The Saccharomyces cerevisiae small GTPase, gsp1p/Ran, is involved in 3′ processing of 7S-to-5.8S rRNA and in degradation of the excised 5′-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome

Genetics

Volumn 158, Issue 2, 2001, Pages 613-625

  Suzuki, Nobuhiro ^a,b   Noguchi, Eishi ^a   Nakashima, Nobutaka ^a   Oki, Masaya ^a   Ohba, Tomoyuki ^a   Tartakoff, Alan ^c   Ohishi, Masamichi ^b   Nishimoto, Takeharu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RAN PROTEIN; RIBOSOME RNA;

ALLELISM; ARTICLE; CELL TRANSPORT; ENZYME REGULATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; RNA DEGRADATION; RNA PROCESSING; SACCHAROMYCES CEREVISIAE;

ACTIVE TRANSPORT, CELL NUCLEUS; ALLELES; CELL NUCLEUS; CYTOPLASM; DEAD-BOX RNA HELICASES; DNA PRIMERS; FUNGAL PROTEINS; GENOTYPE; GTP PHOSPHOHYDROLASES; MODELS, GENETIC; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PLASMIDS; POLYMERASE CHAIN REACTION; RNA HELICASES; RNA SPLICING; RNA, MESSENGER; RNA, RIBOSOMAL; RNA, RIBOSOMAL, 5.8S; RNA, SMALL CYTOPLASMIC; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL RECOGNITION PARTICLE; TEMPERATURE; TIME FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 0034975301     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation
2. The yeast exosome and human PM-Sc1 are related complexes of 3′ → 5′ exonucleases
3. Degradation of ribosomal RNA precursors by the exosome
4. The role of Ran in nuclear function
5. On the fidelity of DNA replication: Manganese mutagenesis in vitro
6. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport
7. A positive selection for mutants lacking ortidine-5′-phosphate decarboxylase activity in yeast
8. Splicing of precursors to mRNAs by the spliceosomes
9. Diverse effects of the guanine nucleotide exchange factor RCC1 on Rna transport
10. Yeast pheromone response pathway: Characterization of a suppressor that restores mating to receptorless mutants
11. Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3′ end formation of 5.8S rRNA in Saccharomyces cerevisiae
12. Transport between the cell nucleus and the cytoplasm
13. Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX2 activity
14. DMSO-enhanced whole cell yeast transformation
15. The 5′ end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site
16. A yeast mutant which accumulates precursor tRNAs
17. Temperature-sensitive yeast mutant defective in ribonucleic acid production
18. The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex
19. A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase
20. Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily
21. Beyond nuclear transport: Ran-GTP as a determinant of spindle assembly
22. Trans-acting factors in yeast pre-rRNA and pre-snoRNA processing
23. A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction
24. A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA
25. Nucleocytoplasmic transport: The soluble phase
26. The small nucleolar RNAs
27. Two-way trafficking with Ran
28. The 3′ end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism
29. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′ → 5′ exoribonucleases
30. Importin β is a mitotic target of the small GTPase Ran in spindle assembly
31. A novel centrosomal protein, RanBPM, when overexpressed, causes ectopic microtubule nucleation, similar to γ-tubulin
32. Transport of proteins and RNAs in and out of the nucleus
33. A new role of Ran GTPase
34. Upstream and downstream of Ran GTPase
35. Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity, of RCC1
36. Yrb2p, Nup2p-related yeast protein has functional overlap with Rna1p, yeast RanGAP protein
37. Disruption of YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XP01/CRM1
38. A protein required for nuclear import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae Ran homologue
39. Nuclear protein import, but not mRNA export, is defective in all of the temperature-sensitive mutants of the Saccharomyces cerevisiae Ran homologue, Gsp1-GTPase
40. Disruption of U8 nucleolar snRNA inhibits 5.8S and 28S rRNA processing in the Xenopus oocyte
41. Translation initiation and ribosomal biogenesis: Involvement of a putative rRNA helicase and RPL46
42. RCC1 in the Ran pathway
43. Human Dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3
44. Exportin 1 (Crm1p) is an essential nuclear export factor
45. Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly
46. The exosome: A proteasome for RNA
47. Yeast exosome mutants accumulate 3′-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
48. Processing of eukaryotic pre-rRNA: The role of the transcribed spacers
49. Nucleocytoplasmic transport and processing of small nuclear RNA precursors
50. The structure and biogenesis of yeast ribosomes
51. Karyopherins and kissing cousins
52. Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure
53. The growing world of small nuclear ribonucleoproteins