Role of the hypervariable region in streptococcal M proteins: Binding of a human complement inhibitor

Journal of Immunology

Volumn 161, Issue 9, 1998, Pages 4894-4901

  Johnsson, Eskil ^a   Berggård, Karin ^a   Kotarsky, Heike ^a   Hellwage, Jens ^b   Zipfel, Peter F ^b   Sjöbring, Ulf ^a   Lindahl, Gunnar ^a  

^a LUND UNIVERSITY   (Sweden)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; COMPLEMENT INHIBITOR; VIRULENCE FACTOR;

ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; COMPLEMENT INHIBITION; COMPLEMENT SYSTEM; HOST RESISTANCE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES;

ANTIGENIC VARIATION; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BINDING, COMPETITIVE; BLOOD PROTEINS; CARRIER PROTEINS; COMPLEMENT C3B; HUMANS; PHAGOCYTOSIS; PROTEIN BINDING; STREPTOCOCCUS PYOGENES; VIRULENCE;

EID: 0032211139     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Bisno, A. L. 1991. Group A streptococcal infections and acute rheumatic fever. N. Engl. J. Med. 325:783.
2. Stevens, D. L. 1992. Invasive group A streptococcus infections. Clin. Infect. Dis. 14:2.
3. Fischetti, V. A. 1989. Streptococcal M protein: molecular design and biological behavior. Clin. Microbiol. Rev. 2:285.
4. Kehoe, M. A. 1994. Cell-wall-associated proteins in Gram-positive bacteria. New Compr. Biochem. 27:217.
5. Lancefield, R. C. 1962. Current knowledge of type-specific M antigens of group A streptococci. J. Immunol. 89:307.
6. Whatmore, A. M., V. Kapur, D. J. Sullivan, J. M. Musser, and M. A. Kehoe. 1994. Non-congruent relationships between variation in emm gene sequences and the population genetic structure of group A streptococci. Mol. Microbiol. 14:619.
7. Beall, B., R. Facklam, T. Hoenes, and B. Schwartz. 1997. Survey of emm gene sequences and T-antigen types from systemic Streptococcus pyogenes infection isolates collected in San Francisco, California; Atlanta, Georgia; and Connecticut in 1994 and 1995. J. Clin. Microbiol. 35:1231.
8. Borst, P. 1991. Molecular genetics of antigenic variation. Immunol. Today 12: A29.
9. Deitsch, K. W., E. R. Moxon, and T. E. Wellems. 1997. Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections. Microbiol. Mol. Biol. Rev. 61:281.
10. Thern, A., L. Stenberg, B. Dahlbäck, and G. Lindahl. 1995. Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system. J. Immunol. 154: 375.
11. Johnsson, E., A. Thern, B. Dahlbäck, L. O. Hedén, M. Wikström, and G. Lindahl. 1996. A highly variable region in members of the streptococcal M protein family binds the human complement regulator C4BP. J. Immunol. 157:3021.
12. + lineage. J. Immunol. 160:860.
13. Horstmann, R. D., H. J. Sievertsen, J. Knobloch, and V. A. Fischetti. 1988. Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H. Proc. Natl. Acad. Sci. USA 85:1657.
14. Sharma, A. K., and M. K. Pangburn. 1997. Localization by site-directed mutagenesis of the site in human complement factor H that binds to Streptococcus pyogenes M protein. Infect. Immun. 65:484.
15. Blackmore, T. K., V. A. Fischetti, T. A. Sadlon, H. M. Ward, and D. L. Gordon. 1998. M protein of group A Streptococcus binds to the seventh short consensus repeat of human complement factor H. Infect. Immun. 66:1427.
16. Kotarsky, H., J. Hellwage, E. Johnsson, C. Skerka, H. G. Svensson, G. Lindahl, U. Sjöbring, and P. F. Zipfel. 1998. Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins. J. Immunol. 160:3349.
17. Fischetti, V. A., R. D. Horstmann, and V. Pancholi. 1995. Location of the complement factor H binding site on streptococcal M6 protein. Infect. Immun. 63:149.
18. Misasi, R., H. P. Huemer, W. Schwaeble, E. Solder, C. Larcher, and M. P. Dierich. 1989. Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement. Eur. J. Immunol. 19:1765.
19. Hellwage, J., S. Kühn, and P. F. Zipfel. 1997. The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity. Biochem. J. 326:321.
20. Miller, L., L. Gray, E. Beachey, and M. Kehoe. 1988. Antigenic variation among group A streptococcal M proteins: nucleotide sequence of the serotype 5 M protein gene and its relationship with genes encoding types 6 and 24 M proteins. J. Biol. Chem. 263:5668.
21. Perez-Casal, J., N. Okada, M. G. Caparon, and J. R. Scott. 1995. Role of the conserved C-repeat region of the M protein of Streptococcus pyogenes. Mol. Microbiol. 15:907.
22. Stenberg, L., P. W. O'Toole, J. Mestecky, and G. Lindahl. 1994. Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both immunoglobulin A and immunoglobulin G. J. Biol. Chem. 269:13458.
23. Husmann, L. K., J. R. Scott, G. Lindahl, and L. Stenberg. 1995. Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes. Infect. Immun. 63:345.
24. Caparon, M. G., and J. R. Scott. 1991. Genetic manipulation of pathogenic streptococci. Methods Enzymol. 204:556.
25. Perez-Casal, J., J. A. Price, E. Maguin, and J. R. Scott. 1993. An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes: use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes. Mol. Microbiol. 8:809.
26. Perez-Casal, J., M. G. Caparon, and J. R. Scott. 1991. Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. J. Bacteriol. 173:2617.
27. Kühn, S., C. Skerka, and P. F. Zipfel. 1995. Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H. J. Immunol. 155:5663.
28. Laurell, C. B. 1972. Electroimmuno assay. Scand. J. Clin. Lab. Invest. 124(Suppl.):21.
29. Whaley, K., and S. Ruddy. 1976. Modulation of the alternative complement pathways by β1H globulin. J. Exp. Med. 144:1147.
30. Pangburn, M. K., R. D. Schreiber, and H. J. Müller-Eberhard. 1977. Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein β1H for cleavage of C3b and C4b in solution. J. Exp. Med. 146:257.
31. Liszewski, M. K., T. C. Farries, D. M. Lublin, I. A. Rooney, and J. P. Atkinson. 1996. Control of the complement system. Adv. Immunol. 61:201.
32. Zipfel, P. F., and C. Skerka. 1994. Complement factor H and related proteins: an expanding family of complement-regulatory proteins? Immunol. Today 15:121.
33. Kühn, S., and P. F. Zipfel. 1996. Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H. Eur. J. Immunol. 26:2383.
34. Greiff, L., I. Erjefält, C. Svensson, P. Wollmer, U. Alkner, M. Andersson, and C. G. Persson. 1993. Plasma exudation and solute absorption across the airway mucosa. Clin. Physiol. 13:219.
35. Åkerström, B., G. Lindahl, L. Björck, and A. Lindqvist. 1992. Protein Arp and protein H from group A streptococci. Ig binding and dimerization are regulated by temperature. J. Immunol. 148:3238.
36. Cedervall, T., M. U. Johansson, and B. Åkerström. 1997. Coiled-coil structure of group A streptococcal M proteins. Different temperature stability of class A and C proteins by hydrophobic-nonhydrophobic amino acid substitutions at heptad positions a and d. Biochemistry 36:4987.
37. Manjula, B. N., A. S. Acharya, T. Fairwell, and V. A. Fischetti. 1986. Antigenic domains of the streptococcal Pep M5 protein: localization of epitopes crossreactive with type 6 M protein and identification of a hypervariable region of the M molecule. J. Exp. Med. 163:129.
38. Horstmann, R. D., H. J. Sievertsen, M. Leippe, and V. A. Fischetti. 1992. Role of fibrinogen in complement inhibition by streptococcal M protein. Infect. Immun. 60:5036.
39. Robinson, J. H., and M. A. Kehoe. 1992. Group A streptococcal M proteins: virulence factors and protective antigens. Immunol. Today 13:362.
40. Müller-Eberhard, H. J. 1988. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57:321.
41. Jones, K. F., and V. A. Fischetti. 1988. The importance of the location of antibody binding on the M6 protein for opsonization and phagocytosis of group A M6 streptococci. J. Exp. Med. 167:1114.
42. Ehlenberger, A. G., and V. Nussenzweig. 1977. The role of membrane receptors for C3b and C3d in phagocytosis. J. Exp. Med. 145:357.
43. Newman, S. L., and R. B. Johnston, Jr. 1979. Role of binding through C3b and IgG in polymorphonuclear neutrophil function: studies with trypsin-generated C3b. J. Immunol. 123:1839.
44. Frithz, E., L. O. Hedén, and G. Lindahl. 1989. Extensive sequence homology between IgA receptor and M proteins in Streptococcus pyogenes. Mol. Microbiol. 3:1111.
45. Dahlbäck, B. 1991. Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulant system. Thromb. Haemost. 66:49.
46. Seya, T., K. Nakamura, T. Masaki, C. Ichihara-Itoh, M. Matsumoto, and S. Nagasawa. 1995. Human factor H and C4b-binding protein serve as factor I-cofactors both encompassing inactivation of C3b and C4b. Mol. Immunol. 32: 355.
47. Ollert, M. W., K. David, R. Bredehorst, and C. W. Vogel. 1995. Classical complement pathway activation on nucleated cells: role of factor H in the control of deposited C3b. J. Immunol. 155:4955.
48. Mikata, S., S. Miyagawa, K. Iwata, S. Nagasawa, M. Hatanaka, M. Matsumoto, W. Kamiike, H. Matsuda, R. Shirakura, and T. Seya. 1998. Regulation of complement-mediated swine endothelial cell lysis by a surface-bound form of human C4b binding protein. Transplantation 65:363.
49. DiScipio, R. G. 1992. Ultrastructures and interactions of complement factors H and I. J. Immunol. 149:2592.
50. Gordon, D. L., R. M. Kaufman, T. K. Blackmore, J. Kwong, and D. M. Lublin. 1995. Identification of complement regulatory domains in human factor H. J. Immunol. 155:348.
51. Blum, M. L., J. A. Down, A. M. Gurnett, M. Carrington, M. J. Turner, and D. C. Wiley. 1993. A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature 362:603.
52. Ahearn, J. M., and D. T. Fearon. 1989. Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv. Immunol. 46:183.
53. Naniche, D., G. Varior Krishnan, F. Cervoni, T. F. Wild, B. Rossi, C. Rabourdin Combe, and D. Gerlier. 1993. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67:6025.
54. Dörig, R. E., A. Marcil, A. Chopra, and C. D. Richardson. 1993. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75: 295.
55. Bergelson, J. M., M. Chan, K. R. Solomon, N. F. St. John, H. Lin, and R. W. Finberg. 1994. Decay-accelerating factor (CD55), a glycosylphosphatidyl-inositol-anchored complement regulatory protein, is a receptor for several echo-viruses. Proc. Natl. Acad. Sci. USA 91:6245.
56. Ward, T., P. A. Pipkin, N. A. Clarkson, D. M. Stone, P. D. Minor, and J. W. Almond. 1994. Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method. EMBO J. 13:5070.
57. Källström, H., M. K. Liszewski, J. P. Atkinson, and A. B. Jonsson. 1997. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol. Microbiol. 25:639.
58. Okada, N., M. K. Liszewski, J. P. Alkinson, and M. Caparon. 1995. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc. Natl. Acad. Sci. USA 92:2489.
59. Nowicki, B., A. Hart, K. E. Coyne, D. M. Lublin, and S. Nowicki. 1993. Short consensus repeat-3 domain of recombinant decay-accelerating factor is recognized by Escherichia coli recombinant Dr adhesin in a model of a cell-cell interaction. J. Exp. Med. 178:2115.
60. Rowe, J. A., J. M. Moulds, C. I. Newbold, and L. H. Miller. 1997. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature 388:292.
61. Berggård, K., E. Johnsson, F. R. Mooi, and G. Lindahl. 1997. Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin. Infect. Immun. 65:3638.
62. Ram, S., A. K. Sharma, S. D. Simpson, S. Gulati, D. P. McQuillen, M. K. Pangburn, and P. A. Rice. 1998. A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae. J. Exp. Med. 187:743.