CR (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions

Molecular and Cellular Biochemistry

Volumn 222, Issue 1-2, 2001, Pages 199-204

  Qian, Y ^a   Jiang, B ^a   Flynn, D C ^a   Leonard, S S ^b   Wang, S ^b   Zhang, Z ^b   Ye, J ^b   Chen, F ^b   Wang, L ^b   Shi, X ^b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

A549 cells; Cr (VI); Tyrosine phosphorylation

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ANTIOXIDANT; CARCINOGEN; CATALASE; CHROMIUM; FORMATE SODIUM; FORMIC ACID DERIVATIVE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; OXYGEN; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; EPITHELIUM CELL; HUMAN; HUMAN CELL; INCUBATION TIME; LUNG ALVEOLUS EPITHELIUM; MEASUREMENT; MOLECULAR BIOLOGY; OXYGEN CONSUMPTION; PROTEIN PHOSPHORYLATION; TIME;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CATALASE; CELL LINE; CHROMIUM; EPITHELIAL CELLS; FORMIC ACIDS; HEMOSTATICS; HUMANS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LUNG; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; TIME FACTORS;

EID: 0034802507     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017926531890     Document Type: Article

References (33)

1. Genotoxicity of chromium compounds: A review
2. Reduction of chromium (VI) and its relationship to carcinogenesis
3. Mechanism of chromium metabolism and genotoxicity
4. DNA damage induced by carcinogenic lead chromate particles in cultured mammalian cells
5. Role of molecular oxygen in the generation of hydroxyl and superoxide anion radicals during enzymatic Cr(VI) reduction and its implication to Cr(VI)-induced carcinogenesis
6. DNA damage induced by carcinogenic lead chromate particles in cultured mammalian cells
7. Generation of PM2 DNA breaks in the course of reduction of chromium (VI) by glutathione
8. Review of occupational epidemiology of chromium chemicals and respiratory cancer
9. One hundred years of chromium and cancer: A review of epidemiological evidence and selected case reports
10. Metabolism of the carcinogenic chromate by cellular constituents
11. Mechanism of chromium carcinogenicity and toxicity
12. Role of reactive oxygen species and p53 in chromium (VI)-induced apoptosis
13. Chromium (VI)-induced nuclear factor-κB activation in intact cells via free radical reactions
14. Participation of MAP kinase p38 and IκB kinase in chromium (VI)-induced NF-κB and AP-1 activation
15. The role of hydroxyl radical as a messenger in Cr (VI)-induced p53 activation
16. Activation of JNK, p38, and ERK mitogen-activated protein kinase by chromium (VI) is mediated through oxidative stress but does not affect cytotoxicity
17. Roles of JNK, p38 and ERK mitogen-activated protein kinase in the growth inhibition and apoptosis induced by cadmium
18. Reactive oxygen species activate focal adhesion kinase, paxillin and tyrosine phosphorylation in endothelial cells
19. The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: Its role in cell growth and disease
20. Receptor signaling: When dimerization is not enough
21. Regulation, substrates and functions of src
22. Tyrosine-phosphorylated proteins: Mediators of signal transduction from the tyrosine kinases
23. Protein tyrosine kinases and cancer
24. c-Src, receptor tyrosine kinases, and human cancer
25. Transcriptional regulation by extracellular signals: Mechanisms and specificity
26. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
27. Tyrosine phosphorylation of IκB-alpha activates NF-κB without proteolytic degradation of IκB alpha
28. ESR parameters of spin adducts
29. The role of free radicals in occupational and environmental lung diseases
30. Superoxides relay Ras protein's oncogenic message
31. Possible role of nitroxide and redox cell signaling in metal-induced toxicity and carcinogenesis: A review
32. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts