The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals

Molecular and Cellular Biology

Volumn 21, Issue 14, 2001, Pages 4505-4514

  Zhang, B ^a   Egli, D ^a   Georgiev, O ^a   Schaffner, W ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; HEAVY METAL; SCAVENGER; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; GENE CONTROL; GENE INDUCTION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; HUMAN CELL; METAL BINDING; METAL METABOLISM; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CATIONS, DIVALENT; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA; HUMANS; INSECT PROTEINS; MAMMALS; METALLOTHIONEIN; METALS, HEAVY; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; ZINC FINGERS;

EUKARYOTA; LETHRINIDAE; MAMMALIA; VERTEBRATA;

EID: 0034948931     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.14.4505-4514.2001     Document Type: Article

References (60)

1. The genome sequence of Drosophila melanogaster
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response
4. Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1
5. Embryonic lethality and liver degeneration in mice lacking the relA component of NF-κB
6. Tine DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals
7. Functional heterogeneity in the zinc fingers of the metalloregulatory transcription factor, MTF-1
8. Developmental variability of metallothionein Min gene expression in the species of the Drosophila melanogaster subgroup
9. Response of Drosophila metallothionein promoters to metallic, heat shock anal oxidative stresses
10. Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells
11. MRE-Binding transcription factor-1: Weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex
12. Genomic sequencing
13. Disorders of copper transport
14. Metallothionein in snail Cd and Cu metabolism
15. Reversible activation of mouse metal response element-binding transcription factor 1 DNA binding involves zinc interaction with the zinc finger domain
16. Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-1 gene promoter
17. Characterization of the MTF-1 transcription factor from zebrafish and trout cells
18. Metals and cellular signaling in mammalian cells
19. Expression of metallothionein genes during the post-embryonic development of Drosophila melanogaster
20. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
21. The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye
22. Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1
23. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
24. The transcription factor MTF-1 is essential for basal and heavy metalinduced metallothionein gene expression
25. c-Jun is essential for normal mouse development and hepatogenesis
26. Drosophila jun relays the jun amino-terminal kinase signal transduction pathway to the decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement
27. Chemistry and biochemistry of metallothionein
28. Overview of metallothionein
29. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration
30. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
31. Heritable gene silencing in Drosophila using double-stranded RNA
32. Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways
33. Drosophila she gene product is implicated in signaling by the DER receptor tyrosine kinase
34. Nucleotide sequence and expression of a Drosophila metallothionein
35. Molecular and cytogenetic characterization of a metallothionein gene of Drosophila
36. Metallothionein genes in Drosophila melanogaster constitute a dual system
37. Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1
38. A DNA segment controlling metal-regulated expression of the Drosophila melanogaster metallothionein gene Min
39. Cloning anal functional characterization of a mammalian zinc transporter that confers resistance to zinc
40. MT-III, a brain-specific member of the metallothionein gene family
41. Functional domains of the heavy metal-responsive transcription regulator MTF-1
42. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter
43. Common and distinct roles of DFos and DJun during Drosophila development
44. Gene targeting by homologous recombination in Drosophila
45. Nucleo-cytoplasmic trafficking of metal-responsive transcription factor MTF-1 is regulated by diverse stress signals
46. Cell tines derived from late embryonic stages of Drosophila melanogaster
47. Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells
48. Metal regulatory elements of the mouse metallothionein-I gene
49. Metallothionein Mto gene of Drosophila melanogaster: Structure and regulation
50. Metallothionein in human disease
51. Zinc and cadmium can promote rapid nuclear translocation of metal response element-binding transcription factor-1
52. Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences
53. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
54. Mapping of RNA by a modification of the Berk-Sharp procedure: The 5′ termini of 15 S beta-globin mRNA precursor and matute 10 S beta-globin mRNA have identical map coordinates
55. A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene
56. OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts
57. Heavy metal-mediated activation of the rat Cu/Zn superoxide dismutase gene via a metal-responsive element
58. Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila for mutants