Role of molecular oxygen in the generation of hydroxyl and superoxide anion radicals during enzymatic Cr(VI) reduction and its implication to Cr(VI)-induced carcinogenesis

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 19, Issue 1-2, 2000, Pages 49-60

  Leonard, S ^a   Wang, S ^a   Zang, L ^a   Castranova, V ^a   Vallyathan, V ^a   Shi, X ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Chromium carcinogenesis; Electron spin resonance; Hydroxyl radicals; Metal chelators; Molecular oxygen; Superoxide anion radicals

Indexed keywords

1,10 PHENANTHROLINE; ARGON; CATALASE; CHELATE; CHROMIUM; DEFEROXAMINE; DNA; EDETIC ACID; FORMIC ACID; GLUTATHIONE REDUCTASE; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; NITROXIDE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCOPOLETIN; SUPEROXIDE;

ARTICLE; CARCINOGENESIS; CHEMICAL REACTION; CONTROLLED STUDY; DNA DAMAGE; ELECTRON SPIN RESONANCE; FLUORESCENCE; PRIORITY JOURNAL; REACTION ANALYSIS; REDUCTION;

CARCINOGENICITY TESTS; CARCINOGENS; CHELATING AGENTS; CHROMIUM; DEFEROXAMINE; DNA; DNA DAMAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; NADP; OXIDATION-REDUCTION; OXYGEN; OXYGEN CONSUMPTION; SUPEROXIDES;

EID: 0034424697     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Genotoxicity of chromium compounds: A review
2. Toxicity and mutagenicity of hexavalent chromium on Salmonella typhimurium
3. Chromosomal aberrations and sister-chromatid exchanges in chinese hamster cells treated in vitro with hexavalent chromium compounds
4. One hundred years of chromium and cancer: A review of epidemiological evidence and selected case reports
5. Metabolism of the carcinogenic chromate by cellular constituents
6. Chromium(V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium(VI)
7. On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically generated chromium(V) species
8. Evidence for a Fenton-type mechanism for the generation of •OH radical in the reduction of Cr(VI) in cellular media
9. Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: Role of a Cr(IV)-mediated Fenton-like reaction
10. Reduction of chromium(VI) and its relationship to carcinogenesis
11. On the mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an insoluble Cr(V) intermediate
12. Chromate-induced chromium(V) formation in live mice and its control by cellular antioxidants: An L-band electron paramagnetic resonance study
13. Oxidative DNA damage by crystalline silica
14. ESR parameters of spin adducts
15. 2 in the presence of chelators in relation to DNA damage and 2′-deoxyguanosine hydroxylation
16. The role of superoxide radical in chromium(VI) generated hydroxyl radical: The Haber-Weiss cycle
17. Cr(III)-mediated hydroxyl radical generation via Haber-Weiss cycle
18. The structure of the flavoenzyme glutathione reductase
19. Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?
20. Spectrophotometric and ESR evidence for vanadium(IV) deferoxamine complexes
21. Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 mm) radiation: Evidence for the involvement of the hydroxyl radical
22. o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation
23. Influence of o-phenanthroline on DNA single-strand breaks, alkali-labile sites, glutathione reductase, and formation of chromium(V) in chinese hamster V-79 cells treated with sodium chromate(VI)
24. An oxygen dependence in chromium mutagenesis
25. ESR evidence for superoxide, hydroxyl and singlet oxygen produced from hydrogen peroxide and nickel(II) complex of glycylglycyl-L-histidine
26. Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide