Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat

British Journal of Nutrition

Volumn 81, Issue 3, 1999, Pages 235-242

  Jewell, Christopher ^a   O'Brien, Nora M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Carotenoids; Cytochrome P450; Enzyme induction

Indexed keywords

3 METHYLCHOLANTHRENE; ASTAXANTHIN; BETA CAROTENE; CANTHAXANTHIN; CAROTENOID; CYTOCHROME P450; ETHOXYRESORUFIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LYCOPENE; PENTOXYRESORUFIN; RESORUFIN DERIVATIVE; XANTHOPHYLL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; ENZYME INDUCTION; KIDNEY; LIVER; LUNG; MALE; NONHUMAN; RAT; SMALL INTESTINE; STATISTICAL ANALYSIS; TISSUE LEVEL; XENOBIOTIC METABOLISM;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0032961177     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0007114599000434     Document Type: Article

References (34)

1. Alam BS, Alam SQ, Bendich A & Shapiro SS (1989) Effect of dietary lipids on hepatic and plasma beta-carotene and vitamin A levels in rats fed beta-carotene. Nutrition and Cancer 12, 57-60.
2. Alam BS, Brown LR & Alam SQ (1990) Influence of dietary fats and vitamin E on plasma and hepatic vitamin A and beta-carotene levels in rats fed excess beta-carotene. Nutrition and Cancer 14, 111-116.
3. American Institute of Nutrition (1977) Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. American Journal of Nutrition 107, 1340-1348.
4. Ash M & Ash I (1995) Handbook of Food Additives. Aldershot: Gower Publishing Limited.
5. Astorg P (1988) Testing diets low in alpha-linolenic acid in growing, gestating and lactating female rats. Nutrition Reports International 38, 823-831.
6. Astorg P, Gradelet S, Leclerc J, Canivenc MC & Siess MH (1994) Effects of β-carotene and canthaxanthin on liver xenobiotic-metabolizing enzymes in the rat. Food and Chemical Toxicology 32, 735-742.
7. Astorg P, Gradelet S, Leclerc J & Siess MH (1997) Effects of provitamin A or non-provitamin A carotenoids on liver xenobiotic-metabolizing enzymes in mice. Nutrition and Cancer 27, 245-249.
8. Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE & Comstock GW (1993) Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiology, Biomarkers and Prevention 2, 335-339.
9. Blakely SR, Grundel E, Jenkins HY & Mitchell GV (1990) Alterations in β-carotene and vitamin E status in rats fed β-carotene and excess vitamin A. Nutrition Research 10, 1035-1044.
10. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T & Mayer RT (1985) Ethoxy-pentoxy-and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochrome P450. Biochemical Pharmacology 34, 3337-3345.
11. Cotgreave JA & Moldéus P (1986) Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems. Journal of Biochemical and Biophysical Methods 13, 231-246.
12. Craft NE & Wise SA (1992) Optimisation of an isocratic high performance liquid chromatographic separation of carotenoids. Journal of Chromatography 589, 171-176.
13. Edes TE, Thornton W Jr & Shah J (1989) β-Carotene and aryl hydrocarbon hydroxylase in the rat: an effect of β-carotene independent of vitamin A activity. Journal of Nutrition 119, 769-799.
14. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA & Willett WC (1995) Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 87, 1767-1776.
15. Gradelet S, Astorg P, Le Bon AM, Berges R & Suschetet M (1997) Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers. Cancer Letters 114, 221-223.
16. Gradelet S, Astorg P, Leclerc J, Chevalier J, Vernevaut MF & Siess MH (1996a) Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic metabolizing enzymes in the rat. Xenobiotica 26, 49-63.
17. Gradelet S, Leclerc J, Siess MH & Astorg P (1996b) β-Apo-8′-carotenal, but not β-carotene, is a strong inducer of liver cytochromes P450 1A1 and 1A2 in rat. Xenobiotica 26, 909-919.
18. Habig WH, Pabst MJ & Jakoby WB (1974) Glutathione S-transferases. Journal of Biological Chemistry 249, 7130-7139.
19. Heinonen OP & Albanes D (1994) Alpha-tocopherol, beta-carotene prevention study group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 330, 1029-1035.
20. Hughes DA, Wright AJ, Finglas PM, Peerless AC, Bailey AL, Astley SB, Pinder AC & Southon S (1997) The effect of beta-carotene supplementation on the immune function of blood monocytes from healthy male nonsmokers. Journal of Laboratory and Clinical Medicine 129, 309-317.
21. Krinsky NI (1991) Effects of carotenoids in cellular and animal systems. American Journal of Clinical Nutrition 53, 238-246.
22. LaChance P (1988) Dietary intake of carotenes and the carotene gap. Clinical Nutrition 7, 118-122.
23. Manorama R, Chinnasamy N & Rukmini C (1993) Effect of red palm oil on some hepatic drug metabolizing enzymes in rats. Food and Chemical Toxicology 31, 583-588.
24. 14C]lycopene in rats and monkeys. Journal of Nutrition 120, 1205-1213.
25. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH, Barnhart S, Cherniack MG, Brodkin CA & Hammar S (1996) Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. Journal of the National Cancer Institute 88, 1550-1559.
26. Rock CL, Jacob RA & Bowen PE (1996) Update on the biological characteristics of the antioxidant micronutrients: vitamin C, vitamin E and the carotenoids. Journal of the American Dietetic Association 96, 693-702.
27. Santos MS, Meydani SN, Leka L, Wu D, Fotouhi N, Meydani M, Hennekens CH & Gaziano JM (1996) Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. American Journal of Clinical Nutrition 64, 772-777.
28. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto FK, Goeke NM, Olsen BJ & Klenk DC (1985) Measurement of protein using bicinchoninic acid. Analytical Chemistry 150, 76-85.
29. Stahl W & Sies H (1996) Lycopene: a biologically important carotenoid for humans? Archives of Biochemistry and Biophysics 336, 1-9.
30. Steinmetz KA & Potter JD (1996) Vegetables, fruit and cancer prevention: a review. Journal of the American Dietetic Association 96, 1027-1039.
31. Toma S, Losardo PL, Vincent M & Palumbo R (1995) Effectiveness of beta-carotene in cancer chemoprevention. European Journal of Cancer Prevention 4, 213-224.
32. Van Poppel G, Poulsen H, Loft S & Verhagen H (1995) Influence of beta-carotene on oxidative DNA damage in male smokers. Journal of the National Cancer Institute 87, 310-311.
33. Zhang LX, Cooney RV & Bertram JS (1992) Carotenoids up-regulate connexin-43 gene expression independent of their provitamin A or antioxidant properties. Cancer Research 52, 5707-5712.
34. Ziegler RG, Colavito EA, Hartge P, McAdams MJ, Schoenberg JB, Mason TJ & Fraumeni JF (1996) Importance of alpha-carotene, beta-carotene and other phytochemicals in the etiology of lung cancer. Journal of the National Cancer Institute 88, 612-615.