Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region

Development

Volumn 128, Issue 6, 2001, Pages 965-972

  Dorfman, R ^a   Shilo, B Z ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

BMP; Dpp; Drosophila melanogaster; Embryonic patterning; Mad; Screw; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CELL RECEPTOR; INSECT PROTEIN; LIGAND; METALLOPROTEINASE; PROTEIN ANTIBODY; PROTEIN MAD1; PROTEIN MAD2; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BLASTODERM; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DROSOPHILA; EMBRYO CELL; EMBRYO DEVELOPMENT; GASTRULATION; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BLASTODERM; BODY PATTERNING; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT PROTEINS; MORPHOGENESIS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

DROSOPHILA MELANOGASTER; HEXAPODA; INSECTA; MELANOGASTER;

EID: 0035067146     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo
2. Local inhibition and long-range enhancement of Dpp signal transduction by Sog
3. Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo
4. The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm
5. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
6. Msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm
7. Gradient Formation of the TGF-β Homolog Dpp
8. Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
9. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene
10. Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila
11. A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila
12. The role of brinker in mediating the graded response to Dpp in early Drosophila embryos
13. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
14. Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGF beta receptor family
15. Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins
16. Controlling TGF-beta signaling
17. Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
18. Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning
19. Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV
20. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
21. The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation
22. TGF-beta family signal transduction in Drosophila development: From Mad to Smads
23. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
24. A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
25. An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo
26. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
27. The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1
28. Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function
29. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs
30. Dpp gradient formation in the Drosophila wing imaginal disc
31. An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
32. A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster
33. The Drosophila saxophone gene: A serine-threonine kinase receptor of the TGF-beta superfamily
34. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta
35. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity
36. Short gastrulation, a mutation causing delays in stage-specific cell shape changes during gastrulation in Drosophila melanogaster