Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast

Journal of Cell Science

Volumn 114, Issue 14, 2001, Pages 2641-2648

  Franke, J ^a   Reimann, B ^a   Hartmann, E ^a   Kohler M ^a   Wiedmann, B ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

NAC; Nuclear transport; Saccharomyces cerevisiae

Indexed keywords

KAP123P PROTEIN; KARYOPHERIN; NASCENT POLYPEPTIDE ASSOCIATED COMPLEX; NUCLEAR IMPORT FACTOR; POLYPEPTIDE; PROTEIN SUBUNIT; PSE1P PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; FLUORESCENCE MICROSCOPE; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RIBOSOME; STEADY STATE; STOICHIOMETRY; TRANSCRIPTION REGULATION; YEAST;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; CELL NUCLEUS; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE DELETION; GREEN FLUORESCENT PROTEINS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR CHAPERONES; MUTAGENESIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RIBOSOMES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL RECOGNITION PARTICLE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034897016     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
2. The α and β subunit of the nascent polypeptide- associated complex (NAC) have distinct functions
3. Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway
4. Yeast-enhanced green fluorescent protein (yEGFP)a reporter of gene expression in Candida albicans
5. Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria
6. The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo
7. Transport between the cell nucleus and the cytoplasm
8. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
9. Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo
10. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
11. The importin beta/importin 7 heterodimer is a functional import receptor for histone H1
12. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121
13. Evidence for distinct substrate specificities of importin α family members in nuclear import
14. Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex
15. The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent polypeptide-associated complex
16. Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum
17. The yeast nuclear import receptor is required for mitosis
18. Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids
19. A general mechanism for regulation of access to the translocon: Competition for a membrane attachment site on ribosomes
20. Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-jun mediated transcription
21. The Egd1 product, a yeast homolog of human BTF3, may be involved in GAL4 DNA binding
22. The nucleolus and the four ribonucleoproteins of translation
23. Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting
24. The molecular chaperone Ssb from Saccharomyces cerevisiae is a complex of the ribosome-nascent chain complex
25. Signal recognition particle components in the nucleolus
26. Initial characterization of the nascent polypeptide-associated complex in yeast
27. A distinct nuclear import pathway used by ribosomal proteins
28. Identification and functional analysis of the nuclear localization signals of ribosomal protein L25 from Saccharomyces cerevisiae
29. Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
30. Importin/karyopherin protein family members required for mRNA export from the nucleus
31. The yeast Egd2 gene encodes a homologue of the αNAC subunit of the human nascent-polypeptide-associated complex
32. In vivo nuclear transport kinetics in Saccharomyces cerevisiae: A role for heat shock protein 70 during targeting and translocation
33. A nuclear export signal prevents Saccharomyces cerevisiae Hsp70 Ssb1p from stimulating nuclear localization signal-directed nuclear transport
34. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
35. Factors affecting nuclear export of the 60S ribosomal subunit in vivo
36. Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): Role for Srp1p and Sts1p in protein degradation
37. NAC covers ribosome-associated nascent chains, thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center
38. RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3
39. The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane
40. A protein complex required for signal-sequence-specific sorting and translocation
41. Karyopherins and kissing cousins
42. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator