Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen are excluded from the liver that expresses transgene-encoded hepatitis B surface antigen

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 4235-4243

  Schirmbeck, Reinhold ^a   Wild, Jens ^a   Stober, Detlef ^a   Blum, Hubert E ^b   Chisari, Francis V ^c   Geissler, Michael ^b   Reimann, Jörg ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B SURFACE ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENE;

EID: 0034655133     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.4235     Document Type: Article

References (62)

1. Chisari, F. V. 1997. Cytotoxic T cells and viral hepatitis. J. Clin. Invest. 99:1472.
2. Milich, D. R. 1987. Genetic and molecular basis for T-and B-cell recognition of hepatitis B viral antigens, Immunol. Rev. 99:71.
3. Jin, Y., J. W. K. Shih, and I. Berkower. 1988. Human T cell response to the surface antigen of hepatitis B virus (HBsAg): endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen. J. Exp. Med. 168:293.
4. Barnaba, V., A. Franco, A. Alberti, R. Benvenuto, and F. Balsano. 1990. Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes. Nature 345:258.
5. Ellis, R. W. 1990. New and improved vaccines against hepatitis B. I. Recombinant-derived vaccines against hepatitis B. In New Generation Vaccines. G. C. Woodrow and M. M. Levine, eds. Dekker, New York, p. 439.
6. Ferrari, C., M. Pilli, A. Penna, A. Bertoletti, A. Valli, A. Cavalli, G. Pasetti, and F. Fiaccadori. 1992. Autopresentation of hepatitis B virus envelope antigens by T cells. J. Virol. 66:2536.
7. Chisari, F. V. 1993. The role of cytotoxic T lymphocytes and inflammatory cytokines in the pathogenesis of acute viral hepatitis. Gastroenterol. Jpn. 28(Suppl.4):2.
8. Ando, K.-I., L. G. Guidotti, A. Cerny, T. Ishikawa, and F. V. Chisari. 1994. CTL access to tissue antigen is restricted in vivo. J. Immunol. 153:482.
9. Ando, K.-I., L. G. Guidotti, A. Cerny, T. Ishikawa, and F. V. Chisari. 1994. Access to antigen restricts cytotoxic T lymphocyte function in vivo. J. Immunol. 152:3245.
10. Schirmbeck, R., K. Melber, T. Mertens, and J. Reimann. 1994. Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen. Eur. J. Immunol. 24:1088.
11. + cytotoxic T lymphocyte responses in vivo. J. Immunol. 152:1110.
12. Shouval, D., Y. Ilan, R. Adler, R. Deepen, A. Panet, C. Z. Even, M. Gorecki, and W. H. Gerlich. 1994. Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines. Vaccine 12:1453.
13. Böhm, W., R. Schirmbeck, A. Elbe, K. Melber, D. Diminsky, G. Kraal, N. Van Rooijen, Y. Barenholz, and J. Reimann. 1995. Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo. J. Immunol. 155: 3313.
14. Michel, M.-L., H. L. Davis, M. Schleef, M. Mancini, P. Tiollais, and R. G. Whalen. 1995. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc. Natl. Acad. Sci. USA 92:5307.
15. Schirmbeck, R., W. Böhm, K. Melber, and J. Reimann. 1995. Processing of exogenous heat-aggregated (denatured) or paniculate (native) hepatitis B surface antigen for class I-restricted epitope presentation. J Immunol. 155:4676.
16. Schirmbeck, R., K. Melber, and J. Reimann. 1995. Hepatitis B virus surface particles are processed in a novel endosomal pathway for MHC class I-restricted epitope presentation. Eur. J. Immunol. 25:1063.
17. Schirmbeck, R., W. Böhm, K.-I. Ando, F. V. Chisari, and J. Reimann. 1995. Nucleic acid vaccination primes hepatitis B surface antigen-specific cytotoxic T lymphocytes in nonresponder mice. J. Virol. 69:5929.
18. Davis, H. L., M. Mancini, M.-L. Michel, and R. G. Whalen. 1996. DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost. Vaccine 14:910.
19. Davis, H. L., M. J. McCluskie, J. L. Gerin, and R. H. Purcell. 1996. DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc. Natl. Acad. Sci. USA 93:7213.
20. Rehermann, B., D. Lau, J. H. Hoofnagle, and F. V. Chisari. 1996. Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J. Clin. Invest. 97:1655.
21. Davis, H. L., R. Weeranta, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870.
22. Geissler, M., K. Tokushige, T. Wakita, V. R. Zurawski, Jr., and J. R. Wands. 1998. Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs. Vaccine 16:857.
23. Schirmbeck, R., J. Wild, and J. Reimann. 1998. Similar as well as distinct MHC-I-binding peptides are generated by exogenous and endogenous processing of hepatitis B virus surface antigen (HBsAg). Eur. J. Immunol. 28:4149.
24. Wild, J., B. Grüner, K. Metzger, A. Kuhröber, H.-P. Pudollek, H. Hauser, R. Schirmbeck, and J. Reimann. 1998. Polyvalent vaccination against hepatitis B surface and core antigen using dicistronic expression plasmids. Vaccine 16:353.
25. Chisari, F. V., K. Klopchin, T. Moriyama, C. Pasquinelli, H. A. Dunsdorf, S. Sell, C. A. Pinkert, R. L. Brinster, and R. D. Palmiter. 1989. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59:1145.
26. Moriyama, T., S. Guilhot, K. Klopchin, B. Moss, C. A. Pinkert, R. D. Palmiter, R. L. Brinster, O. Kanagawa, and F. V. Chisari. 1990. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 248:361.
27. Chisari, F. V. 1991. Analysis of hepadnavirus gene expression, biology, and pathogenesis in the transgenic mouse. Curr. Top. Microbiol. Immunol. 168:85.
28. Guidotti, L. G., K.-I. Ando, M. V. Hobbs, T. Ishikawa, L. Runkel, R. D. Schreiber, and F. V. Chisari. 1994. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Natl. Acad. Sci. USA 91:3764.
29. Guidotti, L. G., B. Matzke, H. Schaller, and F. V. Chisari. 1995. High-level hepatitis B virus replication in transgenic mice. J. Virol. 69:6158.
30. Huang, S. N., and F. V. Chisari. 1995. Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology 21:620.
31. Mancini, M., M. Hadchouel, H. L. Davis, R. G. Whalen, P. Tiollais, and M.-L. Michel. 1996. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. Proc. Natl. Acad. Sci. USA 93: 12496.
32. Guidotti, L. G., B. Matzke, C. Pasquinelli, J. M. Schoenberger, C. E. Rogler, and F. V. Chisari. 1996. The Hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice. J. Virol. 70:7056.
33. Cavanaugh, V. J., L. G. Guidotti, and F. V. Chisari. 1997. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J. Virol. 71:3236.
34. Janowicz, Z. A., K. Melber, A. Merckelbach, E. Jacobs, N. Harford, M. Comberbach, and C. P. Hollenberg. 1991 Simultaneous expression of the S and L surface antigens of hepatitis B. and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha. Yeast 7:431.
35. + T cell-dependent. J. Immunol. 163:1880.
36. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M.-D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, E. Raz, and M. D. Nguyen. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization Science 273:352.
37. Davis, H. L., R. Schirmbeck, J. Reimann, and R. G. Whalen. 1995. DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to Hepatitis B virus surface antigen. Hum. Gene Ther. 6:1447.
38. Böhm, W., A. Kuhröber, T. Paier, T. Mertens, J. Reimann, and R. Schirmbeck. 1996. DNA vector constructs that prime hepatitis B surface antigen-specific cytotoxic T lymphocytes and antibody responses in mice after intramuscular injection. J. Immunol. Methods 193:29.
39. Böhm, W., T. Mertens, R. Schirmbeck, and J. Reimann. 1998. Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses. Vaccine 16:949.
40. b-restricted epitope processed from exogenous but not endogenous hepatitis B surface antigen Int. Immunol. 11:1093.
41. Cobbold, S. P., A. Jayasuriya, A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548.
42. Wirth, S., L. G. Guidotti, K.-I. Ando, H. J. Schlicht, and F. V. Chisari. 1995. Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice. J. Immunol. 154:2504.
43. Mancini, M., M. Hadchouel, P. Tiollais, and M.-L. Michel. 1998. Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgentc mouse model by IFN-γ-secreting T cells after DNA-based immunization. J. Immunol. 161:5564.
44. Pol, S., I. Couillin, M.-L. Michel, F. Driss, B. Nalpas, F. Carnot, P. Berthelot, and C. Brechot. 1998 Immunotherapy of chronic hepatitis B by anti HBV vaccine. Acta Gastro-enterol. Belg. 61:228.
45. Farza, H., A. M. Salmon, M. Hadchouel, J. L. Moreau, C. Babinet, P. Tiollais, and C. Pourcel. 1987. Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice. Proc. Natl. Acad. Sci. USA 84:1187.
46. Hadchouel, M., H. Farza, D. Simon, P. Tiollais, and C. Pourcel. 1987. Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature 329:454.
47. Pourcel, C., P. Tiollais, and H. Farza. 1990. Transcription of the S gene in transgenic mice is associated with hypomethylation at specific sites and with DNase I sensitivity. J. Virol. 64:931.
48. Schweizer, J., S. P. Valenza, F. Goret, and C. Pourcel. 1998. Control of expression and methylation of a hepatitis B virus transgene by strain-specific modifiers, DNA Cell Biol. 17:427.
49. Shimizu, Y., L. G. Guidotti, P. Fowler, and F. V. Chisari. 1998. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. J. Immunol. 161:4520.
50. Ando, K.-I., T. Moriyama, L. G. Guidotti, S. Wirth, R. D. Schreiber, H.-J. Schlicht, S.-N. Huang, and F. V. Chisari. 1993. Mechanisms of class I restricted immunopathology: a transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178:1541.
51. Ando, K.-I., L. G. Guidotti, S. Wirth, T. Ishikawa, G. Missale, T. Moriyama, R. D. Schreiber, H. J. Schlicht, S. N. Huang, and F. V. Chisari. 1994. Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. J. Immunol. 152:3245.
52. Guidotti, L. G., T. Ishikawa, M. V. Hobbs, B. Matzke, R. Schreiber, and F. V. Chisari. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25.
53. Franco, A., L. G. Guidotti, M. V. Hobbs, V. Pasquetto, and F. V. Chisari. 1997. Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J. Immunol. 159:2001.
54. Gilles, P. N., D. L. Guerrette, R. J. Ulevitch, R. D. Schreiber, and F. V. Chisari. 1992. HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon-γ. Hepatology 16:655.
55. Cavanaugh, V. J., L. G. Guidotti, and F. V. Chisari. 1998. Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice. J. Virol. 72:2630.
56. Arnold, B., O. Dill, G. Kublbeck, L. Jatsch, M. M. Simon, J. Tucker, and G. J. Hämmerling. 1988. Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form. Proc. Natl. Acad. Sci. USA 85:2269.
57. Arnold, B., M. Messerle, L. Jatsch, G. Kublbeck, and U. Koszinowski. 1990. Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen. Proc. Natl. Acad. Sci. USA 87:1762.
58. Arnold, B., and G. J. Hämmerling. 1991. MHC class-I transgenic mice. Annu. Rev. Immunol. 9:297.
59. Hämmerling, G. J., G. Schönrich, F. Momburg, N. Auphan, M. Malissen, B. Malissen, V. A. Schmitt, and B. Arnold. 1991. Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen. Immunol. Rev. 122:47.
60. Limmer, A., T. Sacher, J. Alferink, M. Kretschmar, G. Schonrich, T. Nichterlein, B. Arnold, and G. J. Hämmerling. 1998. Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment. Eur. J. Immunol. 28:2395.
61. b in the liver. Eur. J. Immunol. 25:1932.
62. + T lymphocytes but fail to promote survival. Eur. J. Immunol. 28:221.