Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1

EMBO Journal

Volumn 17, Issue 10, 1998, Pages 2846-2854

  Günes, Ćagatay ^a   Heuchel, Rainer ^a   Georgiev, Oleg ^a   Müller, Karl Heinz ^a   Lichtlen, Peter ^a   Blüthmann, Horst ^b   Marino, Silvia ^c   Aguzzi, Adriano ^c   Schaffner, Walter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Glutathione biosynthesis; Knockout mice; Liver degeneration; Metallothionein gene expression; Transcription factor MTF 1

Indexed keywords

CADMIUM; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEAVY METAL; HEAVY METAL RESPONSIVE TRANSCRIPTIONAL ACTIVATOR; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METALLOTHIONEIN; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; EMBRYO; EMBRYO DEATH; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE LOCUS; HOMEOSTASIS; LIVER CELL; LIVER DEVELOPMENT; MOUSE; MOUSE MUTANT; NONHUMAN; OXIDATION REDUCTION STATE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STRESS;

ANIMALS; CADMIUM; CELLS, CULTURED; DIPEPTIDES; DNA-BINDING PROTEINS; EDEMA; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DISEASES; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE TARGETING; GLUTATHIONE SYNTHASE; HYDROGEN PEROXIDE; LIVER; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; TRANSCRIPTION FACTORS;

EID: 33646935780     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.10.2846     Document Type: Article

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