SB-272183, a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist in native tissue

British Journal of Pharmacology

Volumn 133, Issue 6, 2001, Pages 797-806

  Watson, J ^a   Roberts, C ^a   Scott, C ^a   Kendall, I ^a   Collin, L ^a   Day, N C ^b   Harries, M H ^a   Soffin, E ^a   Davies, C H ^a   Randall, A D ^a   Heightman, T ^a   Gaster, L ^a   Wyman, P ^a   Parker, C ^a   Price, G W ^a   Middlemiss, D N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Pharmagene Plc   (United Kingdom)

Author keywords

Guinea pig; Human; Rat; Recombinant cells; SB 272183

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CHLORO 2,3 DIHYDRO 6 (4 METHYLPIPERAZIN 1 YL) 1 [4 (PYRIDIN 4 YL)NAPTH 1 YLAMINOCARBONYL] 1H INDOLE; GUANOSINE TRIPHOSPHATE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SB 272183; SEROTONIN 1A ANTAGONIST; SEROTONIN 1B ANTAGONIST; SEROTONIN 1D ANTAGONIST; SUMATRIPTAN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SEROTONIN RELEASE;

EID: 0034886219     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704133     Document Type: Article

References (38)

1. 5-HT and antidepressants: New views from microdialysis studies
2. A review of central 5-HT receptors and their function
3. 1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphe nucleus: A double labeling in situ hybridisation histochemistry study
4. 1D receptor mRNA and ligand binding sites in guinea-pig brain and trigeminal ganglion:clues for function
5. Nonlinear regression using spreadsheets
6. 50) of an enzymatic reaction
7. 1 receptor subtypes exhibit distinct G protein coupling behaviours in membranes from Sf9 cells
8. 1A receptors in the rat brain
9. Electrophysiological effects of N-(2-(4-(2-Methoxyphenyl)-1-Piperazinyl)Ethyl)-N-(2-Pyrindinyl) Cyclohexane Carboxamide (WAY 100635) on dorsal raphe serotonergic neurons and CA1 hippocampal pyramidal cells in vitro
10. The serotonin hypothesis: Necessary but not sufficient
11. WAY-100635 and GR127935: Effects on 5-hydroxytryptamine-containing neurones
12. Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat
13. 35S]GTPγS autoradiography
14. 1B binding sites
15. 1A receptor antagonist
16. 1A autoreceptor interactions in the rat dorsal raphe nucleus: An in vitro electrophysiological study
17. 2C/2B receptor antagonist with anxioliytic-like properties
18. 1B autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex
19. 1 sites in the rat brain
20. Pindolol augmentation of antidepressant therapy
21. 1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor
22. 5-HT autoreceptors in the regulation of 5-HT release from guinea-pig raphe nucleus and hypothalamus
23. 1D receptors in the rat brain
24. Pindolol and major affective disorders: A three-year follow-up study of 30, 485 patients
25. 1B/D receptor antagonists in dorsal and median raphe innervated brain regions
26. 1B receptor inverse agonist, on in vivo extracellular levels of 5-HT in the freely-moving guinea-pig
27. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: An in vitro fast cyclic voltammetry study
28. Functional characterisation of the 5-HT terminal autoreceptor in the guinea-pig brain cortex
29. 1B receptor agonist:antagonist binding affinity difference as a measure of intrinsic activity
30. 1B receptor antagonist with negative intrinsic activity
31. 1A receptor-activated G proteins in the rat brain
32. GR127935: A potent orally active 5-HT1D receptor antagonist
33. 1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis
34. 1B agonists
35. 1 autoreceptors: Parallel purposes or pointless plurality?
36. 1Dβ receptors
37. 1A receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems
38. 1A receptors