Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer

British Journal of Cancer

Volumn 77, Issue 6, 1998, Pages 998-1002

  Tokunaga, T ^a   Oshika, Y ^a   Abe, Y ^a   Ozeki, Y ^b   Sadahiro, S ^a   Kijima, H ^a   Tsuchida, T ^a   Yamazaki, H ^a   Ueyama, Y ^a,c   Tamaoki, N ^a   Nakamura, M ^a,c  

^a TOKAI UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c KANAGAWA ACADEMY OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Colon cancer; Isoform pattern; Liver metastasis; Vascular endothelial growth factor

Indexed keywords

MESSENGER RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER STAGING; COLON CANCER; FEMALE; HUMAN; HUMAN TISSUE; ISOMER; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 6844237654     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.164     Document Type: Article

References (22)

1. Ando M, Maruyama M, Oto M, Takemura K, Endo M and Yuasa Y (1991) Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas. Jpn J Cancer Res 82: 245-249
2. Berkman RA, Merril MJ, Reinhold WC, Monacci WT, Saxena A, Clark WC, Robertson JT, Ali IU and Oldfield EH (1993) Expression of the vascular permeability factor/vascular endothelial growth gene in central nervous system neoplasms. J Clin Invest 91: 153-159
3. Berse B, Brown LE, Vav De Water L, Dvorak HF and Senger DR (1992) Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell 3: 211-220
4. Boocock AC, Charnock-Jones SD, Sharkey MA, Mclaren J, Baker JP, Wright AK, Twentyman RP and Smith KS (1995) Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 87: 506-516
5. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger D and Dvorak H (1993) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 53: 4727-4735
6. Brown LF, Berse B, Jackman RW, Tognazzi K, Guildi A, Dvorak H, Senger D, Connonlly J and Schnitt S (1995) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 26: 86-91
7. Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi BZ and Neufeld G (1995) VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem 270: 11322-11326
8. Dolecki GJ and Connolly DT (1991) Effects of a variety of cytokines and inducing agents on vascular permeability factor mRNA levels in U937 cells. Biochem Biophys Res Commun 180: 572-578
9. Dvorak HF, Brown LF, Detmar M and Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1038
10. Gengrinovitch S, Greenberg SM, Cohen T, Gitay-Goren H, Rockwell P, Maiones TE, Levi B and Neufeld G (1995) Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms. J Biol Chem 270: 15059-15065
11. Houck KA, Ferrara N, Winer J, Cachianes G, Li B and Leung DW (1991) The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814
12. Houck KA, Leung DW, Rowland AM, Winer J and Ferrara N (1992) Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031-26037
13. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J and Connoly DT (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312
14. Koura AN, Liu W, Kitadai Y, Singh RK, Radinsky R and Ellis ML (1996) Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density. Cancer Res 56: 3891-3894
15. Leung DW, Cachianes G, Kuang WJ, Goeddel DV and Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309
16. Park J, Keller G-A and Ferrara N (1993) The vascular endothelial growth factor (VEGF) isoforms: differential disposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VHGF. Mol Biol Cell 4: 1317-1326
17. Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T and Kerbel RS (1995) Mutant ras oncogenes upregulate VEGK/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 55: 4575-4580
18. Sambrook J, Fritsh EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. p. 7.
19. Senger DR, Galli SJ, Dvorak AM, Peruzzi CA, Harvey VS and Dvorak HF (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983-985
20. Suzuki K, Hayashi N, Miyamoto Y, Yamamoto M, Ohkawa K, Ito Y, Sasaki Y, Yamaguchi Y, Nakase H, Noda K, Enomoto N, Arai K, Yamada Y, Yoshihara H, Tujimura T, Kawano K, Yoshikawa K and kamada T (1996) Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res 56: 3004-3009
21. Takahashi Y, Kitadai Y, Bucana CD, Cleary RK and Ellis LM (1995) Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55: 3964-3968
22. Warren SR, Yuan H, Matli RM, Gillett AN and Ferrara N (1995) Regulation by vascular endothelial growth factor of human colon cancer tumoirgenesis in a mouse model of experimental liver metastasis. J Clin Invest 95: 1789-1797