A polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the drosophila bithorax complex

Genetics

Volumn 146, Issue 4, 1997, Pages 1365-1380

  Hagstrom, Kirsten ^a   Muller, Martin ^a,b   Schedl, Paul ^a  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN;

ARTICLE; DROSOPHILA; EMBRYO; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE STRUCTURE; HOMEOBOX; NONHUMAN; PRIORITY JOURNAL; SILENCER GENE;

ALLELES; ANIMALS; CHROMATIN; CROSSES, GENETIC; DNA; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EYE COLOR; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, INSECT; GENETIC COMPLEMENTATION TEST; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HOMOZYGOTE; INSECT PROTEINS; MALE; MUTATION; TRANSCRIPTION FACTORS;

EID: 0030749506     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. ASHBURNER, M., 1989 Drosophila: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. BENSON, M., and V. PIRROTTA, 1988 The Drosophila zeste protein binds cooperatively to sites in many gene regulatory regions: implications for transvection and gene regulation. EMBO J. 12: 1387-1392.
3. BHAT, K. M., G. FARKAS, F. KARCH, H. GYURKOVICS, J. GAUSZ et al., 1996 The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division. Development 122: 1113-1124.
4. BIGGIN, M. D., and R. TJIAN, 1988 Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts. Cell 53: 699-711.
5. BRAND, A. H., L. BREEDEN, J. ABRAHAM, R. STERNGLANZ and K. NASMYTH 1985 Characterization of a 'silencer' in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer. Cell 41: 41-48.
6. BREEN, T. R., and I. DUNCAN, 1986 Maternal expression of genes that regulate the bithorax complex of Drosophila melanogster. Dev. Biol. 118: 442-456.
7. BUSTURIA, A., and M. BIENZ, 1993 Silencers in ahdominal-B, a homeotic Drosophila gene. EMBO J. 12: 1415-1425.
8. CASARES, F., and E. SANCHEZ-HERRERO, 1995 Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes. Development 121: 1855-1866.
9. CHAN, C. S., L. RASTELLI and V. PIRROTTA, 1994 A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J. 13: 2553-2564.
10. CHIANG, A., M. B. O'CONNOR, R. PARO, J. SIMON and W. BENDER, 1995 Discrete Polycomb binding sites in each parasegmental domain of the bithorax complex. Development 121: 1681-1689.
11. CHINWALLA, V., E. P. JANE and P. J. HARTE, 1995 The Drosophila Trithorax protein binds to specific chromosomal sites and is colocalized with Polycomb at many sites. EMBO J. 14: 2056-2065.
12. CROSTON, G. E., L. A. KERRIGAN, L. M. LIRA, D. R. MARSHAK and J. T. KADONAGA, 1991 Sequence-specific antirepression of histone H1-mediated inhibition of basal RNA polymerase II transcription. Science 251: 643-649.
13. DIMITRI, P., and C. PISANO, 1989 Position effect variegation in Drosophila: relationship between suppression effect and the amount of Y chromosome. Genetics 122: 793-800.
14. DORER, D. R., and S. HENIKOFE, 1994 Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77: 993-1002.
15. DUNCAN, I., 1987 The bithorax complex. Annu. Rev. Genet. 21: 285-319.
16. FARKAS, G., J. GAUSZ, M. GALLONI, G. REUTER, H. GYURKOVICS et al., 1994 The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371: 806-808.
17. FAUVARQUE, M. O., and J. M. DURA, 1993 polyhomeotic regulatory sequences induce developmental-regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes Dev. 52: 343-355.
18. GALLONI, M., H. GYURKOVICS, P. SCHEDL and F. KARCH, 1993 The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex. EMBO J. 12: 1087-1097.
19. GELBART, W. M., and C-T. WU, 1982 Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster. Genetics 102: 179-189.
20. GINDHART, J. G., JR., and T. C. KAUFMAN, 1995 Identification of Poly- comb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced. Genetics 139: 797-814.
21. GLASER, R. L., G. THOMAS, E. S. SIEGFRIED, S. C. R. ELGIN and J. LIS, 1990 Optimal heat-induced expression of the Drosophila hsp26 gene requires a promoter sequence containing (CT)n (GA)n repeats. J. Mol. Biol. 211: 751-761.
22. GOWEN, J. W., and E. H. GAY, 1933 Effect of temperature on ever- spoting eye color in Drosophila melanogaster. Science 77: 312.
23. GRANOK, H., B. A. LEIBOVITCH, C. D. SHAFFER and S. G. R. ELGIN, 1995 Ga-ga over GAGA factor. Curr. Biol. 5: 238-241.
24. GRAY, S., and M. LEVINE, 1996 Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila. Genes Dev. 10: 700-710.
25. GYURKOVICS, H., J. GAUSZ, J. KUMMER and F. KARCH, 1990 A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation. EMBO J. 9: 2579-2585.
26. HAGSTROM, K., M. MULLER and P. SCHEDL, 1996 Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex. Genes Dev. 10: 3203-3215.
27. HAZELRIGG, T., and S. PETERSON, 1992 An unusual genomic position effect on Drosophila white gene expression: pairing-dependence, interactions with zeste, and molecular analysis of revenants. Genetics 130: 125-138.
28. HENIKOFF, S., 1990 Position-effect variegation after 60 years. Trends Genet. 6: 422-426.
29. INGHAM, P. W., and A. MARTINEZ ARIAS, 1986 The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene. Nature 324: 7592-7597
30. JACK, J. W., and B. H. JUDD, 1979 Allelic pairing and gene regulation: a model for the zeste-white interaction in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 76: 1368-1372.
31. JACKSON, M., 1991 Negative regulation of eukaryotic transcription. J. Gell Sci. 100: 1-7.
32. JOHNSON, A. D., 1995 The price of repression. Cell 81: 655-658.
33. KAPOUN, A. M., and T. C. KAUFMAN, 1995 Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairing. Genetics 140: 643-658.
34. KARCH, F., M. GALLONI, L. SIPOS, J. GAUSZ, H. GYURKOVICS et al., 1994 Mcp and Fab-7: molecular analysis of putative boundaries of cis-regulalory domains in the bithorax complex of Drosophila melanogaster. Nucleic Acids Res. 22: 3138-3146.
35. KARCH, F., B. WEIFFENBACH, M. PEIFER, W. BENDER, I. DUNCAN et al., 1985 The abdominal region of the bithorax complex. Cell 43: 81-96.
36. KASSIS, J. A., 1994 Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region. Genetics 136: 1025-1038.
37. KASSIS, J. A., E. P. VANSICKLE and S. M. SENSABAUGH, 1991 A fragment of engrailed regulatory DNA can mediate transvection of the white gene in Drosophila. Genetics 128: 751-761.
38. KELLUM, R., and P. SCHEDL., 1991 A position-effect assay for boundaries of higher order chromosomal domains. Cell 64: 941-950.
39. KENNISON, J. A., 1993 Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet. 9: 75-78.
40. KENNISON, J. A., and M. A. RUSSEL, 1987 Dosage-dependent modifiers of homeotic mutations in Drosophila melanogaster. Genetics 116: 75-86.
41. KENNISON, J. A., and J. W. TAMKUN, 1988 Dosage dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. USA 85: 8136-8140.
42. LANEY, J. D., and M. D. BIGGIN, 1992 zeste, a non-essential gene, potently activates Ultrabithorax transcription in the Drosophila embryo. Genes Dev. 6: 1531-1541.
43. LAURENSON, P., and J. RINE, 1992 Silencers, silencing, and heritable transcription states. Microbiol. Rev. 56: 543-560.
44. LEVIS, R., T. HAZELRIGG and G. M. RUBIN, 1985 Separable cis-acting control elements for expression of the white gene of Drosophila melanogaster. EMBO J. 4: 3489-3499.
45. LEWIS, E. B., 1954 The theory and application of of a new method for detecting chromosomal rearrangements in Drosophila melano- gaster. Am. Nat. 88: 225-239.
46. LEWIS, E. B., 1978 A gene complex controlling segmentation in Drosophila. Nature 276: 565-570.
47. LU, Q., L. L. WALLRATH, H. GRANOK and S. C. R. ELGIN, 1993 (CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene. Mol. Cell. Biol. 13: 2802-2814.
48. MIHALY, J., I. HOGGA, J. GAUSZ, H. GYURKOVICS and F. KARCH, 1997 In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element. Development 124: 1809-1820.
49. MOEHRLE, A., and R. PARO, 1994 Spreading the silence: epigenetic transcriptional regulation during Drosophila development. Dev. Genet. 15: 478-484.
50. MÜLLER, J., and M. BIENZ, 1991 Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo. EMBO J. 10: 3147-3155.
51. O'HARE, K., C. MURPHY, R. LEVIS and G. RUBIN, 1984 DNA sequence of the white locus of Drosophila melanogaster. J. Mol. Biol. 180: 437-455.
52. PARO, R., 1990 Imprinting a determined state into the chromatin of Drosophila. Trends Genet. 6: 416-421.
53. PATEL, N., 1994 Chapter 24, pp. 446-487 in Methods in Cell Biology, edited by L. S. B. GOLDSTEIN and E. A. FRYBERG. Academic Press, New York.
54. PIRROTTA, V., 1991 The genetics and molecular biology of zeste in Drosophila melanogaster. Adv. Genet. 29: 301-348.
55. PIRROTTA, V., and L. RASTELLI, 1994 white gene expression, repressive chromatin domains, and homeotic gene regulation in Drosophila. BioEssays 16: 549-556.
56. PIRROTTA, V. H., H. STELLER and M. P. BOZZETTI, 1985 Multiple upstream regulatory elements control the expression of the Drosophila white gene. EMBO J. 4: 3501-3508.
57. Poux, S., C. KOSTIC and V. PIRROTTA, 1996 Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response element. EMBO J. 15: 4713-4722.
58. REUTER, G., and P. SPIERER, 1992 Position effect variegation and chromatin proteins. BioEssays 14: 605-612.
59. SHIMELL, M. J., J. SIMON, W. BENDER and M. B. O'CONNOR 1994 Enhancer point mutation results in a homeotic transformation in Drosophila. Science 264: 1968-1971.
60. SIMON, J., 1995 Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7: 376-385.
61. SIMON, J., A. CHIANG, W. BENDER, M. J. SHIMELL and M. O'CONNOR, 1993 Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev. Biol. 158: 131-144.
62. SIMON, J., M. PEIFER, W. BENDER and M. O'CONNOR, 1990 Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis. EMBO J. 9: 3945-3956.
63. SOELLER, W. G., C. E. OH and T. B. KORNBERG, 1993 Isolation of cDNAs encoding the Drosophila GAGA transcription factor. Mol. Cell. Biol. 13: 7961-7970.
64. SPOFFORD, J. B., 1976 Position effect variegation in Drosophila, pp. 955-1018 in The Genetics and Biology of Drosophila, edited by MASHBURNER and E. NOVITSKI. Academic Press, New York.
65. TARTOF, K., and S. HENIKOFF, 1991 Trans-sensing effects from Drosophila to humans. Cell 65: 201-203.
66. TSUKIYAMA, T., P. B. BECKER and C. Wu, 1994 ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature 367: 525-532.
67. VAZQUEZ, J., G. FARKAS, M. GASZNER, A. UDVARDY, M. MULLER et al., 1993 Genetic and molecular analysis of chromatin domains. Cold Spring Harb. Symp. Quant. Biol. 58: 45-54.
68. VAZQUEZ, J., and P. SCHEDL, 1994 Sequences required for enhancer blocking activity of scs are located within two nuclease-hypersen- sitive regions. EMBO J. 13: 5984-5993.
69. WHITE, R. A. H., and R. LEHMANN, 1986 A gap gene, hunchback, regulates the spatial expression of Ultrabithorax. Cell 47: 311-321.
70. Wu, C. T., 1993 Transvection, nuclear structure, and chromatin proteins. J. Cell. Biol. 120: 587-590.
71. ZHOU, J., S. BAROLO, P. SZYMANSKI and M. LEVINE, 1996 The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo. Genes Dev. 10: 3195-3201.
72. ZINK, D., and R. PARO, 1995 Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA. EMBO J. 14: 5660-5671.