The impact of ex vivo cytokine stimulation on engraftment of primitive hematopoietic cells in a non-human primate model

Annals of the New York Academy of Sciences

Volumn 938, Issue , 2001, Pages 236-245

  Dunbar, Cynthia E ^a   Takatoku, Masaaki ^a   Donahue, Robert E ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Cell cycle; Homing; Stem cells

Indexed keywords

CYTOKINE; FLT3 LIGAND; GROWTH FACTOR; STEM CELL FACTOR;

ANIMAL CELL; APOPTOSIS; AUTOTRANSPLANTATION; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; GENE THERAPY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOSTIMULATION; MACACA; MEGAKARYOCYTE; NONHUMAN;

EID: 0034943202     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03594.x     Document Type: Conference Paper

References (20)

1. Gene transfer into hematopoietic stem cells of nonhuman primates
2. Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability
3. Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor
4. + progenitors using clinically feasible methods
5. Many multi-potential gene-marked progenitor or stem cell clones contribute to hematopoiesis in non-human primates
6. + cells in non-obese diabetic/severe combined immune-deficient mice
7. - cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
8. Ex-vivo expansion of hematopoietic stem and progenitor cells: Robbing Peter to pay Paul?
9. The fluctuating phenotype of the lymphohematopoietic stem cell with cell cycle transit
10. Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells
11. Growth-supporting activities of fibronectin on hematopoietic stem/progenitor cells in vitro and in vivo: Structural requirements for fibronectin activities of CS1 and cell-binding domains
12. Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells
13. Retroviral marking and transplantation of rhesus hematopoietic cells by nonmyeloablative conditioning
14. + cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or non mobilized with granulocyte colony-stimulating factor and/or stem cell factor
15. Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells
16. Stem cell factor and hematopoiesis
17. Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle
18. Adhesion receptor expression by hematopoietic cell lines and murine progenitors: Modulation by cytokines and cell cycle status
19. Organ selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by ex vivo expansion
20. - human hematopoietic cells by HIV-1-based lentiviral vectors