Application of the gene search system to screen for longevity genes in Drosophila

Biogerontology

Volumn 2, Issue 3, 2001, Pages 209-217

  Seong, Ki Hyeon ^a   Ogashiwa, Takumi ^a   Matsuo, Takashi ^a   Fuyama, Yoshiaki ^a   Aigaki, Toshiro ^a,b  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Drosophila melanogaster; Gain of function screen; Gene search system; Longevity; Paraquat resistance

Indexed keywords

GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE; GENE PRODUCT; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE 2; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 26; HEAT SHOCK PROTEIN 70; NLA PROTEIN; OXIDOREDUCTASE; POSH PROTEIN; THIOREDOXIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

AGING; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DEVELOPMENTAL BIOLOGY; DNA VECTOR; DROSOPHILA; EXPRESSED SEQUENCE TAG; FEMALE; GENE EXPRESSION; GENE INSERTION; GENETIC SCREENING; GENETICS; LONGEVITY; MALE; MOLECULAR GENETICS; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROMOTER REGION; STRESS; TRANSGENE;

ANIMALS; DROSOPHILA; FEMALE; GENETIC SCREENING; LONGEVITY; MALE; MODELS, GENETIC; MUTAGENESIS; OXIDATIVE STRESS;

EID: 0034849336     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011517325711     Document Type: Article

References (33)

1. The genome sequence of Drosophila melanogaster
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op 18
4. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
5. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly
6. Isolation of a Drosophila gene encoding glutathione S-transferase
7. Klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron
8. Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress
9. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
10. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
11. Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions
12. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
13. A C. elegans mutant that lives twice as long as wild type
14. Expression patterns of two new members of the Semaphorin family in Drosophila suggest early functions during embryogenesis
15. Aging and resistance to oxidative damage in Caenorhabditis elegans
16. Extended life-span and stress resistance in the Drosophila mutant methuselah
17. hsp23 and hsp26 exhibit distinct spatial and temporal patterns of constitutive expression in Drosophila adults
18. Inhibition of heat shock protein synthesis by heat-inducible antisense RNA
19. shc adaptor protein controls oxidative stress response and life span in mammals
20. Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton
21. On the specificity of antisense RNA to arrest in vitro translation of mRNA coding for Drosophila hsp 23
22. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
23. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
24. 2 upon thioredoxin-enriched lens epithelial cells
25. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
26. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage
27. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways
28. In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: Characterization of a multi-step anterior localization pathway
29. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster
30. Aging mechanisms in fruit files
31. Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster
32. Isolating aging mutants: A novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans
33. The transmembrane Semaphorin Sema I is required in Drosophila for embryonic motor and CNS axon guidance