Dopa decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study

Journal of Neuroscience

Volumn 18, Issue 15, 1998, Pages 5901-5907

  Ernst, Monique ^a,b   Zametkin, Alan J ^a   Matochik, John A ^a   Jons, Peter H ^a   Cohen, Robert M ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

(F18)fluorodopa; Attention deficit hyperactivity disorder; Gender; Neurodevelopment; Nigrostriatal pathways; PET; Prefrontal cortex; Presynaptic dopaminergic function

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; FLUORINE 18;

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; FEMALE; GENDER; HUMAN; MALE; MESENCEPHALON; NIGRONEOSTRIATAL SYSTEM; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL;

EID: 0032146143     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-15-05901.1998     Document Type: Article

References (50)

1. Abercrombie ED, Bonatz AE, Zigmond MJ (1990) Effects of L-dopa on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats. Brain Res 525:36-44.
2. Alagarsamy S, Phillips M, Pappas T, Johnson KM (1997) Dopamine neurotoxicity in cortical neurons. Drug Alcohol Depend 48:105-111.
3. Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357-381.
4. American Academy of Child and Adolescent Psychiatry (1997) Practice parameters for the assessment and treatment of children, adolescents, and adults with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36:85S-121S.
5. American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R), 3rd ed, Revised. Washington, DC: American Psychiatric Association.
6. Amin F, Davidson M, Davis KL (1992) Homovanillic acid measurement in clinical research: a review of methodology. Schizophr Bull 18:123-148.
7. Aylward EH, Reiss AL, Reader MJ (1996) Basal ganglia volumes in children with attention-deficit hyperactivity disorder. J Child Neurol 11:112-115.
8. Barkley R (1990) Developmental course and adult outcome. In: Attention deficit hyperactivity disorder. A handbook for diagnosis and treatment, pp 114-129. New York: Guilford.
9. Barkley RA (1996) Attention-deficit hyperactivity disorder. In: Child psychopathology (Mash EJ, Barkley RA, eds), pp 63-112. New York: Guilford.
10. Bellak L, Black RB (1992) Attention-deficit hyperactivity disorder in adults. Clin Ther 14:138-147.
11. Benton A (1991) Prefrontal injury and behavior in children. Dev Neuropsychol 7:275-282.
12. Bourgeois JP, Goldman-Rakic PS, Rakic P (1994) Synaptogenesis in the prefrontal cortex of rhesus monkeys. Cereb Cortex 4:78-96.
13. Caparulo BK, Cohen DJ, Rothman SL, Young JG, Katz JD, Shaywitz SE, Shaywitz BA (1981) Computed tomographic brain scanning in children with developmental neuropsychiatrie disorders. J Am Acad Child Adolesc Psychiatry 20:338-357.
14. Castellanos FX (1997) Toward a pathophysiology of attention-deficit hyperactivity disorder. Clin Pediatr (Phila) 36:381-393.
15. Castellanos FX, Elia J, Kruesi MJP, Gulotta CS, Mefford IN, Potter WZ, Ritchie GF, Rapoport JL (1994) Cerebrospinal fluid monoamine metabolites in boys with attention deficit hyperactivity disorder. Psychiatry Res 52:305-316.
16. Castellanos FX, Giedd JN, Marsh WL (1996) Quantitative brain magnetic resonance imaging in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 53:607-616.
17. Changeux JP, Danchin A (1976) Selective stabilization of developing synapses as a mechanism for the specification of neuronal networks. Nature 264:705-712.
18. Chugani HT, Phelps ME, Mazziotta JC (1987) Positron emission tomography study of human brain functional development. Ann Neurol 22:487-497.
19. Clark CR, Geffen GM, Geffen LB (1986) Role of monoamine pathways in the control of attention: effects of droperidol and methylphenidate in normal adult humans. Psychopharmacology 90:28-34.
20. Conners CK (1969) A teacher rating scale for use in drug studies with children. Am J Psychiatry 126:884-888.
21. Cook EH, Stein MA, Krasowski MD (1995) Association of attention deficit disorder and the dopamine transporter gene. Am J Hum Genet 56:993-998.
22. Cowan WM, Fawcett JW, O'Leary DD, Stanfield BB (1984) Regressive events in neurogenesis. Science 225:1258-1265.
23. DeLong MR, Alexander GE, Miller WC, Crutcher MD (1990) Anatomical and functional aspects of basal ganglia-thalamocortical circuits. In: Function and dysfunction in the basal ganglia (Franks AJ, Ironside JW, Mindham RHS, Smith RJ, Spokes EGS, Winlow W, eds), pp 3-32. Manchester, UK: Manchester UP.
24. Denckla MB (1994) Measurement of executive function. In: Frames of reference for the assessment of learning disabilities: new views on measurement issues (Lyon GR, ed), pp 117-142. Baltimore: Brookes.
25. Doudet DJ, Aigner TG, McLellan CA, Cohen RM (1992a) Positron emission tomography with 18-F-dopa: interpretation and biological correlates in non-human primates. Psychiatry Res 45:153-168.
26. Doudet DJ, McLellan CA, Aigner TG, Wyatt RJ, Cohen RM (1992b) Delayed L-phenylalanine infusion allows for simultaneous kinetic analysis and improved evaluation of specific-to-nonspecific fluorine-18-dopa uptake in brain. J Nucl Med 33:1383-1389.
27. Downey KK, Stelson FW, Pomerleau OF, Giordani B (1997) Adult attention deficit hyperactivity disorder: psychological test profiles in a clinical population. J Nerv Ment Dis 185:32-38.
28. Endicott J, Spitzer RL (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837-844.
29. Ernst M (1998) Dopaminergic function in ADHD. In: Dopaminergic disorders: novel approaches for drug discovery and development, pp 235-260. Southborough, MA: IBC.
30. Ernst M, Liebenauer LL, King AC, Fitzgerald GA, Cohen RM, Zametkin AJ (1994) Reduced brain metabolism in hyperactive girls. J Am Acad Child Adolesc Psychiatry 33:858-868.
31. Ernst M, Zametkin A, Matochik J, Pascualvaca D, Jons P, Hardy K, Hankerson J, Doudet D, Cohen R (1996) Presynaptic dopaminergic deficits in Lesch-Nyhan disease. N Engl J Med 334:1568-1604.
32. Ernst M, Cohen RM, Liebenauer LL, Jons PH, Zametkin AJ (1997a) Cerebral glucose metabolism in adolescent girls with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36:1399-1406.
33. Ernst M, Liebenauer LL, Tebeka D, Jons PH, Eisenhofer G, Murphy DL, Zametkin AJ (1997b) Selegiline in ADHD adults. II. Plasma monoamines and monoamine metabolite. Neuropsychopharmacology 16:276-284.
34. Gershon ES, DeLisi LE, Hamovit J, Nurnberger JIJ, Maxell ME, Schreiber J, Dauphinais D, Dingman CWI, Guroff JJ (1988) A controlled family study of chronic psychosis. Arch Gen Psychiatry 45:328-336.
35. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M (1997) Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313.
36. Gittelman R, Mannuzza S, Shenker R, Bonagura N (1985) Hyperactive boys almost grown up. I. Psychiatric status. Arch Gen Psychiatry 42:937-947.
37. Gjedde A, Reith J, Dyve S, Léger G, Guttman M, Diksic M, Evans A, Kuwabara H (1991) Dopa decarboxylase activity of the living human brain. Proc Natl Acad Sci USA 88:2721-2725.
38. Gjedde A, Léger GC, Cumming P, Yasuhara Y, Evans AC, Guttman M, Kuwabara H (1993) Striatal L-dopa decarboxylase activity in Parkinson's disease in vivo: implications for the regulation of dopamine synthesis. J Neurochem 61:1538-1541.
39. Goldman-Rakic PS (1992) Dopamine-mediated mechanisms of the prefrontal cortex. Semin Neurosci 4:149-159.
40. Goyette CH, Conners CK, Ulrich RF (1978) Normative data on revised Conners parent and teacher rating scales. J Abnorm Child Psychol 6:221-236.
41. Graybiel AM (1991) Basal ganglia - input, neural activity, and relation to the cortex. Curr Opin Neurobiol 1:644-651.
42. Hadjiconstantinou M, Wemlinger TA, Sylvia CP, Hubble JP, Neff NH (1993) Aromatic L-amino acid decarboxylase activity of mouse striatum is modulated via dopamine receptors. J Neurochem 60:2175-2180.
43. Heilman KM, Voeller KKS, Nadeau SE (1991) A possible pathophysiologic substrate of attention deficit hyperactivity disorder. J Child Neurol 6:S76-S81.
44. Huttenlocher PR (1979) Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res 163:195-205.
45. Hynd GW, Hern KL, Novey ES (1993) Attention deficit hyperactivity disorder and asymmetry of the caudate nucleus. J Child Neurol 8:339-347.
46. King D, Finlay J (1995) Effects of selective dopamine depletion in medial prefrontal cortex on basal and evoked extracellular dopamine in neostriatum. Brain Res 685:117-128.
47. LaHoste GJ, Swanson JM, Wigal SB (1996) Dopamine D4 receptor gene polymorphisms associated with attention deficit hyperactivity disorder. Mol Psychiatry 1:121-124.
48. Levitt P, Harvey JA, Friedman E, Simansky K, Murphy EH (1997) New evidence for neurotransmitter influences on brain development. Trends Neurosci 20:269-274.
49. Lewis DA, Sesack SR, Levey AI, Rosenberg DR (1998) Dopamine axons in primate prefrontal cortex: specificity of distribution, synaptic targets, and development. Adv Pharmacol 42:703-706.
50. Lou HC (1991) Cerebral glucose metabolism in hyperactivity. N Engl J Med 324:1216-1217.