Sustained biochemical and histologic remission of primary biliary cirrhosis in response to medical treatment

Annals of Internal Medicine

Volumn 126, Issue 9, 1997, Pages 682-688

  Kaplan, Marshall M ^a   DeLellis, Ronald A ^a   Wolfe, Hubert J ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG EFFECT; DRUG RESPONSE; FEMALE; HUMAN; LIVER BIOPSY; ORAL DRUG ADMINISTRATION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; REMISSION;

EID: 0030997576     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-126-9-199705010-00002     Document Type: Article

References (20)

1. Kaplan MM. Primary biliary cirrhosis. N Engl J Med. 1996;335:1570-8.
2. James SP, Hoofnagle JH, Strober W, Jones EA. NIH conference: Primary biliary cirrhosis: a model autoimmune disease. Ann Intern Med. 1983;99: 500-2.
3. Poupon RE, Poupon R, Balkau B. Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group. N Engl J Med. 1994; 330:1342-7.
4. Kaplan MM, Alling DW, Zimmerman HJ, Wolfe HJ, Sepersky RA, Hirsch GS, et al. A prospective trial of colchicine for primary biliary cirrhosis. N Engl J Med. 1986;5:1448-54.
5. Vierling JM. Primary biliary cirrhosis. In: Zakim D, Boyer TD, eds. Hepatology: A Textbook of Liver Disease. 2d ed. Philadelphia: WB Saunders, 1990:1181.
6. Sherlock S. Therapeutic trials in primary biliary cirrhosis. QJM. 1994;87:701-3.
7. Balasubramaniam K, Grambsch PM, Wiesner RH, Lindor KD, Dickson ER. Diminished survival in asymptomatic primary biliary cirrhosis. A prospective study. Gastroenterology 1990;98:1567-71.
8. Kaplan MM, Knox TA. Treatment of primary biliary cirrhosis with low-dose weekly methotrexate. Gastroenterology 1991;101:1332-8.
9. Scheuer PJ. Primary biliary cirrhosis. Proc R Soc Med. 1967;60:1257-60.
10. Kaplan MM, Gandolfo JV, Quaroni EG. An enzyme-linked immunosorbant assay (ELISA) for detecting antimitochondrial antibody. Hepatology 1984;4: 727-30.
11. Lindor KD, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Murtaugh PA, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology. 1994;106:1284-90.
12. Heathcote EJ, Cauch-Dudek K, Walker V, Bailey RJ, Blendis LM, Ghent CN, et al. The Canadian Multicenter Double-blind Randomized Controlled Trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology. 1994;19: 1149-56.
13. Combes B, Carithers RL, Maddrey WC, Munoz SJ, McDonald MF, Garcia-Tsao G, et al. A randomized, double-blind, placebo controlled trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis [Abstract]. Hepatology. 1993;18:175A.
14. Jorgenson RA, Dickson ER, Hofmann AF, Rossi SS, Lindor KD. Characterization of patients with a complete biochemical response to ursodeoxycholic acid. Gut. 1995;36:935-8.
15. Lombard M, Portmann BP, Neuberger J, Williams R, Tygstrup N, Ranek L, et al. Cyclosporin A treatment in primary biliary cirrhosis: results of a long-term placebo controlled trial. Gastroenterology. 1993;104:519-26.
16. Sharma A, Provenzale D, McKusick A, Kaplan MM. Interstitial pneumonitis after low-dose methotrexate therapy in primary biliary cirrhosis. Gastroenterology. 1994;107:266-70.
17. Soloway RD, Summerskill WH, Baggenstoss AH, Geall MG, Gitnick GL, Elveback LR, et al. Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology. 1972;63:820-3.
18. Lindor KD, Jorgenson RA, Anderson ML, Gores GJ, Baldus WP, Dickson ER. The combination of ursodeoxycholic acid (UDCA) and methotrexate (MTX) for patients with primary biliary cirrhosis (PBC): the results of a pilot study [Abstract]. Hepatology. 1994;20:202A.
19. Buscher HP, Zietzschmann Y, Gerok W. Positive responses to methotrexate and ursodeoxycholic acid in patients with primary biliary cirrhosis responding insufficiently to ursodeoxycholic acid alone. J Hepatol. 1993;18:9-14.
20. Bergasa NV, Jones A, Kleiner DE, Rabin L, Park Y, Wells MC, et al. Pilot study of low dose oral methotrexate treatment for primary biliary cirrhosis. Am J Gastroenterol. 1996;91:295-9.