The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF

Leukemia

Volumn 12, Issue 3, 1998, Pages 353-362

  Metcalf, D ^a   Mifsud, S ^a   Di Rago, L ^a   Robb, L ^a   Nicola, N A ^a   Alexander, W ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Granulocyte macrophage colony stimulating factor; Homozygous inactivation; Membrane receptors; Tissue pathology; Transgenic

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; LUNG ALVEOLUS PROTEINOSIS; MOUSE; NONHUMAN; PERITONEUM CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; TRANSGENIC MOUSE;

EID: 0031933269     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400926     Document Type: Article

References (26)

1. Gammeltoft S, Kahn CR. Hormone signaling via membrane receptors. In: De Groot LJ (ed). Endocrinology, 3rd edn. Saunders: Philadelphia, 1995, pp 17-65.
2. Delwell R, Van Buitenen C, Salem M, Bot F, Gillis S, Kaushansky K, Altrock B, Löwenberg R. Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release. Blood 1989; 74: 586-593.
3. Dührsen U, Stahl J, Cough NM. In vivo transformation of factor-dependent hemopoietic cells: role of intracisternal A-particle transposition for growth factor gene activation. EMBO J 1990; 9: 1087-1096.
4. Metcalf D, Rasko JEJ. Leukemic transformation of immortalized FDC-P1 cells engrafted in GM-CSF transgenic mice. Leukemia 1993; 7: 878-886.
5. Metcalf D, Nicola NA. The Hemopoietic Colony-stimulating Factors: from Biology to Clinical Applications. Cambridge University Press: Cambridge, 1995.
6. Metcalf D, Burgess AW, Johnson GR, Nicola NA, Nice EC, DeLamarter J, Thatcher DR, Mermod J-J. In vitro actions on hemopoietic cells of recombinant murine GM-CSF purifed after production in Eschericha coli: comparison with purified native GM-CSF. J Cell Physiol 1986; 128: 421-431.
7. Golde DW, Ding DX, Rivas CI, Vera JC. The colony-stimulating factors and molecular transport. Stem Cells 1994; 12 (Suppl.): 61-66.
8. Metcalf D, Elliott MJ, Nicola NA. The excess numbers of peritoneal macrophages in granulocyte-macrophage colony-stimulating factor transgenic mice are generated by local proliferation. J Exp Med 1992; 175: 877-884.
9. Lang RA, Metcalf D, Cuthbertson RA, Lyons I, Stanley E, Kelso A, Kannourakis G, Williamson DJ, Klintworth GK, Gonda TJ, Dunn AR. Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness and a fatal syndrome of tissue damage. Cell 1987; 51: 675-686.
10. Metcalf D, Moore JG. Divergent disease patterns in GM-CSF transgenic mice associated with differing transgene insertion sites. Proc Natl Acad Sci USA 1988; 85: 7767-7771.
11. Robb L, Drinkwater CC, Metcalf D, Li R, Köntgen F, Nicola N, Begley CG. Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci USA 1995; 92: 9565-9569.
12. Metcalf D, Willson TA, Hilton DJ, Di Rago L, Mifsud S. Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays. Leukemia 1995; 9: 1556-1564.
13. Alexander WS, Schrader JW, Adams JM. Expression of the c-myc oncogene under control of an immunoglobulin enhancer in Eμ-myc transgenic mice. Mol Cell Biol 1987; 7: 1436-1444.
14. Nicola NA, Metcalf D. Binding of iodinated multipotential colony-stimulating factor (interleukin-3) to murine bone marrow cells. J Cell Physiol 1986; 128: 180-188.
15. Metcalf D, Nicola NA. Tissue localization and fate in mice of injected multipotential colony-stimulating factor. Proc Natl Acad Sci USA 1988; 85: 3160-3164.
16. Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA, Mulligan RC. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 1994; 264: 713-716.
17. Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JAM, Maher DW, Cebon J, Sinickas V, Dunn AR. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci USA 1994; 91: 5592-5596.
18. Gearing A, Metcalf D, Moore JC, Nicola NA. Elevated levels of GM-CSF and IL-1 in the serum, peritoneal and pleural cavities of GM-CSF transgenic mice. Immunol 1989; 67: 216-220.
19. Tushinski RJ, Oliver IT, Guilbert LJ, Tynan PW, Warner JN, Stanley ER. Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 1982; 28: 71-81.
20. Layton JE, Hockman H, Sheridan WB, Morstyn G. Evidence for a novel in vivo control mechanism of granulopoiesis: mature cell-related control of a regulatory growth factor. Blood 1989; 74 1303-1307.
21. Kuter DJ, Rosenberg RD. The reciprocal relationship of thrombopoietin (c-mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in rabbits. Blood 1995; 85: 2720-2730.
22. Nicola NA, Smith A, Robb L, Metcalf D, Begley CG. The structural basis of the biological actions of the GM-CSF receptor. In: Bock GR, Goode JA (eds). The Molecular Basis of Cellular Defence Mechanisms. Wiley: Chichester (Ciba Foundation Symposium 204) 1997, pp 19-32.
23. Lang RA, Metcalf D, Cough NM, Dunn AR, Gonda TJ. Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell 1985; 43: 531-542.
24. Gearing DP, King JA, Cough NM, Nicola NA. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J 1989; 8: 3667-3676.
25. Lang RA, Cuthbertson RA, Dunn AR. TNFα, IL-1α and bFGF are implicated in the complex disease of GM-CSF transgenic mice. Growth Factors 1992; 6: 131-138.
26. Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Cell Invest 1996; 97: 649-655.