Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 521-526

  Paillart, Christophe ^a   Carlier, Edmond ^a   Guedin, Denis ^b   Dargent, Bénédicte ^a   Couraud, François ^a,c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Rossel Uclaf   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BATRACHOTOXININ A 20ALPHA BENZOATE; DAIDZEIN; ERBSTATIN; GENISTEIN; LAVENDUSTIN A; NEUROTOXIN; PROTEIN TYROSINE KINASE INHIBITOR; SAXITOXIN; SODIUM CHANNEL; TYRPHOSTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; DOSE RESPONSE; DRUG INHIBITION; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SODIUM CURRENT; SODIUM TRANSPORT; SYNAPTOSOME;

EID: 0030933913     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. AKIYAMA T. AND OGAWARA H.: Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Methods Enzymol. 201: 362-370, 1991.
2. AKIYAMA T., ISHIDA J., NAKAGAWA S., OGAWARA H., WATANABE S., ITOH N., SHIBUYA M. AND FUKAMI Y.: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262: 5592-5595, 1987.
3. BAKER L. P. AND PENG H. B.: Tyrosine phosphorylation and acetylcholine receptor cluster formation in cultured Xenopus muscle cells. J. Cell Biol. 120: 185-195, 1993.
4. BEZANILLA F. AND ARMSTRONG C. M.: Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol. 70: 549-566, 1977.
5. CATTERALL W. A.: Neurotoxins that act on voltage sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 20: 15-43, 1980.
6. + channels: Local anesthetics, antiarrythmics and anticonvulsants. Trends Pharmacol. Sci. 8: 57-65, 1987.
7. COURAUD F., MARTIN-MOUTOT N., KOULAKOFF A. AND BERWALD-NETTER Y.: Neurotoxin-sensitive sodium channels in neurons developing in vivo and in vitro. J. Neurosci. 6: 192-198, 1986.
8. DARGENT B., PAILLART C., CARLIER E., ALCARAZ G., MARTIN -EAUCLAIRE M. F. AND COURAUD F.: Sodium channel internalization in developing neurons. Neuron 13: 683-690, 1994.
9. 3H]glutamate release, Neurosci. Lett. 155: 87-91, 1993.
10. HUANG J., NASR M., KIM Y. AND MATTHEWS U. R.: Genistein inhibits protein histidine kinase. J. Biol. Chem. 267: 15511-15515, 1992.
11. + channel subunits and scorpion toxin binding sites. J. Biol Chem. 263: 1542-1548, 1988.
12. LI M., WEST J. W., NUMANN R., MURPHY B. J., SCHEUER T. AND CATTERALL W. A.: Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase. Science 61: 1439-1442, 1993.
13. LOMBET A., MOURRE C. AND LAZDUNSKI M.: Interaction of insecticides of the pyrethroid family with specific binding sites on the voltage-dependent sodium channel from mammalian brain. Brain Res. 459: 44-53, 1988.
14. NUMANN R., CATTERALL W. A. AND SCHEUER T.: Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science 254: 115-118, 1991.
15. O'DELL T. J., KANDEL E. R. AND GRANT S. G.: Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353: 558-560, 1991.
16. PAZIN M. J. AND WILLIAMS L. T.: Triggering signaling cascades by receptor tyrosine kinases. Trends Biochem. Sci. 17: 374-378, 1992.
17. POLI M. A., MENDE T. J. AND BADEN D. G.: Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes. Mol. Pharmacol. 30: 129-135, 1986.
18. 3H]batrachotoxinin A 20-α-benzoate to sodium channels by local anesthetics. Mol. Pharmacol. 25: 219-227, 1984.
19. PURÉ E. AND TARDELLI L.: Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor in B lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 89: 114-117, 1992.
20. + channels, expressed in a mammalian cell line, by local anesthetics, antiarrythmics and anticonvulsant drugs. Mol. Pharmacol. 40: 756-765, 1991.
21. SALTIEL A. R. AND OHMICHI M.: Pleiotropic signaling from receptor tyrosine kinases. Curr. Opin. Neurobiol. 3: 352-359, 1993.
22. TRAINER V. L., MOREAU E., GUEDIN D., BADEN D. G. AND CATTERALL W. A.: Neurotoxin binding and allosteric modulation at receptor sites 2 and 5 on purified and reconstituted rat brain sodium channels. J. Biol. Chem. 268: 17114-17119, 1993.
23. WANG Y. T. AND SALTER M. W.: Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369: 233-235, 1994.