Isolating aging mutants: A novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans

Mechanisms of Ageing and Development

Volumn 113, Issue 2, 2000, Pages 101-116

  Yang, Yulong ^a   Wilson, David L ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b University of Miami   (United States)

Author keywords

Aging; C. elegans; Heat shock; Life span; Longevity; Mutant

Indexed keywords

AGING; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; FEEDING BEHAVIOR; FERTILITY; HEAT SHOCK; HEAT STRESS; HERMAPHRODITISM; LIFESPAN; LOCOMOTION; LONGEVITY; MALE; MATING; MUTANT; NEMATODE; NONHUMAN; PRIORITY JOURNAL; TECHNIQUE;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; FEEDING BEHAVIOR; FEMALE; FERTILITY; HEAT; LOCOMOTION; LONGEVITY; MALE; MUTATION; SEXUAL BEHAVIOR, ANIMAL;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 0033979686     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(99)00100-1     Document Type: Article

References (28)

1. Austad S.N. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana). J. Zool. 229:1993;695-708.
2. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 77:1974;71-94.
3. Fisher L.D., Van Belle G. Biostatistics: A Methodology for the Health Sciences. 1993;A Wiley-Interscience Publication, Wiley, New York.
4. Friedman D.B., Johnson T.E. Three mutants that extend both mean and maximum life span of the nematode Caenorhabditis elegans, define the age-1 gene. J. Gerontol. 43(4):1988;B102-109.
5. Friedman D.B., Johnson T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 118:1988;75-86.
6. Glantz S.A. Primer of Biostatistics. 1992;McGraw-Hill, New York.
7. Johnson T.E., Wood W.B. Genetic analysis of life span in Caenorhabditis elegans. Proc. Natl. Acad. Sci. 79:1982;6603-6607.
8. Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans that lives twice as long as wild-type. Nature. 366:1993;461-464.
9. Kenyon C Environmental factors and gene activities that influence life span. Riddle D.L., Blumenthal T., Meyer B.J., Priess J.R. C. elegans II. 1997;791-813 Cold Spring Harbor Laboratory, New York.
10. Kimble J., Ward S. Germ-line development and fertilization. Wood W.B. et al. The Nematode Caenorhabditis elegans. 1998;191-213 Cold Spring Harbor Laboratory, New York.
11. Kirkwood T.B. Comparative evolutionary aspects of longevity. Finch C.E., Schneider E.L. Handbook of the Biology of Aging. 2nd ed:1985;27-45 Van Nostrand, New York.
12. Kirkwood T.B. The disposable soma theory of ageing. Harrison D.E. Genetic Effects on Aging II. 1990;9-19 Telford Press, New Jersey.
13. Klass M.R. Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech. Aging. Dev. 6:1977;413-429.
14. Klass M.R. A method for isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech. Aging. Dev. 22:1983;279-286.
15. Lakowski B., Hekimi S Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272:1996;1010-1013.
16. Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 90:1993;8905-8909.
17. Lithgow G.J., White T.M., Hinerfeld D.A., Johnson T.E. Thermotolerance of a long lived mutant of Caenorhabditis elegans. J. Gerontol. 49(6):1994;B270-B276.
18. Lithgow G.J., White T.M., Melov S., Johnson T.E. Thermotolerance and extended life span conferred by single-gene mutations and induced by thermal stress. Proc. Natl. Acad. Sci. USA. 92:1995;7540-7544.
19. Miller R.A. Kleemeier award lecture: are there genes for aging? J. Gerontol. 54A(7):1999;B297-B307.
20. Russell R.L., Jacobson L.A. Some aspect of aging can be studied easily in nematodes. Finch C.E., Schneider E.L. Handbook of the Biology of Aging. 1985;128-145 Van Nostrand Reinhold, New York.
21. Vanfleteren J.R. Oxidative stress and aging in Caenorhabditis elegans. Biochem. J. 292:1993;605-608.
22. Van Voorhies W.A. Production of sperm reduces nematode life span. Nature. 360:1992;456-458.
23. White J. Anatomy. Wood W.B. et al. The Nematode Caenorhabditis elegans. 1988;81-122 Cold Spring Harbor Laboratory, New York.
24. Wilson D.L. The programmed theory of aging. Rockstein M. Theoretical Aspects of Aging. 1974;11-21 Academic Press, New York.
25. Wong A., Boutis P., Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics. 139:1995;1247-1258.
26. Wood W.B. Introduction to C. elegans biology. Wood W.B. et al. The Nematode Caenorhabditis elegans. 1988;1-16 Cold Spring Harbor Laboratory, New York.
27. Yang Y., Wilson D.L. Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. J. Gerontol. 54A(4):1999;B137-B142.
28. Zuckerman B.M., Himmelhoch S. Nematodes as models to study aging. Zuckerman B.M. Nematodes as Biological Models. 2:1980;3-28 Academic Press, New York.