Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma

Journal of Clinical Oncology

Volumn 16, Issue 4, 1998, Pages 1465-1469

  Gorlick, Richard ^a   Metzger, Ralf ^a   Danenberg, Kathleen D ^a   Salonga, Dennis ^a   Miles, Joseph S ^a   Longo, Guiseppe S A ^a   Fu, Jenny ^a   Banerjee, Debabrata ^a   Klimstra, David ^a   Jhanwar, Suresh ^a   Danenberg, Peter V ^a   Kemeny, Nancy ^a   Bertino, Joseph R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MESSENGER RNA; METHOTREXATE; PROTEIN P53; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LUNG METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

EID: 0031947357     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.4.1465     Document Type: Article

References (24)

1. Boring CC, Squires TS, Tong T: Cancer statistics 1993. CA 43:7-26, 1993
2. Belluco C, Guillem JG, Kemeny N, et al: p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 14:2696-2701, 1996
3. Weiss L, Grundmann E, Torhost J, et al: Hematogenous metastatic patterns in colonic carcinoma: An analysis of 1541 necropsies. J Pathol 150:195-203, 1986
4. Hughes K, Scheele J, Sugarbaker PH: Surgery for colorectal cancer metastatic to the liver. Surg Clin North Am 69:340-359, 1989
5. McCormack PM, Attiyeh FF: Resected pulmonary metastases from colorectal cancer. Dis Colon Rect 22:553-556, 1979
6. Girard P, Ducreux M, Baldeyrou P, et al: Surgery for lung metastases from colorectal cancer: Analysis of prognostic factors. J Clin Oncol 14:2047-2053, 1996
7. Rustum YM, Harstrick A, Cao S, et al: Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors. J Clin Oncol 15:389-400, 1997
8. Moertel CG, Reitemeier RJ: Clinical features influencing therapeutic response to fluorinated pyrimidines, in Moertel CG, Reitemeier RJ (eds): Advanced Gastrointestinal Cancer - Clinical Management and Chemotherapy. New York, NY, Harper & Row, 1969, pp 122-125
9. Poon MA, O'Connell MJ, Moertel CG, et al: Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7:1407-1414, 1989
10. Lenz HJ, Leichman CG, Danenberg KD, et al: Thymidylate synthase mRNA level in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival. J Clin Oncol 14:176-182, 1996
11. Leichman L, Lenz HJ, Leichman CG, et al: Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial. Eur J Cancer 31A:1306-1310, 1995
12. Johnston PG, Lenz HJ, Leichman CG, et al: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55:1407-1412, 1995
13. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
14. Bradford M: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254, 1976
15. Horikoshi T, Danenberg KD, Stadbauer THW, et al: Quantitation of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 52:108-116, 1992
16. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503-517, 1975
17. Baas IO, Mulder JR, Offerhaus GJA, et al: An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J Pathol 172:5-12, 1994
18. Livingstone LR, White A, Sprouse J, et al: Altered cell cycle arrest and gene amplification potential accompany loss of wild type p53. Cell 70:923-935, 1992
19. Yin Y, Tainsky MA, Bischoff FZ: Wild type p53 restores cell cycle control and inhibits gene amplification in cells without mutant p53 alleles. Cell 70:937-948, 1992
20. Goker E, Waltham M, Kheradpour A, et al: Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia and is correlated with p53 gene mutations. Blood 86:677-684, 1995
21. Li WW, Lin JT, Tong WP, et al: Mechanisms of natural resistance to antifolates in soft tissue sarcomas. Cancer Res 52:1434-1438, 1992
22. 1S-regulatory genes. Mol Cell Biol 15:4215-4224, 1995
23. Fan J, Bertino JR: Functional roles of E2F in cell cycle regulation. Oncogene 14:1191-1200, 1997
24. Li WW, Fan J, Hochhauser D, et al: Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci USA 92:10436-10440, 1995