Effects of supplementation with iloprost on the cardioprotection by BW755C (a dual inhibitor of cyclooxygenase and lipoxygenase enzymes) in myocardial reperfusion injury

Pharmacological Research

Volumn 36, Issue 2, 1997, Pages 103-108

  Maulik, M ^a   Seth, S D ^a   Maulik, S K ^a   Manchanda, S C ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

BW755C; Iloprost; Myocardial reperfusion injury

Indexed keywords

3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; ADENOSINE TRIPHOSPHATE; GLYCOGEN; ILOPROST; LIPOXYGENASE INHIBITOR; PROSTACYCLIN DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 0031214024     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0177     Document Type: Article

References (19)

1. 1. Menasche P. The inflammatory response to cardiopulmonary bypass and its impact on post operative myocardial function. Curr Opin Cardiol 1995; 10: 597-604.
2. 2. Curtis MJ, Pugsley MK, Walker MJA. Endogenous chemical mediators of ventricular arrhythmias in ischaemic heart disease. Cardiovasc Res 1993; 27: 703-19.
3. 3. Allen SP, Yacoub MH. Role of leukotrienes in coronary artery surgery. Curr Opin Cardiol 1995; 10: 605-13.
4. 2 in postischaemic recovery of stunned canine myocardium. Circulation 1988; 78: 450-61.
5. 5. Seth SD, Maulik M, Manchanda SC, Maulik SK. Role of aspirin in modulating ischaemic reperfusion injury. Agents Actions 1994; 41: 151-5.
6. 6. Brine K, Peskar BA. Modulation by drugs of leukotriene and prostaglandin production from mouse peritonial macrophages. Int J Tiss Res 1985; VII: 97-103.
7. 7. Amsterdam EA, Pan HL, Rendig SV, Symons JD, Fletcher MP, Longhurst JC. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent inhibition of neutrophil activity without reduction of neutrophil migration. J Am Coll Cardiol 1993; 22: 1738-44.
8. (+) ATP channel-opening. Agents Actions 1995; 45:(Suppl.) 93-9.
9. 9. Apstein CS, Deckelbaum L, Hagopian L Hood WB Jr. Acute cardiac ischemia and reperfusion contractility relaxation and glycolysis. Am J Physiol 1978; 4: H637-48.
10. 10. Lamprecht W. Stein F. Weisser H. Heinz F. Determination of creatine phosphate and adenosine triphosphate with creatine kinase and glyceraldehyde phosphate dehydrogenase. In: Bergmeyer HU, Ed. Methods of Enzymatic Analysis. New York: Academic Press, 1974: 1776-8.
11. 11. Siu LO, Russel JC, Taylor AW. Determination of glycogen in small tissue samples. J Appl Physiol 1970; 28: 234-6.
12. 12. Gawehr K. Bergmeyer HU. Lactate determination. In: Bergmeyer HU, Ed. Methods of Enzymatic Analysis. New York: Academic Press, 1974: 1492-5.
13. 13. Tanaka M, Brooks SE, Richard VJ, Fitzharris GP, Stoler RC, Jennings RB, Arfors KE, Remier KA. Effect of anti CD 18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 1993; 87: 526-35.
14. 14. Raschke P, Massoudy P, Becker BF. Taurine protects the heart from neutrophil induced reperfusion injury. Free Radic Biol Med 1995; 19: 461-71.
15. 15. Kanzig I, Cakici I, Ersoy S, Ark M, Abacioglu N, Zengil H. Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and hemodynamics in guinea-pigs. Pharmacol Res 1992; 26: 305-16.
16. 16. Maulik M, Seth SD, Manchanda, SC, Maulik SK. Lack of any additional benefits in combining aspirin with iloprost in a canine model of myocardial reperfusion injury. Prostaglandins 1997: in press.
17. 17. Ribeiro LGT, Reduto LA, Brandon TA, Taylor AA, Hopkins DG, Miller RR. Effects of prostacyclin on hemodynamics, regional myocardial blood flow, infarct size and mortality in experimental myocardial infarction. Clin Res 1979; 27: 199A.
18. 18. Farber NE, Pieper GH, Thomas JP, Garret JG. Beneficial effects of iloprost in the stunned canine myocardium. Circ Res 1988; 62: 204-15.
19. 19. Parrat JR. Endogenous myocardial protective antiarrhythmic substance. Cardiovasc Res 1993; 27: 693-702.