Telomerase activity modulation in the prevention of prostate cancer

Urology

Volumn 57, Issue 4, 2001, Pages 148-153

  Kim, Nam W ^a   Hruszkewycz, Andrew M ^b  

^a GERON CORPORATION   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEOPROTEIN; TELOMERASE;

CANCER CELL; CANCER INHIBITION; CANCER PREVENTION; CARCINOGENESIS; CELL IMMORTALIZATION; CHROMOSOME REPLICATION; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC STABILITY; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; TELOMERE;

CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; MALE; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; RNA; RNA, MESSENGER; TELOMERASE; TELOMERE; TIME FACTORS;

EID: 0034977874     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-4295(00)00962-6     Document Type: Conference Paper

References (50)

1. Telomerase, cell immortality, and cancer
2. Extenuation of lifespan by introduction of telomerase into normal human cells
3. A critical role for telomeres in suppressing and facilitating carcinogenesis
4. Telomerases
5. Telomerase and senescence: The history, the experiment, the future
6. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancer in mice
7. Mammalian telomere dynamics: Healing, fragmentation shortening and stabilization
8. Origin of concatemeric T7 DNA
9. Telomere shortening during aging of human fibroblasts
10. Telomere reduction in human colorectal carcinoma and with aging
11. A survey of telomerase activity in human cancer
12. Specific association of human telomerase activity with immortal cells and cancer
13. Modifications of a telomeric repeat amplification protocol (TRAP) results in increased reliability, linearity and sensitivity
14. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)
15. Clinical implications of telomerase in cancer
16. A combination of semiquantitative telomerase assay and in-cell telomerase activity measurement using exfoliated urothelial cells for the detection of urothelial neoplasia
17. Cytological detection of telomerase activity using an in situ telomeric repeat amplification protocol assay
18. Expression of the RNA component of human telomerase (hTR) in prostate cancer, prostatic intraepithelial neoplasia, and normal prostate tissue
19. Localization of telomerase hTERT protein and hTR in benign mucosa, dysplasia, and squamous cell carcinoma of the cervix
20. Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas
21. Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes
22. Telomerase activity: A prevalent marker of malignant human prostate tissue
23. Telomerase activity in primary prostate cancer
24. Detection of telomerase activity in human prostate: A diagnostic marker for prostatic cancer
25. Detection of telomerase activity in prostate cancer by needle biopsy
26. Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon, and sarcoma
27. Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia, and benign prostatic epithelium
28. Detection of telomerase activity in prostate needle-biopsy samples
29. Telomerase activity, telomere length, and DNA ploidy in prostatic intraepithelial neoplasia (PIN)
30. Focal intratumoral heterogeneity for telomerase activity in human prostate cancer
31. Telomerase activity in needle biopsies from prostate cancer and benign prostates
32. The use of telomerase activity in the detection of prostatic cancer cells after prostatic massage
33. Telomerase activity in normal and malignant hematopoietic cells
34. Telomerase activity in human intestine
35. Telomerase activity in malignant and non-malignant skin conditions
36. The proliferative function of basal cells in the normal and hyperplastic human prostate
37. Lobe-specific telomerase activity in the intact adult brown Norway rat prostate and its regional distribution within the prostatic ducts
38. Telomerase is activated in the prostate and seminal vesicles of the castrated rat
39. Stem cell features of benign and malignant prostate epithelial cells
40. Telomerase catalytic subunit homologs from fission yeast and human
41. The RNA component of human telomerase
42. Creation of human tumour cells with defined genetic elements
43. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
44. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
45. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
46. 5,6-trans-16-ene-vitamin D3: A new class of potent inhibitors of proliferation of prostate, breast and myeloid leukemic cells
47. Modulation of telomerase activity by zinc in human prostatic and renal cancer cells
48. Suppression of telomerase, reexpression of KAI1, and abrogation of tumorigenicity by nerve growth factor in prostate cancer cell lines
49. Effects of androgens on telomerase activity in normal and malignant prostate cells in vitro
50. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells