Chemoprevention of cancer: Lessons to be learned from beta-carotene trials

Toxicology Letters

Volumn 112-113, Issue , 2000, Pages 513-517

  Vainio, Harri ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cancer; Carotenoids; Chemoprevention; Intervention

Indexed keywords

ALPHA TOCOPHEROL; ASBESTOS; BETA CAROTENE;

CANCER PREVENTION; CARDIOVASCULAR DISEASE; CHEMOPROPHYLAXIS; CONFERENCE PAPER; DIET; HUMAN; LUNG CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SMOKING;

ANTIOXIDANTS; BETA CAROTENE; CARDIOVASCULAR DISEASES; CHEMOPREVENTION; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEOPLASMS;

EID: 0034653357     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00208-8     Document Type: Conference Paper

References (14)

1. Albanes D., Heinonen O.P., Taylor P.R., Virtamo J., Edwards B.K., Rautalahti M., Hartman A.M., Palmgren J., Freedman L.S., Haapakoski J., Barret M.J., Pietinen P., Malila N., Tala E., Liippo K., Salomaa E.R., Tangrea J.A., Teppo L., Askin F.B., Taskinen E., Erozan Y., Greenwald P., Huttunen J.K. Alpha-tocopherol and beta-carotene supplement and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl. Cancer Inst. 88:1996;1560-1570.
2. ATBC. Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group, 1994. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330, 1029-1035.
3. Fuchs C.S., Giovannucci E.L., Colditz G.A., Hunter D.J., Stampfer M.J., Rosner B., Speizer F.E., Willett W.C. Dietary fiber and the risk of colorectal cancer and adenoma in women. N. Engl. J. Med. 340:1999;169-176.
4. Heinonen O.P., Albanes D., Virtamo J., Taylor P.R., Huttunen J.K., Hartman A.M., Haapakoski J., Malila N., Rautalahti M., Ripatti S., Maenpaa H., Teerenhovi L., Koss L., Virolainen M., Edwards B.K. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J. Natl. Cancer Inst. 90:1998;440-446.
5. Heinonen O.P. Controlled trials and chemoprevention of cancer. Acta Oncol. 37:1998;231-234.
6. Hennekens C.H., Buring J.E., Manson J.E., Stampfer M., Rosner B., Cook N.R., Belanger C., LaMotte F., Gaziano J.M., Ridker P.M., Willett W., Peto R. Lack of effect of long-term supplementation with beta-carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 334:1996;1145-1149.
7. Howe G.R., Benito E., Castelleto R., Cornee J., Esteve J., Gallagher R.P., Iscovich J.M., Deng-ao J., Kaaks R., Kune G.A. et al. Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from combined analysis of 13 case-control studies. J. Natl. Cancer Inst. 84:1992;1887-1896.
8. IARC, 1997. Non-Steroidal Anti-inflammatory Drugs. IARC Handbooks of Cancer Prevention, vol 1, International Agency for Research on Cancer, Lyon, pp 1-202.
9. IARC, 1998. Carotenoids. IARC Handbooks of Cancer Prevention, vol 2, International Agency for Research on Cancer, Lyon, pp.1-326.
10. IARC, 1998. Vitamin A. IARC Handbooks of Cancer Prevention, vol 3, International Agency for Research on Cancer, Lyon, pp 1-261.
11. IARC, 1999. Retinoids. IARC Handbooks of Cancer Prevention, vol 4, International Agency for Research on Cancer, Lyon (in press).
12. Omenn G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., Keogh J.P., Meyskens F.L., Valanis B., Williams J.H., Barnhart S., Hammar S. Effects of a combination of beta-carotene and vitamin A on the lung cancer incidence, total mortality, and cardiovascular mortality in smokers and asbestos-exposed workers. N. Engl. J. Med. 334:1996;1150-1155.
13. Steinmetz K.A., Potter J.D. Vegetables, fruit and cancer prevention: a review. J. Am. Diet Assoc. 96:1996;1027-1039.
14. Vainio H., Rautalahti M. An international evaluation of the cancer preventive potential of carotenoids. Cancer Epi. Biomarkers Prev. 7:1998;725-728.