Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTpase activating protein, SynGAP

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 8, 2001, Pages 955-963

  Pei, Lin ^a   Teves, R Lucy ^b   Wallace, M Christopher ^b   Gurd, James W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Cerebral ischemia; Postsynaptic density; PSD 95; SH2 domain; SynGAP; Tyrosine phosphorylation

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SYNGAP; RAS PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOREBRAIN; HIPPOCAMPUS; IMMUNOPRECIPITATION; MALE; NEUROPATHOLOGY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION; TRANSIENT ISCHEMIC ATTACK;

EID: 0034910945     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200108000-00008     Document Type: Article

References (48)

1. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation
2. Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein
3. GTPase-activating protein interactions with the viral and cellular Src kinases
4. Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain
5. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II
6. Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemia in the rat brain
7. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
8. How MAP kinases are regulated
9. Stimulation of p21ras upon T-cell activation
10. A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation
11. New insights into the control of MAP kinase pathways
12. Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning
13. Procedures for analyzing the tyrosine phosphorylation of synaptic glycoproteins
14. The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-gamma
15. Tyrosine phosphorylation and activation of mitogen-activated protein kinase in the rat brain following transient cerebral ischemia
16. Assembly of proteins to postsynaptic densities after transient cerebral ischemia
17. Alteration of MAP kinase pathways after transient forebrain ischemia
18. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
19. Signal transduction molecules at the glutamatergic postsynaptic membrane
20. SynGAP: A synaptic RasGAP that associates with the PSD-95/SAP90 protein family
21. Delayed neuronal death in the gerbil hippocampus following ischemia
22. Regulation of c-Src tyrosine kinase activity by the Src SH2 domain
23. Protein measurement with the Folin phenol reagent
24. Calcium-dependent activation of protein kinase C. The role of the C2 domain in divalent cation selectivity
25. Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
26. Modification of postsynaptic densities after transient cerebral ischemia: A quantitative and three-dimensional ultrastructural study
27. Alterations of hippocampal postsynaptic densities following transient ischemia
28. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
29. Delayed hippocampal damage in humans following cardiorespiratory arrest
30. A new model of bilateral hemispheric ischemia in the unanesthetized rat
31. Temporal profile of neuronal damage in a model of transient forebrain ischemia
32. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
33. Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src
34. Association between GTPase activators for Rho and Ras families
35. Activation of the extracellular signal-regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning
36. Subcellular distribution and autophosphorylation of calcium/calmodulin- dependent protein kinase II-alpha in rat hippocampus in a model of ischemic tolerance
37. The plekstrin homology domain: An intriguing multifunctional protein module
38. Transient ischemia induces an early decrease of synaptic transmission in CA1 neurons of rat hippocampus: Electrophysiologic study in brain slices
39. NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain
40. Transient ischemia differentially increases tyrosine phosphorylation of NMDA receptor subunits 2A and 2B
41. The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: Possible involvement of Src homology 2 domains
42. Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia
43. Oncoproteins. GAPs in understanding Ras
44. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism
45. Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains
46. NMDA channel regulation by channel-associated protein tyrosine kinase Src
47. Transient global ischemia alters NMDA receptor expression in rat hippocampus: Correlation with decreased immunoreactive protein levels of the NR2A/B subunits, and an altered NMDA receptor functionality
48. Enlightening the postsynaptic density