Local inhibition and long-range enhancement of Dpp signal transduction by Sog

Nature

Volumn 398, Issue 6726, 1999, Pages 427-431

  Ashe, Hilary L ^a   Levine, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DROSOPHILA; EMBRYO DEVELOPMENT; GASTRULATION; GENE ACTIVITY; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL PROTEINS; BODY PATTERNING; CARRIER PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYONIC INDUCTION; ENHANCER ELEMENTS (GENETICS); FEMALE; GTP-BINDING PROTEINS; HOMEODOMAIN PROTEINS; INSECT PROTEINS; MALE; PROTEINS; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; XENOPUS;

ARACHNIDA; HEXAPODA;

EID: 0033119776     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/18892     Document Type: Article

References (28)

1. Ferguson, E. L. & Anderson, K. V. decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71, 451-461 (1992).
2. Wharton, K. A., Ray, R. P. & Gelbart, W. M. An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo. Development 117, 807-822 (1993).
3. François, V., Solloway, M., O'Neill, J. W., Emery, J. & Bier, E. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 8, 2602-2616 (1994).
4. Shimell, M. J., Ferguson, E.. L., Childs, S. R. & O'Connor, M. B. The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1. Cell 67, 469-481 (1991).
5. Marques, G. et al. Production of a Dpp activity gradient in the early Drosophila embryo through the opposing actions of the Sog and Tld proteins. Cell 91, 417-426 (1997).
6. Neul, J. L. & Ferguson, E. L. Spatially restricted activation of the Sax receptor by Scw modulates Dpp/ Tkv signalling in Drosophila dorsal-ventral patterning. Cell 95, 483-494 (1998).
7. Nguyen, M., Park, S., Marques, G. & Arora, K. Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signalling by two type I receptors, Sax and Tkv. Cell 95, 495-506 (1998).
8. Zusman, S. B., Sweeton, D. & Wieschaus, E. F. short gastrulation, a mutation causing delays in stage specific cell shape changes during gastrulation in Drosophila melanogaster. Dev. Biol. 129, 417-427 (1988).
9. Kosman, D. & Small, S. Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps. Development 124, 1343-1354 (1997).
10. Smith, W. C. & Harland, R. M. Expression cloning of noggin, a new dorsalising factor localized to the spemann organizer in Xenopus embryos. Cell 70, 829-840 (1992).
11. Jiang, J., Kosman, D., Ip, Y. T. & Levine, M. The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev. 5, 1881-1891 (1991)
12. Tatei, K., Cai, H., Ip, Y. T. & Levine, M. Race: a Drosophila homologue of the angiotensin converting enzyme. Mech. Dev. 51, 157-168 (1995).
13. Rusch, J. & Levine, M. Regulation of a dpp target gene in the Drosophila embryo. Development 124, 303-311 (1997).
14. Arora, K., Levine, M. S. & O'Connor, M. B. The screw gene encodes a ubiquitously expressed member of the TGF-β family required for specification of dorsal cell fates in the Drosophila embryo. Genes Dev. 8, 2588-2601 (1994).
15. Konrad, K. D., Goralski, T. J., Mahowald, A. P. & Marsh, J. L. The gastrulation-defective gene of Drosophila melanogaster is a member of the serine protease superfamily. Proc. Natl Acad. Sci. USA 95, 6819-6824 (1998).
16. Roth, S., Stein, D. & Nusslein-Volhard, C. A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell 59, 1189-1202 (1989).
17. Rusch, J. & Levine, M. Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo. Curr. Opin. Genet. Dev. 6, 416-423 (1996).
18. Piccolo, S. et al. Cleavage of chordin by xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell 91, 407-416 (1997).
19. Holley, S. A. et al. The Xenopus dorsalizing factor noggin ventralises Drosophila embryos by preventing Dpp from activating its receptor. Cell 86, 607-617 (1996).
20. Lewis, J., Slack, J. M. & Wolpert, L. Thresholds in development J. Theor. Biol. 65, 579-590 (1977).
21. McDowell, N., Zorn, A. M., Crease, D. J. & Gurdon, J. B. Activin has direct long-range signalling activity and can form a concentration gradient by diffusion. Curr. Biol. 7, 671-681 (1997).
22. Jones, C. M., Armes, N. & Smith, J. C. Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin. Curr. Biol. 6, 1468-1475 (1996).
23. Nellen, D., Burke, R., Struhl, G. & Basler, K. Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368 (1996).
24. Lecuit, T. et al. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393 (1996).
25. Ferguson, E. L. & Anderson, K. V. Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo. Development 114, 583-597 (1992).
26. Holley, S. A. et al. A conserved system for dorsal-ventral patterning in insects and vertebrates involving Sog and chordin. Nature 376, 249-253 (1995).
27. Rubin, G. & Spradling, A. Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353 (1982).
28. Tautz, D. & Pfeifle, C. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals a translational control of the segmentation gene hunchback. Chromosoma 98, 81-85 (1989).