메뉴 건너뛰기




Volumn 58, Issue 10, 1999, Pages 1529-1537

Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line

Author keywords

Genetic complementation; Mutagenesis; Point mutation; Protein deficiency; Thymidine; Thymidylate synthase

Indexed keywords

THYMIDINE; THYMIDYLATE SYNTHASE;

EID: 0032872004     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00237-3     Document Type: Article
Times cited : (14)

References (39)
  • 1
    • 0029036377 scopus 로고
    • The catalytic mechanism and structure of thymidylate synthase
    • Carreras C.W., Santi D.V. The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem. 64:1995;721-762.
    • (1995) Annu Rev Biochem , vol.64 , pp. 721-762
    • Carreras, C.W.1    Santi, D.V.2
  • 2
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5-fluorouracil
    • Parker W.B., Cheng Y.C. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther. 48:1990;381-395.
    • (1990) Pharmacol Ther , vol.48 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 3
    • 0020957578 scopus 로고
    • Human leukemic cells resistant to 5-fluoro-2′-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides
    • Bapat A.R., Zarow C., Danenberg P.V. Human leukemic cells resistant to 5-fluoro-2′-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J Biol Chem. 258:1983;4130-4136.
    • (1983) J Biol Chem , vol.258 , pp. 4130-4136
    • Bapat, A.R.1    Zarow, C.2    Danenberg, P.V.3
  • 4
    • 0020504093 scopus 로고
    • Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant Ehrlich ascites carcinoma cells
    • Jastreboff M.M., Kedzierska B., Rode W. Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant Ehrlich ascites carcinoma cells. Biochem Pharmacol. 32:1983;2259-2267.
    • (1983) Biochem Pharmacol , vol.32 , pp. 2259-2267
    • Jastreboff, M.M.1    Kedzierska, B.2    Rode, W.3
  • 6
    • 0025845346 scopus 로고
    • Induction of megabase DNA fragments by 5-fluorodeoxyuridine in human colorectal tumor (HT29) cells
    • Dusenbury C.E., Davis M.A., Lawrence T.S., Maybaum J. Induction of megabase DNA fragments by 5-fluorodeoxyuridine in human colorectal tumor (HT29) cells. Mol Pharmacol. 39:1991;285-289.
    • (1991) Mol Pharmacol , vol.39 , pp. 285-289
    • Dusenbury, C.E.1    Davis, M.A.2    Lawrence, T.S.3    Maybaum, J.4
  • 7
    • 0019819087 scopus 로고
    • Selection of thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate
    • Ayusawa D., Koyama H., Iwata K., Seno T. Selection of thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate. Somat Cell Genet. 7:1981;523-534.
    • (1981) Somat Cell Genet , vol.7 , pp. 523-534
    • Ayusawa, D.1    Koyama, H.2    Iwata, K.3    Seno, T.4
  • 8
    • 0021272317 scopus 로고
    • Mutants of Chinese hamster cells deficient in thymidylate synthetase
    • Li I.-C., Chu E.H.Y. Mutants of Chinese hamster cells deficient in thymidylate synthetase. J Cell Physiol. 120:1984;109-116.
    • (1984) J Cell Physiol , vol.120 , pp. 109-116
    • Li, I.-C.1    Chu, E.H.Y.2
  • 9
    • 0022371692 scopus 로고
    • Thymidylate synthase-deficient Chinese hamster cells: A selection system for the study of thymidylate synthase regulation and fragile X expression
    • Nussbaum R.L., Walmsley R.M., Lesko J.G., Airhart S.D., Ledbetter D.H. Thymidylate synthase-deficient Chinese hamster cells A selection system for the study of thymidylate synthase regulation and fragile X expression . Am J Hum Genet. 37:1985;1192-1205.
    • (1985) Am J Hum Genet , vol.37 , pp. 1192-1205
    • Nussbaum, R.L.1    Walmsley, R.M.2    Lesko, J.G.3    Airhart, S.D.4    Ledbetter, D.H.5
  • 11
    • 0028001422 scopus 로고
    • Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells
    • Houghton J.A., Harwood F.G., Houghton P.J. Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells. Cancer Res. 54:1994;4967-4973.
    • (1994) Cancer Res , vol.54 , pp. 4967-4973
    • Houghton, J.A.1    Harwood, F.G.2    Houghton, P.J.3
  • 12
    • 0030808385 scopus 로고    scopus 로고
    • Thymineless death in colon carcinoma cells is mediated via Fas signaling
    • Houghton J.A., Harwood F.G., Tillman D.M. Thymineless death in colon carcinoma cells is mediated via Fas signaling. Proc Natl Acad Sci USA. 94:1997;8144-8149.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8144-8149
    • Houghton, J.A.1    Harwood, F.G.2    Tillman, D.M.3
  • 13
    • 0027081148 scopus 로고
    • A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2′-deoxyuridine in mammalian and bacterial cells
    • Barbour K.W., Hoganson D.K., Berger S.H., Berger F.G. A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2′-deoxyuridine in mammalian and bacterial cells. Mol Pharmacol. 42:1992;242-248.
    • (1992) Mol Pharmacol , vol.42 , pp. 242-248
    • Barbour, K.W.1    Hoganson, D.K.2    Berger, S.H.3    Berger, F.G.4
  • 14
    • 0032496226 scopus 로고    scopus 로고
    • Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells
    • Tong Y., Liu-Chen X., Ercikan-Abali E.A., Capiaux G.M., Zhao S.-C., Banerjee D., Bertino J.R. Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells. J Biol Chem. 273:1998;11611-11618.
    • (1998) J Biol Chem , vol.273 , pp. 11611-11618
    • Tong, Y.1    Liu-Chen, X.2    Ercikan-Abali, E.A.3    Capiaux, G.M.4    Zhao, S.-C.5    Banerjee, D.6    Bertino, J.R.7
  • 15
    • 0026503987 scopus 로고
    • Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates
    • Houghton P.J., Rahman A., Will C.L., Dolnick B.J., Houghton J.A. Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates. Cancer Res. 52:1992;558-565.
    • (1992) Cancer Res , vol.52 , pp. 558-565
    • Houghton, P.J.1    Rahman, A.2    Will, C.L.3    Dolnick, B.J.4    Houghton, J.A.5
  • 16
    • 0344734178 scopus 로고    scopus 로고
    • A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase
    • Williams A.W., Dunlap R.B., Berger S.H. A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase. Biochemistry. 37:1998;7096-7102.
    • (1998) Biochemistry , vol.37 , pp. 7096-7102
    • Williams, A.W.1    Dunlap, R.B.2    Berger, S.H.3
  • 17
    • 0024592519 scopus 로고
    • Modulation of 5-fluoro-2′-deoxyuridine response by folinic acid in human colonic tumor cell lines: The role of thymidylate synthase
    • Davis S.T., Berger S.H. Modulation of 5-fluoro-2′-deoxyuridine response by folinic acid in human colonic tumor cell lines The role of thymidylate synthase . Mol Pharmacol. 35:1989;422-427.
    • (1989) Mol Pharmacol , vol.35 , pp. 422-427
    • Davis, S.T.1    Berger, S.H.2
  • 19
    • 0020609120 scopus 로고
    • Characterization of human colon carcinoma cell lines isolated from a single primary tumor
    • Brattain M.G., Marks M.E., McCombs J., Finely W., Brattain D.E. Characterization of human colon carcinoma cell lines isolated from a single primary tumor. Br J Cancer. 47:1983;373-381.
    • (1983) Br J Cancer , vol.47 , pp. 373-381
    • Brattain, M.G.1    Marks, M.E.2    McCombs, J.3    Finely, W.4    Brattain, D.E.5
  • 20
    • 0027214923 scopus 로고
    • Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2′-deoxyuridine
    • Davis S.T., Berger S.H. Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2′-deoxyuridine. Mol Pharmacol. 43:1993;702-708.
    • (1993) Mol Pharmacol , vol.43 , pp. 702-708
    • Davis, S.T.1    Berger, S.H.2
  • 21
    • 0023733092 scopus 로고
    • Thymidylate synthase as a determinant of 5-fluoro-2′-deoxyuridine response in human colonic tumor cell lines
    • Berger S.H., Berger F.G. Thymidylate synthase as a determinant of 5-fluoro-2′-deoxyuridine response in human colonic tumor cell lines. Mol Pharmacol. 34:1988;474-479.
    • (1988) Mol Pharmacol , vol.34 , pp. 474-479
    • Berger, S.H.1    Berger, F.G.2
  • 22
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 27
    • 0028301255 scopus 로고
    • Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability
    • Umar A., Boyer J.C., Thomas D.C., Nguyen D.C., Risinger J.I., Boyd J., Ionov Y., Perucho M., Kunkel T.A. Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem. 269:1994;14367-14370.
    • (1994) J Biol Chem , vol.269 , pp. 14367-14370
    • Umar, A.1    Boyer, J.C.2    Thomas, D.C.3    Nguyen, D.C.4    Risinger, J.I.5    Boyd, J.6    Ionov, Y.7    Perucho, M.8    Kunkel, T.A.9
  • 30
    • 0025281682 scopus 로고
    • The structure of mutation in mammalian cells
    • Meuth M. The structure of mutation in mammalian cells. Biochim Biophys Acta. 1032:1990;1-17.
    • (1990) Biochim Biophys Acta , vol.1032 , pp. 1-17
    • Meuth, M.1
  • 31
    • 0025362253 scopus 로고
    • Molecular evidence that homologous recombination occurs in proliferating human somatic cells
    • Groden J., Nakamura Y., German J. Molecular evidence that homologous recombination occurs in proliferating human somatic cells. Proc Natl Acad Sci USA. 87:1990;4315-4319.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4315-4319
    • Groden, J.1    Nakamura, Y.2    German, J.3
  • 32
    • 0029101616 scopus 로고
    • Inactivation of the mouse msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
    • de Wind N., Dekker M., Berns A., Radman M., te Riele H. Inactivation of the mouse msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell. 82:1995;321-330.
    • (1995) Cell , vol.82 , pp. 321-330
    • De Wind, N.1    Dekker, M.2    Berns, A.3    Radman, M.4    Te Riele, H.5
  • 33
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A., Dixit V.M. Death receptors Signaling and modulation . Science. 281:1998;1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 34
    • 0023971856 scopus 로고
    • Functional role of cysteine-146 in Escherichia coli thymidylate synthase
    • Dev I.K., Yates B.B., Leong J., Dallas W.S. Functional role of cysteine-146 in Escherichia coli thymidylate synthase. Proc Natl Acad Sci USA. 85:1988;1472-1476.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1472-1476
    • Dev, I.K.1    Yates, B.B.2    Leong, J.3    Dallas, W.S.4
  • 35
    • 0025372246 scopus 로고
    • Escherichia coli thymidylate synthase: Amino acid substitutions by suppression of amber nonsense mutations
    • Michaels M.L., Kim C.W., Matthews D.A., Miller J.H. Escherichia coli thymidylate synthase Amino acid substitutions by suppression of amber nonsense mutations . Proc Natl Acad Sci USA. 87:1990;3957-3961.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3957-3961
    • Michaels, M.L.1    Kim, C.W.2    Matthews, D.A.3    Miller, J.H.4
  • 38
    • 0032476056 scopus 로고    scopus 로고
    • Random sequence mutagenesis and resistance to 5-fluorodeoxyuridine in human thymidylate synthase
    • Landis D.M., Loeb L.A. Random sequence mutagenesis and resistance to 5-fluorodeoxyuridine in human thymidylate synthase. J Biol Chem. 273:1998;25809-25817.
    • (1998) J Biol Chem , vol.273 , pp. 25809-25817
    • Landis, D.M.1    Loeb, L.A.2
  • 39
    • 0024315761 scopus 로고
    • Studies on the mechanism of methanol poisoning: Purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase
    • Johlin F.C., Swain E., Smith C., Tephly T.R. Studies on the mechanism of methanol poisoning Purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase . Mol Pharmacol. 35:1989;745-750.
    • (1989) Mol Pharmacol , vol.35 , pp. 745-750
    • Johlin, F.C.1    Swain, E.2    Smith, C.3    Tephly, T.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.