Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors

Neuropharmacology

Volumn 38, Issue 6, 1999, Pages 805-815

  Vetter, P ^a   Garthwaite, J ^a   Batchelor, A M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Disinhibition; Golgi cell; Grease gap; mGluRs

Indexed keywords

2 (2 CARBOXY 3 PHENYLCYCLOPROPYL)GLYCINE; 2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; 4 CARBOXYPHENYLGLYCINE; ALPHA METHYL 4 PHOSPHONOPHENYLGLYCINE; GLYCINE RECEPTOR AGONIST; GLYCINE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DOSE RESPONSE; ELECTROPHYSIOLOGY; GRANULE CELL; IN VITRO STUDY; MOSSY FIBER; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DENSITY; SYNAPTIC TRANSMISSION; TECHNIQUE;

ANIMALS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; NERVE FIBERS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC TRANSMISSION;

EID: 0032925129     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00003-9     Document Type: Article

References (55)

1. 2+ signal transduction. J. Biol. Chem. 267:1992;13361-13368.
2. Albani-Torregrossa S., Pellicciari R., Moroni F., Pellegrini-Giampietro E. Metabotropic glutamate receptors coupled to phospholipase D. Moroni F., Nicoletti F., Pellegrini-Giampietro D.E. Metabotropic Glutamate Receptors and Brain Function. 1998;251-260 Portland Press, London.
3. Barbour B., Häusser M. Intersynaptic diffusion of neurotransmitter. Trends Neurosci. 20:1997;377-384.
4. Batchelor A.M., Knöpfel T., Gasparini F., Garthwaite J. Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices. Neuropharmacology. 36:1997;401-403.
5. Batchelor A.M., Garthwaite J. Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature. 385:1997;74-77.
6. Bedingfield J.S., Jane D.E., Kemp M.C., Toms N.J., Roberts P.J. Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur. J. Pharmacol. 309:1996;71-78.
7. Breakwell N.A., Huang L., Rowan M.J., Anwyl R. DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus. Eur. J. Pharmacol. 322:1997;173-178.
8. A receptors. J. Physiol. 497:1996;753-759.
9. Bushell T.J., Jane D.E., Tse H.-W., Watkins J.C., Garthwaite J., Collingridge G.L. Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br. J. Pharmacol. 117:1996;1457-1462.
10. Chavis P., Shinozaki H., Bockaert J., Fagni L. The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J. Neurosci. 14:1994;7067-7076.
11. Chavis P., Nooney J.M., Bockaert J., Fagni L., Feltz A., Bossu J.L. Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells. J. Neurosci. 15:1995;135-143.
12. Collins D.R., Davies S.N. Co-administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid and arachidonic acid potentiates synaptic transmission in rat hippocampal slices. Eur. J. Pharmacol. 240:1993;325-326.
13. Conn P.J., Pin J.-P. Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. Toxicol. 37:1997;205-237.
14. Crepel F., Daniel H., Hemart N., Jaillard D. Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro. Exp. Brain Res. 86:1991;402-406.
15. Desai M.A., McBain C.J., Kauer J.A., Conn P.J. Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells. Neurosci. Lett. 181:1994;78-82.
16. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci. 15:1995;3075-3083.
17. East S.J., Garthwaite J. Actions of a metabotropic glutamate receptor agonist in immature and adult rat cerebellum. Eur. J. Pharmacol. 219:1992;395-400.
18. Eccles J., Ito M., Szentagothai J., 1967. The Cerebellum as a Neuronal Machine, Springer-Verlag, Berlin.
19. Gabbiani F., Midtgaard J., Knopfel T. Synaptic integration in a model of cerebellar granule cells. J. Neurophysiol. 72:1994;999-1009.
20. Garthwaite J., Batchelor A.M. A biplanar slice preparation for studying cerebellar synaptic transmission. J. Neurosci. Methods. 64:1996;189-197.
21. Garthwaite J., Brodbelt A.R. Glutamate as the principal mossy fibre transmitter in rat cerebellum: pharmacological evidence. Eur. J. Neurosci. 2:1989a;177-180.
22. Garthwaite J., Brodbelt A.R. Synaptic activation of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the mossy fibre pathway in adult and immature rat cerebellar slices. Neuroscience. 29:1989b;401-412.
23. Grandes P., Mateos J.M., Rüegg D., Kuhn R., Knöpfel T. Differential cellular localization of three splice variants of the mGluR1 metabotropic glutamate receptor in rat cerebellum. NeuroReport. 5:1994;2249-2252.
24. Hartell N.A. Induction of cerebellar long-term depression requires activation of glutamate metabotropic receptors. NeuroReport. 5:1994;913-916.
25. Harvey J., Collingridge G.L. Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices. Br. J. Pharmacol. 109:1993;1085-1090.
26. Hayashi Y., Momiyama A., Takahashi T., Ohishi H., Ogawa Meguro R., Shigemoto R., Mizuno N., Nakanishi S. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366:1993;687-690.
27. Hayashi Y., Sekiyama N., Nakanishi S., Jane D.E., Sunter D.C., Birse E.F., Udvarhelyi P.M., Watkins J.C. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J. Neurosci. 14:1994;3370-3377.
28. Herrero I., Miras Portugal M.T., Sanchez Prieto J. Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature. 360:1992;163-166.
29. Ito I., Kohda A., Tanabe S., Hirose E., Hayashi M., Mitsunaga S., Sugiyama H. 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. NeuroReport. 3:1992;1013-1016.
30. Kaneda M., Farrant M., Cull-Candy S.G. Whole-cell and single-channel currents activated by GABA and glycine in granule cells of the rat cerebellum. J. Physiol. 485:1995;419-435.
31. Kingston A.E., Lodge D. Pharmacology of group I metabotropic glutamate receptors. Moroni F., Nicoletti F., Pellegrini-Giampietro D.E. Metabotropic Glutamate Receptors and Brain Function. 1998;261-269 Portland Press, London.
32. Kinzie J.M., Saugstad J.A., Westbrook G.L., Segerson T.P. Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain. Neuroscience. 69:1995;167-176.
33. Kullman D.M., Asztely F. Extrasynaptic glutamate spillover in the hippocampus: evidence and implications. Trends Neurosci. 21:1998;8-14.
34. Lisberger S.G., Fuchs A.F. Role of primate flocculus during rapid behavioral modification of vestibuloocular reflex II. Mossy fibre fring pattern during head rotation and eye movement. J. Neurophysiol. 41:1978;764-777.
35. Ohishi H., Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridisation study. J. Comp. Neurol. 335:1993a;252-266.
36. Ohishi H., Shigemoto R., Nakanishi S., Mizuno N. Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience. 53:1993b;1009-1018.
37. Ohishi H., Ogawa Meguro R., Shigemoto R., Kaneko T., Nakanishi S., Mizuno N. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 13:1994;55-66.
38. Ohishi H., Neki A., Mizuno N. Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody. Neurosci. Res. 30:1998;65-82.
39. Pekhletski R., Gerlai R., Overstreet L.S., Huang X., Agopyan N., Slater N.T., Abramow-Newerly W., Roder J.C., Hampson D.R. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic gluatamate receptor. J. Neurosci. 16:1996;6364-6373.
40. Pellicciari R., Marinozzi M., Natalini B., Costantino G., Luneia R., Giorgi G., Moroni F., Thomsen C. Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2′-carboxy-3′-phenylcyclopropyl)glycine. Focus on (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. J. Med. Chem. 39:1996;2259-2269.
41. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
42. Pisani A., Calabresi P., Centonze D., Bernardi G. Activation of group III metabotropic glutamate receptors depresses glutamatergic transmission at corticostriatal synapse. Neuropharmacology. 36:1997;845-851.
43. Poncer J., Shinozaki H., Miles R. Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus. J. Physiol. 485:1995;121-134.
44. - currents in Purkinje versus granule neurons in rat cerebellar slices. Neuron. 12:1994;117-126.
45. Rossi P., D'Angelo E., Taglietti V. Differential long-lasting potentiation of the NMDA and non-NMDA synaptic currents induced by metabotropic and NMDA receptor coactivation in cerebellar granule cells. Eur. J. Neurosci. 8:1996;1182-1189.
46. Salt T.E., Turner J.P. Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR antagonist MPPG. Neuropharmacology. 35:1996;239-241.
47. Scanziani M., Salin P.A., Vogt K.E., Malenka R.C., Nicoll R.A. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature. 385:1997;630-634.
48. Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J. Comp. Neurol. 322:1992;121-135.
49. Shigemoto R., Nomura S., Ohishi H., Sugihara H., Nakanishi S., Mizuno N. Immunohistochemical localisation of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett. 163:1993;53-57.
50. Tanabe Y., Nomura A., Masu M., Shigemoto R., Mizuno N., Nakanishi S. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J. Neurosci. 13:1993;1372-1378.
51. Thomsen C., Boel E., Suzdak P.D. Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. Eur. J. Pharmacol. Mol. Pharmacol. 267:1994;77-84.
52. Thomsen C., Bruno V., Nicoletti F., Marinozzi M., Pellicciari R. (2S, 1′S, 2′S, 3′R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors. Mol. Pharmacol. 50:1996;6-9.
53. Toms N.J., Jane D.E., Kemp M.C., Bedingfield J.S., Roberts P.J. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br. J. Pharmacol. 119:1996;851-854.
54. A receptor-mediated currents in granule cells of postnatal rat cerebellum. Eur. J. Neurosci. 9:1997;533-548.
55. Wilsch V.W., Pidoplichko V.I., Opitz T., Shinozaki H., Reymann K.G. Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons. Eur. J. Pharmacol. 262:1994;287-291.