Evolution of a molecular switch: Universal bacterial GtPases regulate ribosome function

Molecular Microbiology

Volumn 41, Issue 2, 2001, Pages 289-297

  Caldon Pauline Yoong, Catherine E ^a   March, Paul E ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DOCKING PROTEIN; ELONGATION FACTOR; ELONGATION FACTOR G; ELONGATION FACTOR LEPA; ELONGATION FACTOR TU; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; INITIATION FACTOR 2; PROTEIN ENGA; PROTEIN ERA; PROTEIN FFH; PROTEIN FTSY; PROTEIN OBG; PROTEIN TRME; PROTEIN YCHF; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CATALYSIS; CATALYST; CELL ACTIVITY; ENZYME ACTIVITY; GENETIC ANALYSIS; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RIBOSOME; RNA BINDING; RNA PROCESSING; SEQUENCE ANALYSIS; SHORT SURVEY;

BACTERIA; EVOLUTION, MOLECULAR; GTP PHOSPHOHYDROLASE-LINKED ELONGATION FACTORS; GTP PHOSPHOHYDROLASES; PROTEIN BIOSYNTHESIS; RIBOSOMES;

BACTERIA (MICROORGANISMS);

EID: 0034909325     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02536.x     Document Type: Short Survey

References (78)

1. Three dimensional structure of the ribosomal translocase: Elongation factor G from Thermus thermophilus
2. Molecular cloning and sequencing of the thdF gene, which is involved in thiophene and furan oxidation by Escherichia coli
3. Stress induced membrane association of the Streptococcusmutans GTP-binding protein, an essential G protein, and investigation of its physiological role utilizing an antisense RNA strategy
4. Crystal structure of active elongation factor Tu reveals major domain rearrangements
5. Functional substitution of the signal recognition particle 54 kD subunit by its Escherichia coli homolog
6. The complete genome sequence of Escherichia coli K-12
7. Selenocysteine: The 21st amino acid
8. GTPases: A family of molecular switches and clocks
9. The GTPase superfamily: A conserved switch of diverse cell functions
10. The GTPase superfamily: Conserved structure and molecular mechanism
11. Cell cycle arrest in Era GTPase mutants - A potential growth rate-regulated checkpoint in Escherichia coli
12. Initiation factors of protein biosynthesis in bacteria and their structural relationship to elongation and termination factors
13. Polypeptide chain release factors
14. DNA sequence analysis of 136 kilobases of the Escherichia coli genome: Organizational symmetry around the origin of replication
15. The Escherechia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionary conserved GTPase with unusual biochemical properties
16. Crystal structure of Era: A GTPase-dependent cell cycle regulator containing an RNA binding motif
17. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
18. MTO1 codes for a mitochondrial protein required for respiration in paramomycin-resistant mutants of Saccharomyces cerevisiae
19. The crystal structure of elongation factor G complexed with GDP, at 2.7Å resolution
20. A new essential gene of the 'minimal genome' affecting cell division
21. The complete genome of the hyperthermophilic bacterium Aquifex aeolicus
22. MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase
23. lep operon proximal gene is not required for growth or secretion by Escherichia coli
24. Molecular discrimination between Campylobacter jejuni, Campylobacter coli, Campylobacter lari and Campylobacter upsaliensis by polymerase chain reaction based on a novel putative GTPase gene
25. Rapid identification of diverse Campylobacter lari strain isolated from mussels and oysters using a reverse hybridization line probe assay
26. Small GTPases minireview series
27. Wholegenome random sequencing and assembly of Haemophilus influenzae Rd
28. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
29. The minimal gene complement of Mycoplasma genitalium
30. Complete genome sequence of Treponema pallidum, the syphilis spirochete
31. A GTP-binding protein (Era) has an essential role in growth rate and cell cycle control in Eschenchia coli
32. Initiation of mRNA translation in prokaryotes
33. The many faces of G protein signaling
34. Complementation of sporulation and motility defects in a prokaryote by a eukaryotic GTPase
35. Association of Escherichia coli ribosomes with the inner membrane requires the signal recognition particle receptor but is independent of the signal recognition particle
36. Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae
37. The genes lepA and hemNform a bicistronic operon in Bacillus subtilis
38. Relics from the RNA world
39. The widely conserved Era G-protein contains an RNA-binding domain required for Era function in vivo
40. Conformational changes involved in the activation of ras p21: Implications for related proteins
41. Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions
42. GUF1 a gene encoding a novel evolutionary conserved GTPase in yeast
43. Effects on Bacillus subtilis of a conditional lethal mutation in the essential GTP-binding protein Obg
44. Initiation factor IF2 stimulates ribosomal subunit association and binds to the alpha-sarcin loop and to helix 89 of 23S rRNA
45. Pleiotropic changes resulting from depletion of Era, an essential GTP-binding protein in Escherichia coli
46. The Caulobacter crescentus CgtA protein displays unusual guanine nucleotide binding and exchange properties
47. GTPase-dependent signaling in bacteria: Characterization of a membrane-binding site for Era in Escherichia coli
48. An alternative protein targeting pathway in Escherichia coli: Studies on the role of FtsY
49. Membrane-associated GTPases in bacteria
50. A homologue of the recombination-dependent growth gene, rdgC, is involved in gonococcal pilin antigenic variation
51. 16S rRNA is bound to Era of Streptococcus pneumoniae
52. Comparative genomics of prokaryotic GTP-binding proteins (the Era, Obg, EngA, ThdF (TrmE), YchF and Yih families) and their relationship to eukaryotic GTP-binding proteins (the DRG, ARF, RAB, RAN, RAS, and RHO families)
53. Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA
54. Leu
55. Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog
56. Tubulin and FtsZ form a distinct family of GTPases
57. An essential GTP-binding protein functions as a regulator for differentiation in Streptomyces coelicolor
58. The E. coli ffh gene is necessary for viability and efficient protein transport
59. Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli: Enzyme IIA-Ntr affects growth on organic nitrogen and the conditional lethality of an era-ts mutant
60. Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases
61. Dynamics of translation on the ribosome: Molecular mechanics of translocation
62. GTPase mechanisms and functions of translation factors on the ribosome
63. The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain
64. Era, an essential Escherichia colis mall G-protein, binds to the 30S ribosomal subunit
65. β
66. β stress response transcription factor cofractionate with ribosomes
67. FtsY, the prokaryotic signal recognition particle receptor homologue, is essential for biogenesis of membrane proteins
68. G-protein mechanisms: Insights from structural analysis
69. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis
70. The Bacillus subtilis spoOB stage 0 sporulation operon encodes an essential GTP-binding protein
71. The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins
72. Possible role for the essential GTP-binding protein Obg in regulating the initiation of sporulation in Bacillus subtilis
73. DNA sequence around the Escherichia coli unc operon: Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS
74. Biochemical characterization of the essential GTP-binding protein Obg of Bacillus subtilis
75. Molecular movement inside the translational engine
76. Characterization of a GTPase activity of TrinE, a member of a novel GTPase superfamily from Thermotoga maritima
77. Small clusters of divergent amino acids surrounding the effector domain mediate the varied phenotypes of EF-G and LepA expression
78. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence