Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

Neuropharmacology

Volumn 36, Issue 3, 1997, Pages 401-403

  Batchelor, A M ^a   Knopfel T ^a   Gasparini, F ^b   Garthwaite, J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

cerebellum; EPSP; glutamate; metabotropic glutamate receptor; mGlu1 receptor; synaptic transmission

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; 4 CARBOXYPHENYLGLYCINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ALPHA METHYL 4 PHOSPHONOPHENYLGLYCINE; BICUCULLINE; ETHYL 7 (HYDROXYIMINO) CYCLOPROPA[B]CHROMEN 1A CARBOXYLATE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; UPF 523;

ANIMAL CELL; ARTICLE; BRAIN SLICE; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; BENZOATES; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC TRANSMISSION;

EID: 0342981588     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00014-2     Document Type: Article

References (13)

1. Annoura H., Fukunaga A., Uesugi M., Tatsuoka T., Horikawa Y. A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclo-propa[b]chromen-1a-carboxylates. Bioorg. Med. Chem. Lett. 6:1996;763-766.
2. Batchelor A.M., Madge D.J., Garthwaite J. Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices. Neuroscience. 63:1994;911-915.
3. Constantino G., Pellicciari R. Homology modeling of metabotropic glutamate receptors (mGluRs). Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists. J. Med. Chem. 39:1996;3998-4006.
4. Conquet F., Bashir Z.I., Davies C.H., Daniel H., Ferraguti F., Bordi F., Franz-Bacon K., Reggiani A., Matarese V., Condé F., Collingridge G.L., Crépel F. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature. 372:1994;237-243.
5. Hayashi Y., Sekiyama N., Nakanishi S., Jane D.E., Sunter D.C., Birse E.F., Udvarhelyi P.M., Watkins J.C. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J. Neurosci. 14:1994;3370-3377.
6. Nicoletti F., Bruno V., Copani A., Casabona G., Knöpfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. 19:1996;267-271.
7. Pellicciari R., Luneia R., Costantino G., Marinozzi M., Natalini B., Jakobsen P., Kanstrup A., Lombardi G., Moroni F., Thomsen C. 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J. Med. Chem. 38:1995;3717-3719.
8. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
9. Roberts P.J. Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs): phenylglycine derivatives and other selective antagonists, an update. Neuropharmacology. 34:1995;813-819.
10. Saugstad J.A., Kinzie J.M., Mulvihill E.R., Segerson T.P., Westbrook G.L. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol. Pharmacol. 45:1994;367-372.
11. Shigemoto R., Nomura S., Ohishi H., Sugihara H., Nakanishi S., Mizuno N. Immunohistochemical localisation of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett. 163:1993;53-57.
12. Thomsen C., Boel E., Suzdak P.D. Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. Eur. J. Pharmacol. Mol. Pharmacol. 267:1994;77-84.
13. Watkins J.C., Collingridge G.L. Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmacol. Sci. 15:1994;333-342.