Ligand Recognition by β3 Integrins

Keio Journal of Medicine

Volumn 46, Issue 3, 1997, Pages 111-114

  Suehiro, Kazuhisa ^a   Plow, Edward F ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Divalent cations; Fibrinogen; Integrins; Ligands; Platelet membrane glycoproteins

Indexed keywords

BETA3 INTEGRIN; FIBRINOGEN RECEPTOR; INTEGRIN; LEUKOCYTE ANTIGEN; LIGAND;

CROSS REACTION; METABOLISM; REVIEW;

ANTIGENS, CD; CROSS REACTIONS; INTEGRIN BETA3; INTEGRINS; LIGANDS; PLATELET MEMBRANE GLYCOPROTEINS;

EID: 0031228320     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.46.111     Document Type: Review

References (31)

1. Hynes RO: Integrins: a family of cell surface receptors. Cell 1987; 48: 549-554
2. Ginsberg MH, Loftus JC, Plow EF: Cytoadhesins, integrins, and platelets. Thromb Haemost 1988; 59: 1-6
3. Luscinskas FW, Lawler J: Integrins as dynamic regulators of vascular function. FASEB J 1994; 8: 929-938
4. Felding-Habermann B, Cheresh DA: Vitronectin and its receptors. Curr Opin Cell Biol 1993; 5: 864-868
5. Brooks PC, Clark RA, Cheresh DA: Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264: 569-571
6. Liaw L, Skinner MP, Raines EW, Ross R, Cheresh DA, Schwartz SM, Giachelli CM; The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J Clin Invest 1995; 95: 713-724
7. Plow EF, McEver RP, Coller BS, Woods VL Jr, Marguerie GA, Ginsberg MH: Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. Blood 1985; 66: 724-727
8. Thiagarajan P, Kelly KL: Exposure of binding sites for vitronectin on platelets following stimulation. J Biol Chem 1988; 263: 3035-3038
9. Lawler J, Weinstein R, Hynes RO: Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol 1988; 107: 2351-2361
10. Charo IF, Nannizzi L, Smith JW, Cheresh DA: The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin. J Cell Biol 1990; 111: 2795-2800
11. D'Souza SE, Ginsberg MH, Burke TA, Lam SC, Plow EF: Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science 1988; 242: 91-93
12. Smith JW, Cheresh DA: The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit. J Biol Chem 1988; 263: 18726-18731
13. Smith JW, Ruggeri ZM, Kunicki TJ, Cheresh DA: Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990; 265: 12267-12271
14. D'Souza SE, Ginsberg MH, Burke TA, Plow EF: The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. J Biol Chem 1990; 265: 3440-3446
15. Scarborough RM, Rose JW, Hsu MA, Phillips DR, Fried VA, Campbell AM, Nannizzi L, Charo IF: Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri. J Biol Chem 1991; 266: 9359-9362
16. Scarborough RM, Naughton MA, Teng W, Rose JW, Phillips DR, Nannizzi L, Arfsten A, Campbell AM, Charo IF: Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa. J Biol Chem 1993; 268: 1066-1073
17. Ruoslahti E, Pierschbacher MD: New perspectives in cell adhesion: RGD and integrins. Science 1987; 238: 491-497
18. Smith JW, Cheresh DA: Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD Binding site on the vitronectin receptor. J Biol Chem 1990; 265: 2168-2172
19. Smith JW, Cheresh DA: Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding. J Biol Chem 1991; 266: 11429-11432
20. D'Souza SE, Haas TA, Piotrowicz RS, Byers-Ward V, McGrath DE, Soule HR, Cierniewski C, Plow EF, Smith JW: Ligand and cation binding are dual functions of a discrete segment of the integrin beta 3 subunit: cation displacement is involved in ligand binding. Cell 1994; 79: 659-667
21. Smith JW, Piotrowicz RS, Mathis D: A mechanism for divalent cation regulation of beta 3-integrins. J Biol Chem 1994; 269: 960-967
22. Suehiro K, Gailit J, Plow EF: Fibrinogen is a ligand for integrin alpha(5)beta(1) on endothelial cells. J Biol Chem 1997; 272: 5360-5366
23. Bazzoni G, Shih DT, Buck CA, Hemler ME: Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem 1995; 270: 25570-25577
24. 2+ binding site on the beta3-integrins that regulates the dissociation rate for RGD ligands. J Biol Chem 1996; 271: 21745-21751
25. Loftus JC, O'Toole TE, Plow EF, Glass A, Frelinger AL 3d, Ginsberg MH: A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 1990; 249: 915-918
26. Lee JO, Rieu P, Arnaout MA, Liddington R: Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/ CD18). Cell 1995; 80: 631-638
27. Suehiro K, Smith JW, Plow EF: The ligand recognition specificity of beta3 integrins. J Biol Chem 1996; 271: 10365-10371
28. D'Souza SE, Ginsberg MH, Matsueda GR, Plow EF: A discrete sequence in a platelet integrin is involved in ligand recognition. Nature 1991; 350: 66-68
29. 2+ suppresses cell adhesion to osteopontin by attenuating binding affinity for integrin alpha v beta 3. J Biol Chem 1995; 270: 9917-9925
30. Bennett JS, Chan C, Vilaire G, Mousa SA, Degrado WF: Agonist-activated alpha v beta 3 on platelets and lymphocytes binds to the matrix protein osteopontin. J Biol Chem 1997; 272: 8137-8140
31. Kunicki TJ, Annis DS, Feldinghabermann B: Molecular determinants of ARG-GLY-ASP ligand specificity for beta(3) integrins. J Biol Chem 1997; 272: 4103-4107