Dietary L-arginine and α-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms

Atherosclerosis

Volumn 141, Issue 1, 1998, Pages 31-43

  Böger, Rainer H ^a   Bode Böger, Stefanie M ^a   Phivthong Ngam, Laddaval ^a   Brandes, Ralf P ^a   Schwedhelm, Edzard ^a   Mügge, Andreas ^a   Böhme, Michael ^a   Tsikas, Dimitrios ^a   Frölich, Jürgen C ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Antioxidants; Atherosclerosis; Isoprostanes; Nitric oxide; Oxidized low density lipoproteins; Superoxide anions; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ARGININE; CHOLESTEROL; DRINKING WATER; NITRATE; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROSTAGLANDIN F2 ALPHA; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DIETARY INTAKE; DISEASE COURSE; DRUG EFFECT; HYPERCHOLESTEROLEMIA; INTIMA; MALE; MOLECULAR DYNAMICS; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; URINARY EXCRETION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0032487486     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00145-2     Document Type: Article

References (63)

1. Böger RH, Bode-Böger SM, Frölich JC The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications. Atherosclerosis. 127:1996;1-11.
2. Cooke JP, Tsao PS Is NO an antiatherogenic molecule? Arterioscler Thromb. 14:1994;653-655.
3. Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME Antiatherosclerotic effects of L-arginine in the hypercholesterolemic rabbit. J. Clin Invest. 90:1992;1168-1172.
4. Böger RH, Bode-Böger SM, Mügge A, Kienke S, Brandes R, Dwenger A, Frölich JC Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis. 117:1995;273-284.
5. Jacobs M, Plane F, Bruckdorfer KR Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta. Br J Pharmacol. 100:1990;21-26.
6. Witztum JL, Steinberg D Role of oxidized low density lipoprotein in atherogenesis. J. Clin Invest. 88:1991;1785-1792.
7. Heinecke JW, Baker L, Rosen H, Chait A Superoxide-mediated modification of low-density lipoprotein by arterial smooth muscle cells. J Clin Invest. 77:1986;757-761.
8. Hiramatsu K, Rosen H, Heinecke JW, Wolfbauer G, Chait A Superoxide initiates oxidation of low-density lipoprotein by human monocytes. Arteriosclerosis. 7:1987;55-60.
9. Morgan J, Smith JA, Wilkins GM, Leake DS Oxidation of low-density lipoprotein by bovine and porcine aortic endothelial cells and porcine endocardial cells in culture. Atherosclerosis. 102:1993;209-216.
10. Ylä-Herttuala S, Palinski W, Rosenfeld M et al. Evidence for the presence of oxidatively modified LDL in atherosclerotic lesions of rabbit and man. J Clin Invest. 284:1989;1086-1095.
11. Mügge A, Brandes RP, Böger RH et al. Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 24:1994;994-998.
12. - excretion as an indicator of nitric oxide formation in vivo during oral administration of L-arginine or L-NAME in rats. Clin Exp Pharmacol Physiol. 23:1996;11-15.
13. Bode-Böger SM, Böger RH, Alfke H et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation. 93:1996;85-90.
14. Roberts II LJ, Morrow JD The generation and actions of isoprostanes. Biochim Biophys Acta. 1345:1997;121-135.
15. 2α by human monocytes: discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2. J Biol Chem. 271:1996;8919-8924.
16. 2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol. 47:1994;1173-1177.
17. 2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. New Engl J Med. 332:1995;1198-1203.
18. 2-isoprostane) metabolites in human urine and plasma. J Biol Chem. 268:1993;4161-4169.
19. Patrono C, Fitzgerald GA Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arterioscler Thromb Vasc Biol. 17:1997;2309-2315.
20. Candipan RC, Wang BY, Buitrago R, Tsao PS, Cooke JP Regression or progression: dependency on vascular nitric oxide. Arterioscler Thromb Vasc Biol. 16:1996;44-50.
21. Böger RH, Bode-Böger SM, Brandes RP et al. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits. Comparison with lovastatin. Circulation. 906:1997;1282-1290.
22. Jialal I, Grundy SM Effect of combined supplementation with α-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation. Circulation. 88:1993;2780-2786.
23. Williams RJ, Motteram JM, Sharp CH, Gallagher PJ Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis. 94:1992;153-159.
24. Anderson TLG, Matz J, Ferns GAA, Anggard EE Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation. Atherosclerosis. 111:1994;39-45.
25. Godfried SL, Combs GF, Saroka JM, Dillingham LA Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E. Br J Nutr. 61:1989;607-617.
26. Esterbauer H, Striegl G, Puhl H, Rotheneder M Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 6:1989;67-75.
27. Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
28. 15N-labelled analogs. J Chromatogr B. 661:1994;185-191.
29. Bode-Böger SM, Böger RH, Kienke S, Junker W, Frölich JC Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Commun. 219:1996;598-603.
30. Fisher LD, van Belle G Multiple comparisons. Fisher LD, van Belle G Biostatistics. A Methodology for the Health Sciences. 1993;596-629 New York, Wiley.
31. Witztum JL The oxidation hypothesis of atherosclerosis. Lancet. 334:1994;793-795.
32. Ohara Y, Peterson TE, Harrison DG Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 91:1993;2546-2551.
33. Clancy RM, Leszczynska-Piziak J, Abramson SB Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest. 90:1992;1116-1121.
34. Mohazzab-H KM, Kaminski PM, Wolin MS NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol. 266:1994;2568-2572.
35. Kukreja RC, Kontos HA, Hess ML, Ellis EF PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res. 59:1986;612-619.
36. G-nitro-L-arginine methyl ester in the porcine isolated splenic artery are sensitive to cyclooxygenase and lipoxygenase inhibitors. Naunyn Schmiedeberg's Arch Pharmacol. 347:1993;115-118.
37. Rosenblum WI, Nishimura H, Nelson GH L-NMMA in brain microcirculation of mice is inhibited by blockade of cyclooxygenase and by superoxide dismutase. Am J Physiol. 262:1992;H1343-H1349.
38. Rajagopalan S, Kurz S, Münzel T et al. Angiotensin II mediated hypertension in the rat increases vascular superoxide anion production via membrane NADH/NADPH oxidase activation: contribution to alterations of vascular tone. J Clin Invest. 97:1996;1916-1923.
39. Pritchard KA, Groszek L, Smalley DM et al. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res. 77:1995;510-518.
40. Niu XF, Smith CW, Kubes P Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res. 74:1994;1133-1140.
41. --reactive species activate primed platelets in human whole blood. Am J Physiol. 264:1993;H1582-H1587.
42. Marui N, Offerman MK et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest. 92:1993;1866-1874.
43. Ueda A, Okuda K, Ohno S et al. NF-κB and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol. 153:1994;2052-2063.
44. Kubes P, Suzuki M, Granger DN Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA. 88:1991;4651-4655.
45. Radomski MW, Palmer RMJ, Moncada S Characterization of the L-arginine: nitric oxide pathway in human platelets. Br J Pharmacol. 101:1987;325-328.
46. Tsao PS, Theilmeier G, Singer AH, Leung LLK, Cooke JP L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler Thromb. 14:1994;1529-1533.
47. Zeiher AM, Fisslthaler B, Schray-Utz B, Busse R Nitric oxide modulates the expression of monocyte chemoattractant protein-1 in cultured human endothelial cells. Circ Res. 76:1995;980-986.
48. Tsao PS, Buitrago R, Chan JS, Cooke JP Fluid flow inhibits endothelial adhesiveness: NO and transcriptional regulation of VCAM-1. Circulation. 94:1996;1682-1689.
49. Peng HB, Libby P, Liao JK Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem. 270:1995;14214-14219.
50. Collins T. Endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion. Lab Invest. 5:1993;499-508.
51. Böger RH, Bode-Böger SM, Thiele W, Junker W, Alexander K, Frölich JC Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation. 95:1997;2068-2074.
52. 2α is increased in hypercholesterolemia. Arterioscler Thromb Vasc Biol. 17:1997;3230-3235.
53. Simon BC, Haudenschild CC, Cohen RA Preservation of endothelium-dependent relaxation in atherosclerotic rabbit aorta by probucol. J Cardiovasc Pharmacol. 21:1993;893-901.
54. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA. 81:1984;3883-3887.
55. Griffith OW, Stuehr DJ Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol. 57:1995;707-736.
56. Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. FEBS Lett. 334:1993;170-174.
57. Rubbo H, Radi R, Trujillo M et al. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem. 269:1994;26066-26075.
58. Frei B, Gaziano JM Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human low density lipoprotein to metal-ion dependent and -independent oxidation. J Lipid Res. 34:1993;2135-2145.
59. Philis-Tsimikas A, Witztum JL L-arginine may inhibit atherosclerosis through inhibition of LDL oxidation (Abstract). Circulation (Suppl). 92:1995;422.
60. Keaney JF, Gaziano JM, Xu A et al. Low-dose α-tocopherol improves and high-dose α-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J Clin Invest. 93:1994;844-851.
61. Fruebis J, Bird DA, Pattison J, Palinski W Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants. J Lipid Res. 38:1997;2455-2464.
62. Böger RH, Bode-Böger SM, Kienke S, Stan AC, Nafe R, Frölich JC. Dietary L-arginine decreases myointimal proliferation and vascular monocyte accumulation in cholesterol-fed rabbits. Atherosclerosis 1998;136:67-7.
63. Özer K, Palozza P, Boscoboinik D, Azzi A D-α-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells. FEBS Lett. 322:1993;307-310.