Induction of apoptosis in rat hepatic stellate cells by disruption of integrin-mediated cell adhesion

Journal of Laboratory and Clinical Medicine

Volumn 134, Issue 1, 1999, Pages 83-89

  Iwamoto, Hiroaki ^a   Sakai, Hironori ^b   Tada, Seiya ^b   Nakamuta, Makoto ^b   Nawata, Hajime ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033166608     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(99)90057-4     Document Type: Article

References (33)

1. 1. Hynes RO. Integrins: versatility, modulation and signaling in cell adhesion. Cell 1992;69:11-25.
2. 2. Juliano RL, Haskill S. Signal transduction from the extracellular matrix. J Cell Biol 1993;120:577-85.
3. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994;79:1157-64.
4. 4. Blau H, Baltimore D. Differentiation requires continuous regulation. J Cell Biol 1991;112:781-3.
5. 5. Meredith JE, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993;4:953-61.
6. 6. Boudreau N, Sympson CJ, Werb Z, Bissel MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 1995;267:891-3.
7. 7. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-62.
8. 8. Steller H. Mechanisms and genes of cellular suicide. Science 1995;267:1445-9.
9. 9. Raff MC, Baress BA, Burne JF, Coles AS, Ishizaki Y, Jacobson MD. Programmed cell death and the control of cell survival: lesson from the nervous system. Science 1993;262:695-700.
10. 10. Re F, Zanetti A, Sironi M, Polentarutti N, Lanfrancone L, Dejana E, et al. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 1994;127:537-46.
11. 11. Bates RC, Buret A, Van Helden DF, Horton MA, Burns GF. Apoptosis induced by inhibition of intercellular contact. J Cell Biol 1994;125:403-15.
12. 12. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-26.
13. 13. Ruoslahtti E, Reed JC. Anchorage dependence, integrins, and apoptosis. Cell 1994;77:477-8.
14. 14. Friedman SL. The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. N Engl J Med 1993;328:1828-35.
15. 15. Pinzani M. Novel insight into the biology and physiology of the Ito cell. Pharmacol Ther 1995;66:387-412.
16. FAK in cultured fibroblasts results in apoptosis. J Cell Biol 1996;135:1383-90.
17. 17. Carloni V, Romanneli RG, Pinzani M, Laffi G, Gentilini P. Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells. Gastroenterology 1996;110:1127-36.
18. 1 integrin in wound contraction. J Biol Chem 1997;272:30911-7.
19. 19. De Leeuw AM, McCarthy SP, Geerts A, Knook DL. Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 1984;4:392-403.
20. waf/cipl. Genes Dev 1994;8:2817-30.
21. 21. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, Raft MC. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 1993;361:365-9.
22. 22. Laemmli UK. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
23. 23. Miyashita T, Krajewski S, Krajewski M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799-1805.
24. 24. Miyashita TS, Harigari M, Hanada M, Reed JC. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 1994;54:3131-5.
25. 25. Miyashita TS, Reed JC. Tumor suppressor p53 is a direct transcriptionaf activator of the human bax gene. Cell 1995;80:293-9.
26. 26. Oltvai ZN, Millman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993;74:609-19.
27. 27. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and hetcrodimerization with bax. Nature 1994;369:321-3.
28. 28. Pierschbacher MD, Ruoslahti E. Influence of stereochemistry of the sequence arg-gly-asp-xaa on binding specificity in cell adhesion. J Biol Chem 1987;262:17294-8.
29. 1, integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci 1995;92:6161-5.
30. 30. Symonds H, Krali L, Remington L, Saenz-Robles M, Lowe S, Jacks T, et al. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 1994;78:703-11.
31. 31. Illic D, Almeida EA, Schlaepfer DD, Dazin P, Aizawa S, Damsky CH. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol 1998;43:547-60.
32. 32. Iwamoto H, Sakai H, Nawata H. Inhibition of integrin signaling with arg-gly-asp motifs in rat hepatic stellate cells. J Hepatol 1998;29:752-9.
33. 33. Bruck R, Hershkoviz R, Lider O, Aeed H, Zaidel L, Matas Z, et al. Inhibition of experimentally-induced liver cirrhosis in rats by a nonpeptidic mimetic of the extracellular matrix-associated arg-gly-asp epitope. J Hepatol 1996;24:731-8.