Effects of glucocorticoids on pharmacokinetics and pharmacodynamics of midazolam in rats

Life Sciences

Volumn 63, Issue 19, 1998, Pages 1685-1692

  Watanabe, Minoru ^a   Tateishi, Tomonori ^a   Asoh, Masako ^a   Nakura, Hironori ^a   Tanaka, Masami ^a   Kumai, Toshio ^a   Kobayashi, Shinichi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CYP3A; Glucocorticoid; Midazolam; Pharmacokinetic parameter; Sleeping time

Indexed keywords

CORN OIL; CYTOCHROME P450; DEXAMETHASONE; GLUCOCORTICOID; MIDAZOLAM; N DEMETHYLASE; PLACEBO; PREDNISOLONE;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACODYNAMICS; RAT; SLEEP TIME;

ADJUVANTS, ANESTHESIA; ANIMALS; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; GLUCOCORTICOIDS; HALF-LIFE; IMMUNOBLOTTING; MALE; MICROSOMES, LIVER; MIDAZOLAM; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A; ZEA MAYS;

EID: 0032476161     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(98)00440-8     Document Type: Article

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