Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease

Lancet

Volumn 347, Issue 9010, 1996, Pages 1212-1217

  Satsangi, Jack ^a,e   Welsh, Ken I ^c   Bunce, Mike ^c   Julier, Cecile ^d   Farrant, J Mark ^a   Bell, John I ^b   Jewell, Derek P ^a  

^a OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQ ANTIGEN; HLA DR ANTIGEN;

ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DISEASE PREDISPOSITION; ENTERITIS; FAMILIAL DISEASE; FEMALE; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; IMMUNOGENETICS; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIBLING; ULCERATIVE COLITIS;

EID: 0030007093     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)90734-5     Document Type: Article

References (29)

1. Satsangi J, Jewell DP, Rosenberg WMC, Bell JI. Genetics of inflammatory bowel disease. Gut 1994; 35: 696-700.
2. Satsangi J, Rosenberg WMC, Jewell DP. The prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease. Eur J Gastroenterol Hepatol 1994; 6: 413-16.
3. Tysk C, Lindberg E, Järnerot G, Flodérus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988; 29: 990-96.
4. Hugot JP, Laurent-Puig P, Gower-Rousseau C, Caillat-Zucman S, Beaugene L, Dupas J. Linkage analyses of chromosome 6 loci, including HLA, in familial aggregations of Crohn's disease. Am J Med Genet 1994; 52: 207-14.
5. Naom IS, Lee JC, Ford D, et al. Genetic predisposition to ulcerative colitis: a detailed study of the HLA region by linkage analysis. Gut 1994; 35: S30.
6. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265: 2037-48.
7. Suarez BK, Rice J, Reich T. The generalised sib pair IBD distribution: its use in the detection of linkage. Ann Hum Genet 1978; 42: 87-94.
8. Bishop DT, Williamson JA. The power of identity-by-state methods for linkage analysis. Am J Hum Genet 1990; 46: 254-65.
9. McConnell RB, Vadheim CM. Inflammatory bowel disease. In: King RA, Rotter JI, Motulsky AO, eds. The genetic basis of common diseases. Oxford: Oxford University Press, 1992: 326-48.
10. Toyoda H, Wang S-J, Yang H, Redford A, Magalong D, Tyan D. Distinct association of HLA class II genes with inflammatory bowel disease. Gastroenterology 1993; 104: 741-48.
11. Wassmuth R, Keller Y, Thompson G, Starck M, Lindhagen T, Holmberg E. HLA DRB1 alleles provide protection against Crohn's disease in Caucasians. Eur J Gastroenterol Hepatol 1994; 6: 405-11.
12. Farmer RG, Whelan G, Fazio VW. Long-term follow-up of patients with Crohn's disease. Gastroenterology 1985; 88: 1818-25.
13. Miller D, Polesky H. A salting-out procedure for extracting DNA from human nucleated cells. Nucl Acid Res 1988; 16: 1215.
14. Bunce M, Taylor CJ, Welsh KI. Rapid HLA-DQB typing by eight PRC amplifications with sequence-specific primers (PCR-SSP). Hum Immunol 1993; 37: 201-06.
15. Olerup O, Zetterquist H. HLA-DR typing by PCR amplifications with sequence-specific primers in 2 hours. An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 225-35.
16. Bunce M, Fanning GC, Welsh KI. Comprehensive serologically equivalent DNA typing for HLA-B by PCR using sequence-specific primers. Tissue Antigens (in press).
17. Risch N. Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 1987; 40: 1-14.
18. Rotter JI, Landaw EM. Measuring the genetic contribution of a single locus to a multi-locus disease. Clin Genet 1984; 26: 529-42.
19. Merrett MN, Bunce M, Mortensen N, Kettlewell MGW, Jewell DP. HLA DRB1(Black star sign) 0103 (HLA-DR-BON) may predict pouchitis in patients who have an ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC). Gastroenterology 1992; 102: A935.
20. Duerr RH, Neigut DA. Molecularly defined HLA-DR2 alleles in ulcerative colitis and an anti-neutrophil cytoplasmic antibody-positive subgroup. Gastroenterology 1995; 108: 423-27.
21. Asakura H, Tsuchiya M, Aiso S, et al. Association of human leucocyte DR2 antigen with Japanese ulcerative colitis. Gastroenterology 1982; 82: 413-18.
22. Reijonen H, Ilonen I, Akerblom HA, Knip M, Dosch H. Childhood diabetes in Finland study group. Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes in Finland. Tissue Antigens 1994; 43: 1-6.
23. Hashimoto M, Kinoshita T, Yamasaki M, Tanaka H, Imanishi T, Ihara H. Gene frequencies and haplotypic associations within the HLA region in 916 unrelated Japanese individuals. Tissue Antigens 1994: 44: 166-73.
24. Roitberg-Tambur A, Friedmann A, Korn S, et al. Serological and molecular analysis of the HLA system in Israeli Jewish patients with oral erosive lichen planus. Tissue Antigens 1994; 43: 219-23.
25. Chapman RW. Aetiology and natural history of primary sclerosing cholangitis: a decade of progress? Gut 1991; 32: 1433-35.
26. Farrant JM, Doherty DG, Donaldson PT, et al. Amino acid substitutions at position 38 of the DRB polypeptide confer susceptibility and protection from primary sclerosing cholangitis. Hepatology 1992; 16: 390-95.
27. Todd JA, Bell JI, McDevitt HO. HLA-DQB gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987; 329: 599-604.
28. Briggs DC, Vaughan RW, Welsh KI, Myers A, Dubois RM, Black CM. Immunogenetic prediction of pulmonary fibrosis in systemic sclerosis. Lancet 1991; 338: 661-62.
29. Wordsworth BP, Lanchbury JSS, Sakkas LI, Welsh KI, Panayi GI, Bell JI. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci 1989; 10053: 10049-153.