Psoriatic arthritis: Clinical aspects, genetics, and the role of T cells

Current Opinion in Rheumatology

Volumn 13, Issue 4, 2001, Pages 273-279

  Höhler, Thomas ^a   Märker Hermann, Elisabeth ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; HLA B27 ANTIGEN; HLA B57 ANTIGEN; RECOMBINANT LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

CHROMOSOME 17Q; CHROMOSOME 19P; CHROMOSOME 1Q; CHROMOSOME 6P; GENE LOCUS; GENETIC ANALYSIS; GENETIC CODE; HUMAN; IMMUNOPATHOGENESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; REVIEW; T LYMPHOCYTE;

ARTHRITIS, PSORIATIC; HUMANS; T-LYMPHOCYTES;

EID: 0034841506     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200107000-00005     Document Type: Review

References (64)

1. The genetics of psoriasis: A complex disorder of the skin and immune system
2. Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors
3. Spondyloarthropathies in sub-Saharan Africa
4. Psoriatic arthritis and human immunodeficiency virus infection in Zambia
5. Baseline relationships between psoriasis and psoriatic arthritis: Analysis of 221 patients with active psoriatic arthritis
6. Psoriatic arthritis: Interrelationships between skin and joint manifestations related to onset, course and distribution
7. Subsets in psoriatic arthritis formed by cluster analysis
8. Spinal hyperostosis-a rare skeletal manifestation of psoriasis vulgaris
9. Bilateral upper limb lymphoedema associated with psoriatic arthritis: A case report and review of the literature
10. Bone mineral density in patients with psoriatic arthritis
11. Serum osteocalcin levels in patients with psoriatic arthritis: An extended report
12. Genetics of psoriasis
13. Immunogenetic profile of patients with psoriatic arthritis varies according to the age at onset of psoriasis
14. Genetic counseling in psoriasis: Empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands
15. Evidence that a locus for familial psoriasis maps to chromosome 4q
16. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q
17. Age at onset and different types of psoriasis
18. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
19. Linkage disequilibrium analysis of familial psoriasis: Identification of multiple disease-associated MHC haplotypes
20. A non-HLA gene within the MHC in psoriasis
21. Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis
22. Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris
23. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele
24. The OTF3 gene polymerphism confers susceptibility to psoriasis independent of the association of HLA-Cw*0602
25. Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene
26. Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C
27. Genetics of psoriasis: Paternal inheritance and a locus on chromosome 6p
28. Tumor necrosis factor-alpha gene polymorphism in psoriasis
29. A TNF-alpha promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis
30. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism
31. Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomised trial
32. A genome-wide search for genes predisposing to familial psoriasis by using a stratification approach
33. Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13
34. The variable incidence of psoriasis in sub-Saharan Africa
35. Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan
36. Searching for psoriasis susceptibility genes in Italy: Genome scan and evidence for a new locus on chromosome 1
37. Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
38. A genome-wide screen for susceptibitity loci in ankylosing spondylitis
39. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16
40. American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 1 2
41. Increased occurrence of psoriasis in patients with Crohn's disease and their relatives
42. Vitamin D receptor polymorphism is associated with psoriasis
43. Comparison of clinical and immunogenetic features in familial versus sporadic psoriatic arthritis
44. Genetic studies of psoriatic arthritis: Dissecting joints and skin
45. TAP-polymorphisms in juvenile onset psoriasis and psoriatic arthritis
46. LMP polymorphisms do not influence disease expression in psoriatic arthritis
47. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis
48. Genetic locus for psoriasis identified
49. Excessive paternal transmission in psoriatic arthritis
50. T-cell studies in the spondyloarthropathies
51. Predominance of CD8+ T lymphocytes in psoriatic arthritis
52. Localized monocyte chemotactic protein-1 production correlates with T cell infiltration of synovium in patients with psoriatic arthritis
53. Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven
54. Clonal characteristics of T cell infiltrates in skin and synovium of patients with psoriatic arthritis
55. CD4+ and CD8+ clonal T cell expansions indicate a role of antigens in ankylosing spondylitis; a study in HLA-B27+ monozygotic twins
56. Identical T-cell expansions in the colon mucosa and the synovium of a patient with enterogenic spondyloarthropathy
57. Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: Towards a reassessment of the physiopathologic significance of T cell clonal expansions found in autoimmune inflammatory processes
58. Superantigens, autoantigens, and pathogenic T cells in psoriasis
59. Psoriasis
60. Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins
61. There is no disease-specific role for streptococci-responsive synovial T lymphocytes in the pathogenesis of psoriatic arthritis
62. Psoriatic arthritis
63. Treatment of psoriatic arthritis with antitumor necrosis factor-alpha antibody clears skin lesions of psoriasis resistant to treatment with methotrexate
64. Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: Histologic findings in eight patients from an open-label pilot study