839     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00221-3     Document Type: Article
Times cited : (23)

References (35)
  • 1
    • 0028823417 scopus 로고
    • Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity
    • Allalunis-Turner M.J., Lintott L.G., Barron G.M., Day R.S. III, Lees-Miller S.P. Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity. Cancer Res. 55:1995;5200-5202.
    • (1995) Cancer Res. , vol.55 , pp. 5200-5202
    • Allalunis-Turner, M.J.1    Lintott, L.G.2    Barron, G.M.3    Day R.S. III4    Lees-Miller, S.P.5
  • 4
    • 0027468265 scopus 로고
    • A binding of Ku protein to DNA: Measurement of affinity for ends and demonstration of binding to nicks
    • Blier P.R., Griffith A.J., Graft J., Hardin J.A. A binding of Ku protein to DNA: measurement of affinity for ends and demonstration of binding to nicks. J. Biol. Chem. 268:1993;7594-7601.
    • (1993) J. Biol. Chem. , vol.268 , pp. 7594-7601
    • Blier, P.R.1    Griffith, A.J.2    Graft, J.3    Hardin, J.A.4
  • 6
    • 0020663062 scopus 로고
    • A severe combined immuno-deficiency mutation in the mice
    • Bosma G.C., Custer R.P., Bosma M.J. A severe combined immuno-deficiency mutation in the mice. Nature. 301:1983;527-530.
    • (1983) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 7
    • 0029803485 scopus 로고    scopus 로고
    • Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells
    • Boulton S., Kyle S., Yalcintepe L., Durkacz B. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis. 17:1996;2285-2290.
    • (1996) Carcinogenesis , vol.17 , pp. 2285-2290
    • Boulton, S.1    Kyle, S.2    Yalcintepe, L.3    Durkacz, B.4
  • 8
    • 0023815374 scopus 로고
    • The use of restriction endonucleases to study relationship between DNA double-strand breaks, chromosomal aberrations and other end-points in mammalian cells
    • Bryant P.E. The use of restriction endonucleases to study relationship between DNA double-strand breaks, chromosomal aberrations and other end-points in mammalian cells. Int. J. Radiat. Biol. 54:1988;869-890.
    • (1988) Int. J. Radiat. Biol. , vol.54 , pp. 869-890
    • Bryant, P.E.1
  • 9
    • 0026595636 scopus 로고
    • Inactivation of p53 gene in human and murine osteosarcoma cells
    • Chandar N., Billig B., McMaster J., Novak J. Inactivation of p53 gene in human and murine osteosarcoma cells. Br. J. Cancer. 65:1992;208-214.
    • (1992) Br. J. Cancer , vol.65 , pp. 208-214
    • Chandar, N.1    Billig, B.2    McMaster, J.3    Novak, J.4
  • 10
    • 0023442466 scopus 로고
    • Deficiency in DNA repair in mouse lymphoma strain L5178Y-S
    • Evans H.H., Ricanati M., Horng M.-F. Deficiency in DNA repair in mouse lymphoma strain L5178Y-S. Proc. Natl. Acad. Sci. USA. 84:1987;7562-7566.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7562-7566
    • Evans, H.H.1    Ricanati, M.2    Horng, M.-F.3
  • 11
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implication for site-specific recombination and DNA double-strand break repair
    • Finnie N.J., Gottlieb T.M., Blunt T., Jeggo P.A., Jackson S.P. DNA-dependent protein kinase activity is absent in xrs-6 cells: implication for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA. 92:1995;320-324.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 12
    • 0025011134 scopus 로고
    • The scid mutation in mice causes a general defect in DNA repair
    • Fulop G.M., Phillips R.A. The scid mutation in mice causes a general defect in DNA repair. Nature. 347:1990;479-482.
    • (1990) Nature , vol.347 , pp. 479-482
    • Fulop, G.M.1    Phillips, R.A.2
  • 15
    • 0025845230 scopus 로고
    • Comparison of DNA double strand break rejoining as measured by pulse field gel electrophoresis, neutral sucrose gradient centrifugation and non-unwinding filter elution in irradiated plateau phase CHO cells
    • Iliakis G., Blocher D., Metzger L., Pantelias G. Comparison of DNA double strand break rejoining as measured by pulse field gel electrophoresis, neutral sucrose gradient centrifugation and non-unwinding filter elution in irradiated plateau phase CHO cells. Int. J. Radiat. Biol. 56:1991;927-937.
    • (1991) Int. J. Radiat. Biol. , vol.56 , pp. 927-937
    • Iliakis, G.1    Blocher, D.2    Metzger, L.3    Pantelias, G.4
  • 17
    • 0021712508 scopus 로고
    • X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining
    • Kemp L.M., Sedgwick S.G., Jeggo P.A. X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining. Mutat. Res. 132:1984;189-196.
    • (1984) Mutat. Res. , vol.132 , pp. 189-196
    • Kemp, L.M.1    Sedgwick, S.G.2    Jeggo, P.A.3
  • 19
    • 0028946775 scopus 로고
    • Pulse field gel electrophoresis measurement of DNA double strand breaks caused by restriction endonucleases in X-ray sensitive CHO mutant cells (xrs-5)
    • Kinashi Y., Okayasu R., Iliakis G., Nagasawa H., Little J.B. Pulse field gel electrophoresis measurement of DNA double strand breaks caused by restriction endonucleases in X-ray sensitive CHO mutant cells (xrs-5). Radiat. Res. 141:1995;153-159.
    • (1995) Radiat. Res. , vol.141 , pp. 153-159
    • Kinashi, Y.1    Okayasu, R.2    Iliakis, G.3    Nagasawa, H.4    Little, J.B.5
  • 20
    • 0024238629 scopus 로고
    • Induction and rejoining of DNA double-strand breaks in human cervix carcinoma cell lines of differing radiosensitivity
    • Kelland L.R., Edwards S.M., Steel G.G. Induction and rejoining of DNA double-strand breaks in human cervix carcinoma cell lines of differing radiosensitivity. Radiat. Res. 116:1988;526-538.
    • (1988) Radiat. Res. , vol.116 , pp. 526-538
    • Kelland, L.R.1    Edwards, S.M.2    Steel, G.G.3
  • 22
    • 0028906827 scopus 로고
    • The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair
    • Komatsu K., Kubota N., Gallo M., Okumura Y., Lieber M.R. The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair. Cancer Res. 55:1995;1774-1779.
    • (1995) Cancer Res. , vol.55 , pp. 1774-1779
    • Komatsu, K.1    Kubota, N.2    Gallo, M.3    Okumura, Y.4    Lieber, M.R.5
  • 23
    • 0027313289 scopus 로고
    • Functional complementation in mouse-human radiation-hybrids assigns the putative murine SCID gene to the pericentric region of human chromosome 8
    • Komatsu K., Ohta T., Jinno Y., Nikawa N., Okumura Y. Functional complementation in mouse-human radiation-hybrids assigns the putative murine SCID gene to the pericentric region of human chromosome 8. Hum. Mol. Genet. 2:1993;1031-1034.
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 1031-1034
    • Komatsu, K.1    Ohta, T.2    Jinno, Y.3    Nikawa, N.4    Okumura, Y.5
  • 24
    • 0030800783 scopus 로고    scopus 로고
    • Induction of a particular deletion in mitochondrial DNA by X rays depends on the inherent radiosensitivity of the cells
    • Kubota N., Hayashi J.-I., Inada T., Iwamura Y. Induction of a particular deletion in mitochondrial DNA by X rays depends on the inherent radiosensitivity of the cells. Radiat. Res. 148:1997;395-398.
    • (1997) Radiat. Res. , vol.148 , pp. 395-398
    • Kubota, N.1    Hayashi, J.-I.2    Inada, T.3    Iwamura, Y.4
  • 25
    • 0024589652 scopus 로고
    • Fixation and repair of radiation-induced potentially mutagenic damage sensitive to hypertonic treatment in human diploid fibroblasts
    • Kubota N., Hill C.K., Elkind M.M. Fixation and repair of radiation-induced potentially mutagenic damage sensitive to hypertonic treatment in human diploid fibroblasts. Mutat. Res. 216:1989;137-143.
    • (1989) Mutat. Res. , vol.216 , pp. 137-143
    • Kubota, N.1    Hill, C.K.2    Elkind, M.M.3
  • 28
    • 0031925138 scopus 로고    scopus 로고
    • Wortmannin inhibits DNA double strand break repair in irradiated normal human cells
    • in press.
    • R. Okayasu, K. Suetomi, R.L. Ullrich, Wortmannin inhibits DNA double strand break repair in irradiated normal human cells, Radiat. Res. (1998), in press.
    • (1998) Radiat. Res.
    • Okayasu, R.1    Suetomi, K.2    Ullrich, R.L.3
  • 29
    • 0028902932 scopus 로고
    • Loss of the catalytic subunit of the DNA-dependent protein-kinase in DNA double-strand-break-repair mutant mammalian cells
    • Peterson S.R., Kurimasa A., Oshimura M., Dynan W.S., Bradbury E.M., Chen J.D. Loss of the catalytic subunit of the DNA-dependent protein-kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA. 92:1995;3171-3174.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, J.D.6
  • 31
    • 0030066023 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
    • Price B., Youmell M. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res. 56:1996;246-250.
    • (1996) Cancer Res. , vol.56 , pp. 246-250
    • Price, B.1    Youmell, M.2
  • 32
    • 84960962997 scopus 로고
    • Action of x-rays on mammalian cells
    • Puck T.T., Marcus P.I. Action of x-rays on mammalian cells. J. Exp. Med. 103:1956;653-666.
    • (1956) J. Exp. Med. , vol.103 , pp. 653-666
    • Puck, T.T.1    Marcus, P.I.2
  • 33
    • 0024419461 scopus 로고
    • Association among DNA/chromosome break rejoining rates, chromatin structure alterations and radiation sensitivity in human tumor cell lines
    • Schwartz J.L., Vaughan T.M. Association among DNA/chromosome break rejoining rates, chromatin structure alterations and radiation sensitivity in human tumor cell lines. Cancer Res. 49:1989;5054-5057.
    • (1989) Cancer Res. , vol.49 , pp. 5054-5057
    • Schwartz, J.L.1    Vaughan, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.