A piston model for transmembrane signaling of the aspartate receptor

Science

Volumn 285, Issue 5434, 1999, Pages 1751-1754

  Ottemann, Karen M ^a,b   Xiao, Wenzhong ^a   Shin, Yeon Kyun ^a   Koshland Jr , Daniel E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; MEMBRANE RECEPTOR;

ARTICLE; CONFORMATIONAL TRANSITION; LIGAND BINDING; MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ASPARTIC ACID; BACTERIAL PROTEINS; CELL MEMBRANE; CHEMOTAXIS; DIMERIZATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FOURIER ANALYSIS; LIGANDS; LIPID BILAYERS; MEMBRANE PROTEINS; METHYLATION; MODELS, BIOLOGICAL; MUTAGENESIS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, AMINO ACID; SIGNAL TRANSDUCTION; SPIN LABELS;

BACTERIA (MICROORGANISMS);

EID: 0033543590     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5434.1751     Document Type: Article

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55. Supported by NIH grant DK09765 and the William Keck Foundation (D.E.K.), NIH grant GM51290 and a Searle Scholarship (Y.-K.S.), and a Burroughs Wellcome Fund Career Award in the Biomedical Sciences (K.M.O.). We thank J. Falke for the coordinates of the modeled transmembrane domain aspartate receptor and S. Doyle, S. Marqusee, E. Strauss, and Z. Zhu for comments on the manuscript.