The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis

Mechanisms of Development

Volumn 66, Issue 1-2, 1997, Pages 69-81

  Hodgson, Jacob W ^a   Cheng, Niansheng Nick ^a   Sinclair, Donald A R ^b   Kyba, Michael ^a   Randsholt, Neel B ^c   Brock, Hugh W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

^c CNRS   (France)

Author keywords

Chromatin; Determination; Polycomb group

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO DEVELOPMENT; GENE LOCUS; HOMEOBOX; MUTATION; NONHUMAN; POLYTENE CHROMOSOME; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; NUCLEOPROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0343416803     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(97)00091-9     Document Type: Article

References (50)

1. Al-Atia, G.R., Fruscoloni, P. and Jacobs-Lorena, M. (1985) Translational regulation of mRNAs for ribosomal proteins during early Drosophila development. Biochemistry 24, 5798-5803.
2. Alberts, B. and Sternglanz, R. (1990) Chromatin contract to silence. Nature 344, 193-194.
3. Baumgartner, S., Bopp, D., Burri, M. and Noll, M. (1987) Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis. Genes Dev. 1, 1247-1267.
4. Bornemann, D., Miller, E. and Simon, J. (1996) The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein. Development 122, 1621-1630.
5. Campos-Ortega, J.A. and Hartenstein, V. (1985) The Embryonic Development of Drosophila melanogaster, Springer-Verlag, Berlin.
6. Chiang, A., O'Connor, M.B., Paro, R., Simon, J. and Bender, W. (1995) Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex. Development 121, 1681-1689.
7. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
8. Coleman, K.G., Poole, S.J., Weir, M.P., Soeller, W.C. and Kornberg, T. (1987) The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene. Genes Dev. 1, 19-28.
9. Deatrick, J. (1992) Localization of in situ polyhomeotic transcripts in Drosophila embryos reveals spatially restricted expression beginning at the blastoderm stage. Dev. Genet. 13, 326-330.
10. Deatrick, J., Daly, M., Randsholt, N.B. and Brock, H.W. (1991) The complex genetic locus polyhomeotic in Drosophila melanogaster potentially encodes two homologous zinc-finger proteins. Gene 105, 185-195.
11. DeCamillis, M. and Brock, H.W. (1994) Expression of the polyhomeotic locus in development of Drosophila melanogaster. Roux's Arch. Dev. Biol. 203, 429-438.
12. DeCamillis, M.A., Cheng, N., Pierre, D. and Brock, H.W. (1992) The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome binding sites with Polycomb. Genes Dev. 6, 223-232.
13. Dura, J.-M., Brock, H.W. and Santamaria, P. (1985) Polyhomeotic: a gene in Drosophila melanogaster required for correct expression of segment identity. Mol. Gen. Genet. 198, 220-231.
14. Dura, J.-M., Randsholt, N.B., Deatrick, J., Erk, I., Santamaria, P., Freeman, D.J., Freeman, S.F., Weddell, D. and Brock, H.W. (1987) Maternal and zygotic requirement for polyhomeotic, a genetically complex locus required for normal expression of segmental identity and cuticular development. Cell 51, 829-839.
15. Eissenberg, J.C., James, T.C., Foster-Hartnett, D.M., Hartnett, T., Ngan, V. and Elgin, S.C.R. (1990) Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 87, 9923-9927.
16. Fauvarque, M.-O. and Dura, J.-M. (1993) polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes Dev. 7, 1508-1520.
17. Fauvarque, M.-O., Zuber, V. and Dura, J.-M. (1995) Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. Mech. Dev. 52, 343-355.
18. Franke, A., DeCamillis, M.A., Zink, D., Cheng, N., Brock, H.W. and Paro, R. (1992) Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11, 2941-2950.
19. Gaunt, S.J. and Singh, P.B. (1990) Homeogene expression patterns and chromosomal imprinting. Trends Genet. 6, 208-212.
20. Heberlein, U., England, B. and Tjian, R. (1985) Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene. Cell 41, 965-977.
21. Henikoff, S. (1984) Unidirectional digestion with Exonuclease III creates targeted breakpoints for DNA sequencing. Gene 28, 351-359.
22. Jones, R.S. and Gelbart, W.M. (1990) Genetic analysis of the Enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. Genetics 126, 185-199.
23. Karpen, G.H. (1994) Position-effect variegation and the new biology of heterochromatin. Curr. Opin. Genet. Dev. 4, 281-291.
24. Lindsley, D.L. and Zimm, G.G. (1992) The Genome of Drosophila melanogaster, Academic Press, New York.
25. Lonie, A., D'Andrea, R., Paro, R. and Saint, R. (1994) Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Development 120, 2629-2636.
26. Lupas, A., Van Dyke, M. and Stock, J. (1991) Predicting coiled coils from protein sequences. Science 252, 1162-1164.
27. Martin, E.C. and Adler, P.N. (1993) The Polycomb group gene Posterior sex combs encodes a chromosomal protein. Development 117, 641-655.
28. Maxam, A. and Gilbert, W. (1977) A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74, 560-564.
29. McKeon, J. and Brock, H.W. (1991) Interactions of the Polycomb group of genes with homeotic loci of Drosophila. Roux's Arch. Dev. Biol. 199, 387-396.
30. Nomura, M., Takihara, Y. and Shimada, K. (1994) Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation 57, 39-50.
31. Oh, S.-Y., Scott, M.P. and Sarnow, P. (1992) Homeotic gene Antennapedia mRNA contains 5′-non-coding sequences that confer translational initiation by internal ribosome binding. Genes Dev. 6, 1643-1653.
32. Parker, C.S. and Topol, J. (1984) A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity. Cell 36, 357-369.
33. Paro, R. (1990) Imprinting a determined state into the chromatin of Drosophila. Trends Genet. 6, 416-421.
34. Paro, R. and Hogness, D.S. (1991) The Polycomb protein shares a homologous domain with a heterochromatin-associated protein in Drosophila. Proc. Natl. Acad. Sci. USA 88, 263-267.
35. Paro, R. and Zink, B. (1992) The Polycomb gene is differentially regulated during oogenesis and embryogenesis of Drosophila melanogaster. Mech. Dev. 40, 37-46.
36. Pirotta, V. (1995) Chromatin complexes regulating gene expression in Drosophila. Curr. Opin. Genet. Dev. 5, 466-472.
37. Rastelli, L., Chan, C.S. and Pirotta, V. (1993) Related chromosome binding sites for zeste, suppressor of zeste and Polycomb group protein and their dependence on Enhancer of zeste function. EMBO J. 12, 1513-1522.
38. Saget, O. and Randsholt, N.B. (1994) Transposon-induced rearrangements in the duplicated locus ph of Drosophila melanogaster can create new chimeric genes functionally identical to wild-type. Gene 149, 227-235.
39. Sambrook, I., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, Laboratory Press, USA.
40. Sanger, F., Nicklen, S. and Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
41. Sato, D. and Powell, D.J. (1982) Purification of the mRNAs encoding the subunits of the larval serum proteins 1 and 2 of Drosophila melanogaster. Eur. J. Biochem. 128, 199-207.
42. Serrano, N., Brock, H.W., Demeret, C., Dura, J.-M., Randsholt, N.B., Kornberg, T.B. and Maschat, F. (1995) polyhomeotic is a target of Engrailed regulation in Drosophila. Development 121, 1691-1703.
43. Simmonds, A.J., Brook, W.J., Cohen, S.M. and Bell, J.B. (1994) Distinguishable functions for engrailed and invected in the Drosophila wing. Nature 376, 424-427.
44. Simon, J. (1995) Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7, 376-385.
45. Simon, J., Peifer, M., Bender, W. and O'Connor, M.B. (1990) Regulatory elements of the bithorax complex that mediate repression by Polycomb group products. EMBO J. 9, 3945-3956.
46. Skeath, J.B., Zhang, Y., Holmgren, R., Carroll, S.B. and Doe, C.Q. (1995) Specification of neuroblast identity in the Drosophila embryonic central nervous system by gooseberry-distal. Nature 376, 427-430.
47. Struhl, G. and Akam, M.E. (1985) Altered distribution of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila. EMBO J. 4, 3259-3264.
48. Tabata, T., Schwartz, C., Gustavson, E., Ali, Z. and Kornberg, T.B. (1995) Creating a Drosophila wing de novo, the role of engrailed and the compartment border hypothesis. Development 121, 3359-3369.
49. Wampler, S.L., Tyree, C.M. and Kadonaga, J.T. (1990) Fractionation of the general RNA polymerase II transcription factors from Drosophila embryos. J. Biol. Chem. 265, 21223-21231.
50. Zink, B. and Paro, R. (1989) In vivo binding pattern of a trans-regulator of the homeotic genes in Drosophila melanogaster. Nature 337, 468-471.