Development of basal and induced testosterone hydroxylase activity in the chicken embryo in ovo

British Journal of Pharmacology

Volumn 122, Issue 2, 1997, Pages 344-350

  Paolini, Moreno ^a   Pozzetti, Laura ^a   Sapone, Andrea ^a,b   Biagi, Gian Luigi ^a   Cantelli Forti, Giorgio ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Chicken embryo liver; Cytochrome P450; Phenobarbitone induction; Testosterone hydroxylase

Indexed keywords

ANDROSTENEDIONE; CYTOCHROME P450; OXYGENASE; PHENOBARBITAL; POLYCLONAL ANTIBODY; TESTOSTERONE; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; HATCHING; LIVER; METABOLISM; NONHUMAN; ONTOGENY; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANIMALS, NEWBORN; ARYL HYDROCARBON HYDROXYLASES; CHICK EMBRYO; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; LIVER; MICROSOMES, LIVER; PHENOBARBITAL; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0030772781     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701352     Document Type: Article

References (53)

1. BAILEY, Y.L. (1967) Techniques in Protein Chemistry, pp. 340-341. Amsterdam: Elsevier.
2. BELLUCCI, G., CHIAPPE, C., PUCCI, L. & GERVASI, P.G. (1996). The mechanism of oxidation of allylic alcohol to α-, β-unsaturated chetones by cytochrome P450. Chem. Res. Toxicol., 9, 871-874.
3. BLOOM, S.E. (1983). Detection of sister chromatid exchange in vivo using avian embryos. In Cytogenetic Assays of Environmental Mutagens, ed. Hsu, T.C. pp. 137-159. Totowa, N.J.: Allanheld Osmun.
4. BOX, G.E.P. & HUNTER, W.G. (1978). Statistics For Experiments, pp. 80-82. New York: Wiley.
5. BROOKER, J. & O'CONNOR, R. (1982). cDNA cloning and analysis of chick embryo liver cytochrome P450 mRNA induced by porphyrinogenic drugs. Eur. J. Biochem., 129, 325-333.
6. BRUNSTROM, B. (1986). Activities in chick embryos of 7-ethoxycoumarin O-deethylase and aryl hydrocarbon (benzo[a]pyrene) hydroxylase and their induction by 3,3′,4,4′-tetrachlorobiphenyls in early embryos. Xenobiotica, 16, 865-872.
7. BRUYERE, H.J. & STITH, C.E. (1993). Strain-dependent effect of ethanol on ventricular septal defect frequency in White Leghorn chick embryo. Teratology, 84, 299-303.
8. DICKERSON, R.E. (1971). The structure of cytochrome c and the rates of molecular evolution. J. Mol. Evol., 1, 26-45.
9. EDWARDS, R.J., SINGLETON, A.M., MURRAY, B.P., DAVIES, D.S. & BOOBIS, A.R. (1995). Short synthetic peptides exploited for reliable and specific targeting of antibodies to the c-termini of cytochrome P450 enzymes. Biochem. Pharmacol., 49, 39-47.
10. ESKOLA, J. & TOIVANEN, P. (1974). Effect of in ovo treatment with cyclophosphamide on lymphoid system in chicken. Cell. Immunity, 13, 459-471.
11. GONZALEZ, F.J. (1989). The molecular biology of cytochrome P450s. Pharmacol. Rev., 40, 243-288.
12. GONZALEZ, F.J. & NEBERT, D.W. (1990). Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet., 6, 182-187.
13. GUENGERICH, F.P. (1993). Metabolic reactions: types of reactions of cytochrome P450 enzyme. In Cytochrome P450 ed. Schenkman, J.B. & Greim, H. pp. 89-103. Berlin: Springer-Verlag.
14. GUPTA, R, LAPADULA, D. & ABOU-DONIA, M. (1990a). Purification and characterization of cytochrome P450 isozymes from phenobarbital adult hen liver. Comp. Biochem. Physiol., 96, 163-176.
15. GUPTA, R., LAPADULA, D. & ABOU-DONIA, M. (1990b). Purification and characterization of P450 isozymes from β-naphthoflavone-induced adult hen liver. Arch. Biochem. Biophys., 282, 170-182.
16. HAMILTON, J.W. & BLOOM, S.E. (1986). Correlation between induction of xenobiotic metabolism and DNA damage from chemical carcinogens in the chick embryo in vivo. Carcinogenesis, 7, 1101-1106.
17. HAMILTON, J.W., DENISON, M.S. & BLOOM, S.E. (1983). Development of basal and induced aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity in the chicken embryo in ovo. Proc. Natl. Acad. Sci. U.S.A., 80, 3372-3376.
18. HANSCH, C., SINCLAIR, J. & SINCLAIR, P.R. (1990). Induction of cytochrome P450 by barbiturates in chick embryo hepatocytes: a quantitative structure-activity analysis. Quant. Struct. Act. Relat., 9, 223-226.
19. HANSEN, A. & MAY, B. (1989). Sequence of chicken phenobarbital-inducible P450 cDNA: regulation of two P450 mRNAs transcribed from different genes. DNA, 8, 179-191.
20. HOBBS, A., MATTSCHOSS, L., MAY, B., WILLIAMS, K. & ELLIOT, W. (1986). The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P450. J. Biol. Chem., 261, 9444-9449.
21. HOKAMA, Y., KOGA, N. & YOSHIMURA, H. (1988). Purification and characterization of two forms of chicken liver cytochrome P450 induced by 3,4,5,3′,4′-pentachlorobiphenyl. J. Biochem., 104, 355-361.
22. JUCHAU, M.R., GIACHELLI, C.M., FANTEL, A.G., GREENAWAY, J.C., SHEPARD, T.H. & FAUSTMAN-WATTS, E.M. (1985). Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis. Toxicol. Appl. Pharmacol., 80, 137-146.
23. KAMINSKY, L.S., KANNAN, G.A. & GUENGERICH, F.P. (1984). Composition of cytochrome P450 isozymes from hepatic microsomes of c57BL/6 and DBA 2 mice assessed by warfarin metabolism, immunoinhibition and immunoelectrophoresis with anti-(rat cytochrome P450). Eur. J. Biochem., 141, 141-143.
24. nd Edition. Berlin: Springer Verlag.
25. LORR, N.A. & BLOOM, S.E. (1987). Ontogeny of the chicken cytocrome P450 enzyme system: expression and development of responsiveness to phenobarbital induction. Biochem. Pharmacol., 36, 3059-3067.
26. LORR, N.A., BLOOM, S.E., PARK, S.S., GELBOIN, H.V., MILLER, H. & FRIEDMAN, F.K. (1989). Evidence for PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbital-inducible forms. Mol. Pharmacol., 35, 610-616.
27. LOWRY, O.H., ROSEBROUGH, H.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
28. LUBET, R.A., DRAGNEV, K.A., CHAUHAN, D.P., NIMS, R.W., DIWAN, B.A., WARD, J.M., JONES, C.R., RICEAND, J.M. & MILLER, M.S. (1992). A pleiotropic response to phenobabital-type enzyme inducers in the F344/NCr rat. Biochem. Pharmacol., 43, 1067-1078.
29. LUBET, R.A., MAYER, M.J., CAMERON, J.W., BURKE, D.M., WOLF, T. & GUENGERICH, F.P. (1985). Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in rat. Arch. Biochem. Biophys., 238, 43-48.
30. MURRAY, M. & RESIDY, G.F. (1990). Selectivity inhibition of mammalian cytochrome P450 by chemical agents. Pharmacol. Rev., 42, 85-101.
31. NAKAI, K., WARD, A.M., GANNON, M. & RIFKIND, A. (1992). β-Naphthoflavone induction of a cytochrome P450 arachidonic acid epoxygenase in chick embryo liver distinct from the arylhydrocarbon hydroxylase and from phenobarbital-induced arachidonic epoxygenase. J. Biol. Chem., 267, 19503-19512.
32. NEBERT, D.W. & GONZALEZ, F.J. (1987). P450 genes: structure evolution and regulation. Ann. Rev. Biochem., 56, 945-993.
33. NELSON, D.R., KOYMANS, L., KAMATAKI, T., STEGEMAN, J.J., FEYEREISEN, D., WAXMAN, J., WATERMAN, M.R., GOTOH, O., COON, M.J., ESTABROOK, R.W., GUNSALUS, I.C. & NEBERT, D.W. (1996). P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42.
34. NELSON, D.R. & STROBEL, H.W. (1987). Evolution of cytochrome P450 protein. Mol. Biol. Evol., 4, 572-593.
35. PAOLINI, M., MESIRCA, R., POZZETTI, L., SAPONE, A. & CANTELLI-FORTI, G. (1995). Induction of CYP 2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers. Chem. Biol. Inter., 95, 127-139.
36. PAOLINI, M., POZZETTl, L., MESIRCA, R., SAPONE, A. & CANTELLIFORTI, G. (1996a). Testosterone hydroxylase in evaluating induction and suppression of murine CYP isoenzymes by fenarimol. Arch. Toxicol., 70, 451-456.
37. PAOLINI, M., POZZETTI, L., PEDULLI, G.F., CIPOLLONE, M., MESIRCA, R. & CANTELLI-FORTI, G. (1996b). Paramagnetic resonance in detecting carcinogenic risk from cytochrome P450 overexpression. J. Invest. Med (Clin. Res.), 44, 470-473.
38. PLATT, J., MOLITOR, E., DOEHMER, J., DOGRA, S. & OESCH, F. (1989). Genetically engineered V79 Chinese hamster cell. Expression of purified cytochrome P450 2B1 monooxygenase activity. Biochem. Toxicol., 4, 1-5.
39. POWIS, G., DRUMMOND, H., MACINTYRE, D.E. & JONDORF, W.R. (1976). Development of liver microsomal oxidations in the chick. Xenobiotica, 6, 69.
40. RIFKIND, A.B., GILLETTE, P.N., SONG, C.S. & KAPPAS, A. (1973). Drug stimulation of δ-aminolevulinic acid synthetase and cytocrome P450 in vivo in chick embryo liver. J. Pharmacol. Exp. Ther., 185, 214-225.
41. SINCLAIR, J., CORNELL, N.W., ZAITLIN, L. & HANSCH, C. (1986). Induction of cytochrome P450 by alcohols and 4-substituted pyrazoles. Biochem. Pharmacol., 35, 705-710.
42. SINCLAIR, J., WOOD, S., LAMBRECHT, L., GORMAN, N., MENDEMUELLER, L., SMITH, L., HUNT, J. & SINCLAIR, P. (1990). Isolation of four forms of acetone-induced cytochrome P450 in chicken liver by HPLC and their enzymatic characterization. Biochem. J., 269, 85-91.
43. SINCLAIR, J.F. & SINCLAIR, P.R. (1993). Avian cytochrome P450. In Cytochrome P450, ed. Schenkman, J.B. & Greim, H. pp. 259-277. Berlin: Springer-Verlag.
44. SPEAKE, B.K., NOBELE, R.C. & MCCARTNEY, R. (1992). Lipoprotein lipase activity in tissues of the developing chick embryo. Biochem. Soc. Trans., 20, 295S.
45. SPENCER, C.B. & RIFKIND, A.B. (1990). NAD(P)H: quinone oxidoreductase (DT-diaphorase) in chick embryo liver. Comparison to activity in rat and guinea pig liver and differences in coinduction with 7-ethoxyresorufin deethylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Pharmacol., 3, 327-335.
46. STRITTMEYER, C. & UMBERGER, F. (1969). Oxidative enzyme components of avian liver microsomes. Biochem. Biophys. Acta, 180, 18-27.
47. THOMAS, K.R. & CAPECCHI, M.R. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell, 51, 503-512.
48. TODD, L.A. & BLOOM, S.E. (1980). Differential induction of sister chromatid exchange by indirect acting mutagen-carcinogens at early and late stage of embryonic development. Environ. Mutagen., 2, 435-445.
49. VAN DER HOEVEN, T.H. (1984). Assay of hepatic microsomal testosterone hydroxylases by high-performance liquid chromatography. Anal. Biochem., 138, 57-65.
50. VAN MIEROP, L.H.S. (1967). Location of pacemarker in chick embryo heart at the time of initiation of heartbeat. Am. J. Physiol., 212, 407-415.
51. VESELY, D., VESELA, D. & JELINEK, R. (1992). Embryotoxicity of 2-toxin and secalonic acid in embryonic chicks varies with the site of administration. Teratology, 46, 131-136.
52. WAAD, A.W., SWINNEY, D.C., THOMAS, P.E., RYAN, D.E., HALL, P.F., LEVIN, W. & GARLAND, W.A. (1988). Mechanism of androstenedione formation from testosterone and episterone catalyzed by purified cytochrome P450b. J. Biol. Chem., 33, 17322-17332.
53. WAXMAN, D., DANNAN, G. & GUENGERlCH, F. (1985). Regulation of rat hepatic cytochrome P450: age-dependent expression, hormonal imprinting and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry, 24, 4409-4417.