The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities

Mechanisms of Development

Volumn 106, Issue 1-2, 2001, Pages 85-96

  Millet, Caroline ^a   Lemaire, Patrick ^b   Orsetti, Béatrice ^c   Guglielmi, Paul ^d   François, Vincent ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

^b AIX MARSEILLE UNIVERSITÉ   (France)

^c INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^d INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

Bone morphogenetic proteins; Chordin; Human; Splice variants

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CHORDIN; DNA FRAGMENT;

ALTERNATIVE RNA SPLICING; DROSOPHILA; EMBRYO DEVELOPMENT; GASTRULATION; GENE EXPRESSION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA SYNTHESIS; SEQUENCE ANALYSIS;

INVERTEBRATA; VERTEBRATA;

EID: 0034914813     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(01)00423-3     Document Type: Article

References (57)

1. The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo
2. Local inhibition and long-range enhancement of Dpp signal transduction by Sog
3. The organizer factors Chordin and Noggin are required for mouse forebrain development
4. The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm
5. Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation
6. Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates
7. Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene
8. Twisted gastrulation can function as a BMP antagonist
9. Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila
10. BMP signalling in early Xenopus development
11. Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo
12. Sequence, biochemical characterization, and developmental expression of a new member of the TGF-beta superfamily in Drosophila melanogaster
13. Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region
14. The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4
15. Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
16. Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo
17. Patterning the zebrafish axial skeleton requires early chordin function
18. Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation
19. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene
20. In situ hybridization: an improved whole-mount method for Xenopus embryos
21. Bone morphogenetic proteins in development
22. Bone morphogenetic proteins: mutifunctional regulators of vertebrate development
23. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin
24. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities
25. Characterization of the human thrombopoietin gene promoter. A possible role of an Ets transcription factor, E4TF1/GABP
26. Gastrulation in zebrafish: what mutants teach us
27. BMP-binding modules in chordin: a model for signalling regulation in the extracellular space
28. Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins
29. Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor
30. Bone morphogenetic proteins in the nervous system
31. Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning
32. Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV
33. The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling
34. A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family
35. Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes
36. Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters
37. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4
38. Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity
39. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
40. Twisted gastrulation is a conserved extracellular BMP antagonist
41. Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes
42. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
43. Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning
44. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis
45. Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain
46. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling
47. A functional bone morphogenetic protein system in the ovary
48. Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes
49. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo
50. Growth factors in the extracellular matrix
51. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
52. Regulation of BMP signaling by the BMP1/TLD-related metalloprotease, SpAN
53. Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins
54. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity
55. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
56. Short gastrulation, a mutation causing delays in stage-specific cell shape changes during gastrulation in Drosophila melanogaster