Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis

Critical Care Medicine

Volumn 27, Issue 5, 1999, Pages 959-964

  Wang, Ping ^a   Ba, Zheng F ^a   Cioffi, William G ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a  

^a RHODE ISLAND HOSPITAL   (United States)

Author keywords

Acetylcholine; Aortae; Cecal ligation and puncture; Endothelium derived nitric oxide; Nitroglycerin; Vascular endothelial cell function

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE MAGNESIUM; GLYCERYL TRINITRATE; NITRIC OXIDE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA, THORACIC; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM, VASCULAR; INFUSIONS, INTRAVENOUS; MALE; PROSPECTIVE STUDIES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TIME FACTORS;

EID: 0033053505     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199905000-00035     Document Type: Article

References (37)

1. 1. Chaudry IH: Cellular mechanisms in shock and ischemia and their correction. Am J Physiol 1983; 245:R117-R134
2. 2. Am J Physiol 1984; 246: R799-R804
3. 2 treatment. Am J Physiol 1985; 248: H804-H811
4. 2 restores the depressed cardiac output following trauma and severe hemorrhage even in the absence of blood resuscitation. Circ Shock 1992; 36: 277-283
5. 2. Surgery 1992; 112:150-158
6. 2 restores the depressed hepatocellular function and hepatic blood flow following hemorrhage and crystalloid resuscitation. J Surg Res 1991; 50: 368-374
7. 2 restores renal microcirculation following trauma and severe hemorrhage. Can J Physiol Pharmacol 1992; 70:349-357
8. 2 administration normalizes macrophage cyclic AMP and β-adrenergic receptors after hemorrhage and resuscitation. Am J Physiol 1994; 267:G52-G58
9. 2 on the altered hepatocyte signal transduction after hemorrhagic shock. Am J Physiol 1997; 272:G1347-G1354
10. 2 after trauma-hemorrahge and resuscitation restores the depressed cardiac performance. J Surg Res 1997; 69:159-165
11. 2 following hemorrhagic shock. Circ Shock 1983; 11:141-148
12. 2 therapy in sepsis. Am J Emergency Med 1984; 2:38-44
13. 2 improves energetics and decreases lethality. J Surg Res 1994; 56:537-542
14. 14. Ali A, Goldberg RN, Suguihara C, et al: Effects of ATP-magnesium chloride on the cardiopulmonary manifestations of group B streptococcal sepsis in the piglet. Pediatr Res 1996; 39:601-615
15. 15. Wang P, Ba ZF, Chaudry IH: Nitric oxide: To block or enhance its production during sepsis? Arch Surg 1994; 129:1137-1143
16. 16. Wang P, Ba ZF, Chaudry IH: Endothelium-dependent relaxation is depressed at the macro-and microcirculatory levels during sepsis. Am J Physiol 1995; 269:R988-R994
17. 17. Wang P, Wood TJ, Zhou M, et al: Inhibition of the biologic activity of tumor necrosis factor maintains vascular endothelial cell function during hyperdynamic sepsis. J Trauma 1996; 40: 694-701
18. 18. Chaudry IH, Wichterman KA, Baue AE: Effect of sepsis on tissue adenine nucleotide levels. Surgery 1979; 85:205-211
19. 19. Wang P, Chaudry IH: Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am J Physiol 1996; 270:R927-R938
20. 2 and precautions for its use in the study and treatment of shock and ischemia. Am J Physiol 1982; 242:R604-R605
21. 21. Wang P, Ba ZF, Chaudry IH: Endothelial cell dysfunction occurs very early following trauma-hemorrhage and persists despite fluid resuscitation. Am J Physiol 1993; 265:H973-H979
22. 22. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43:109-142
23. 23. Moss M, Gillespie MK, Ackerson L, et al: Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome. Crit Care Med 1996; 24:1782-1786
24. 24. Palmer RMJ, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327:524-526
25. 25. Parker JL, Adams HR: Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia. Circ Res 1993; 72:539-551
26. 26. Liu SF, Adcock IM, Old RW, et al: Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysaccharide treatment in vivo in the rat. Crit Care Med 1996; 24:1219-1225
27. 27. Lefer AM, Lefer DJ: Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Annu Rev Pharmacol Toxicol 1993; 33:71-90
28. 28. Szabó C, Thiemermann C: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 1994; 2:145-155
29. 2 following trauma-hemorrhage and resuscitation: Downregulation of inflammatory cytokine (TNF, IL-6) release. J Surg Res 1992; 52:364-371
30. 30. Palmer RMJ: The discovery of nitric oxide in the vessel wall: A unifying concept in the pathogenesis of sepsis. Arch Surg 1993; 128:396-401
31. 31. Zhou M, Wang P, Chaudry IH: Endothelial nitric oxide synthase is down-regulated during hyperdynamic sepsis. Biochim Biophys Acta 1997; 1335: 182-190
32. 32. Greenberg S, Xie J, Wang Y, et al: Tumor necrosis factor-alpha inhibits endothelium-dependent relaxation. J Appl Physiol 1993; 74:2394-2403
33. 33. Xie J, Wang Y, Lippton H, et al: Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide. Am Rev Respir Dis 1993; 148:627-636
34. 34. Aoki N, Siegfried M, Lefer AM: Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries. Am J Physiol 1989; 256:H1509-H1512
35. 35. Wang P, Ba ZF, Chaudry IH: Administration of tumor necrosis factor-α in vivo depresses endothelium-dependent relaxation. Am J Physiol 1994; 266:H2535-H2541
36. 36. Ertel W, Morrison MH, Wang P, et al: The complex pattern of cytokines in sepsis-Association between prostaglandins, cachectin and interleukins. Ann Surg 1991; 214:141-148
37. 37. Wang P, Ba ZF, Chaudry IH: Mechanism of hepatocellular dysfunction during early sepsis: Key role of increased gene expression and release of proinflammatory cytokines tumor necrosis factor and interleukin-6. Arch Surg 1997; 132:364-370