Major carbohydrate antigen of Echinococcus multilocularis induces an immunoglobulin G response independent of αβ+ CD4+ T cells

Infection and Immunity

Volumn 69, Issue 10, 2001, Pages 6074-6083

  Dai, W J ^a   Hemphill, A ^a   Waldvogel, A ^a   Ingold, K ^a   Deplazes, P ^a   Mossmann, H ^a   Gottstein, B ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; INTERLEUKIN 2; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CESTODE; CONTROLLED STUDY; CYTOKINE RELEASE; ECHINOCOCCOSIS; ECHINOCOCCUS MULTILOCULARIS; FEMALE; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MEMBRANE COMPONENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, HELMINTH; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGENS, CD40; ANTIGENS, HELMINTH; CARBOHYDRATES; CD4-POSITIVE T-LYMPHOCYTES; CELL POLARITY; ECHINOCOCCUS; FEMALE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, NUDE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0034826591     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.10.6074-6083.2001     Document Type: Article

References (50)

1. Functional diversity of helper T lymphocytes
2. Secondary alveolar echinococcosis in lymphotoxin-alpha and tumour necrosis factor-alpha deficient mice: Exacerbation of Echinococcus multilocularis larval growth is associated with cellular changes in the periparasitic granuloma
3. Effect of chemotherapy on the larval mass and the long-term course of alveolar echinococcosis
4. The role of germinal centers for antiviral B cell responses
5. Immune responses in the absence of costimulation: Viruses know the trick
6. Neutralizing antiviral B cell responses
7. Antibody response in CD4-depleted mice after immunization or during early infection with Echinococcus granulosus
8. Cellular immunity in experimental Echinococcus multilocularis infection. II. Sequential and comparative phenotypic study of the periparasitic mononuclear cells in resistant and sensitive mice
9. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells
10. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice
11. Nitric oxide-mediated immunosuppression following murine Echinococcus multilocularis infection
12. A monoclonal antibody against Echinococcus multilocularis Em2 antigen
13. Intraperitoneal murine alveolar hydatidosis: Relationship between the size of the larval cyst mass, immigrant inflammatory cells, splenomegaly and thymus involution
14. Complement evasion by Echinococcus granulosus: Sequestration of host factor H in the hydatid cyst wall
15. Cytokine and chemokine secretion by human peripheral blood cells in response to viable Echinococcus multilocularis metacestode vesicles
16. Enhancement of T cell-independent immune responses in vivo by CD40 antibodies
17. Characterization of T-cell immune response to Echinococcus multilocularis-infected C57BL/6J mice
18. T-independent activation of B cells by vesicular stomatitis virus: No evidence for the need of a second signal
19. T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses
20. Comparative analysis of full-length antigen II/3 from Echinococcus multilocularis and E. granulosus
21. Regulation and biological function of helminth-induced cytokine responses
22. Immune regulation by CD40 and its ligand GP39
23. Immunity to rotavirus in T cell deficient mice
24. Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile in humans. I. Comparison of patients with progressive and abortive lesions
25. Echinococcus multilocularis: Immunological study on the "Em2-positive" laminated layer during in vitro and in vivo post-oncospheral and larval development
26. Protective immune mechanisms against the metacestode of Echinococcus multilocularis
27. Immunopathology of echinococcosis
28. Echinococcus multilocularis: Parasite-specific humoral and cellular immune response subsets in mouse strains susceptible (AKR, C57B1/6J) or 'resistant' (C57B1/10) to secondary alveolar echinococcosis
29. One dimensional polyacrylamide gel electrophoresis
30. Clinical efficacy of and switch from T helper 2 to T helper 1 cytokine profile after interferon alpha2a monotherapy for human echinococcosis
31. Immunology and morphology studies on the proliferation of in vitro cultivated Echinococcus multilocularis metacestodes
32. High molecular mass glycans are major structural elements associated with the laminated layer of in vitro cultivated Echinococcus multilocularis metacestodes
33. Identification of a laminated layer-associated protein in Echinococcus multilocularis metacestodes
34. Improved diagnosis of primary Toxoplasma gondii infection in early pregnancy by determination of antitoxoplasma immunoglobulin G avidity
35. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
36. The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells
37. Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection
38. Carbohydrates on the surface of Echinococcus granulosus protoscoleces are immunodominant in mice
39. T cell-independent antigens type 2
40. T cell independent antigens
41. The antibody response to fungal melanin in mice
42. Spontaneous death of Echinococcus multilocularis: Cases diagnosed serologically (by Em2 ELISA) and clinical significance
43. Antibody response of Echinococcus granulosus infected mice: Protoscolex specific response during infection is associated with decreasing specific IgG1/IgG3 ratio as well as decreasing avidity
44. A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens
45. Interleukin-5 is the predominant cytokine produced by peripheral blood mononuclear cells in alveolar echinococcosis
46. T cell-independent antibody-mediated clearance of polyomavirus in T cell-deficient mice
47. T-cell-independent antiviral antibody responses
48. IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
49. Cryptococcus neoformans differently regulates B7-1 (CD80) and B7-2 (CD86) expression on human monocytes
50. Humoral and cellular immunity in patients with hepatic alveolar echinococcosis. A 2 year follow-up with and without Flabendazole treatment