Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-β into murine knee joints

Laboratory Investigation

Volumn 78, Issue 2, 1998, Pages 133-142

  Glansbeek, Harrie L ^a   Van Beuningen, Henk M ^b   Vitters, Elly L ^b   Van Der Kraan, Peter M ^b   Van Den Berg, Wim B ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL MODEL; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; GLYCOPROTEIN SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADMINISTRATION, TOPICAL; AGGRECANS; ANIMALS; ARTHRITIS; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; EXTRACELLULAR MATRIX PROTEINS; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; LECTINS, C-TYPE; MALE; MICE; MICE, INBRED C57BL; PROSTAGLANDINS; PROTEOGLYCANS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0031941319     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Allen JB, Manthey CL, Hand AR, Ohura K, Ellingsworth L, and Wahl SM (1990). Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J Exp Med 171:231-247.
2. Andrews HJ, Edwards TA, Cawston TE, and Hazleman BL (1989). Transforming growth factor-beta causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro. Biochem Biophys Res Commun 162:144-150.
3. Asundi VK and Dreher KL (1992). Molecular characterization of vascular smooth muscle decorin: Deduced core protein structure and regulation of gene expression. Eur J Cell Biol 59:314-321.
4. Bermudez LE, Covaro G, and Remington J (1993). Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors. Infect Immun 61:4126-4130.
5. Bogdan C, Paik J, Vodovotz Y, and Nathan C (1992). Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. J Biol Chem 267:23301-23308.
6. Brennan FM, Chantry D, Turner M, Foxwell B, Maini R, and Feldmann M (1990). Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: Lack of effect on spontaneous cytokine production in joint cell cultures. Clin Exp Immunol 81:278-285.
7. Breuer B, Schmidt G, and Kresse H (1990). Non-uniform influence of transforming growth factor-beta on the biosynthesis of different forms of small chondroitin sulphate/ dermatan sulphate proteoglycan. Biochem J 269:551-554.
8. Campbell IK, Wojta J, Novak U, and Hamilton JA (1994). Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes: Down-regulation by tumor necrosis factor alpha and up-regulation by transforming growth factor-β and basic fibroblast growth factor. Biochim Biophys Acta 1226: 277-285.
9. Chandrasekhar S and Harvey AK (1988). Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation. Biochem Biophys Res Commun 157:1352-1359.
10. Cheifetz S, Weatherbee JA, Tsang ML, Anderson JK, Mole JE, Lucas R, and Massague J (1987). The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. Cell 48:409-415.
11. Cheifetz S, Hernandez H, Laiho M, ten Dijke P, Iwata KK, and Massague J (1990). Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms. J Biol Chem 265:20533-20538.
12. Chubinskaya S, Huch K, Mikecz K, Cs Szabo G, Hasty KA, Kuettner KE, and Cole AA (1996). Chondrocyte matrix metalloproteinase-8: Up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints. Lab Invest 74:232-240.
13. Collier S and Ghosh P (1988). The role of plasminogen in interleukin-1 mediated cartilage degradation. J Rheumatol 15:1129-1137.
14. Collier S and Ghosh P (1995). Effects of transforming growth factor beta on proteoglycan synthesis by cell and explant cultures derived from the knee joint meniscus. Osteoarthritis Cartilage 3:127-138.
15. Cooper WO, Fava RA, Gates CA, Cremer MA, and Townes AS (1992). Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumour necrosis factor or transforming growth factor-beta. Clin Exp Immunol 89:244-250.
16. Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, and Srimal S (1990). Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol 145:940-944.
17. Dubois CM, Ruscetti FW, Palaszynski EW, Falk LA, Oppenheim JJ, and Keller JR (1990). Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: Proposed mechanism of inhibition of IL-1 action. J Exp Med 172:737-744.
18. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ, Angel P, and Heath JK (1987). Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6:1899-1904.
19. Elford PR, Graeber M, Ohtsu H, Aeberhard M, Legendre B, Wishart WL, and MacKenzie AR (1992). Induction of swelling, synovial hyperplasia and cartilage proteoglycan loss upon intra-articular injection of transforming growth factor beta-2 in the rabbit. Cytokine 4:232-238.
20. Fava R, Olsen N, Keski Oja J, Moses H, and Pincus T (1989). Active and latent forms of transforming growth factor beta activity in synovial effusions. J Exp Med 169:291-296.
21. Fava RA, Olsen NJ, Postlethwaite AE, Broadley KN, Davidson JM, Nanney LB, Lucas C, and Townes AS (1991). Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: Implications for TGF-beta-driven synovial inflammation and hyperplasia. J Exp Med 173:1121-1132.
22. Glansbeek HL, van Beuningen HM, Vitters EL, Morris EA, van der Kraan PM, and van den Berg WB (1997). Bone morphogenetic protein-2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1α effects on proteoglycan synthesis and content. Arthritis Rheum 40:1020-1028.
23. Grover J and Roughley PJ (1995). Expression of cell-surface proteoglycan mRNA by human articular chondrocytes. Biochem J 309:963-968.
24. Gunther M, Haubeck HD, van de Leur E, Blaser J, Bender S, Gutgemann I, Fischer DC, Tschesche H, Greiling H, Heinrich PC, and Graeve L (1994). Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes. Arthritis Rheum 37:395-405.
25. Hamilton JA, Wojta J, Gallichio M, McGrath K, and Filonzi EL (1993). Contrasting effects of transforming growth factor-beta and IL-1 on the regulation of plasminogen activator inhibitors in human synovial fibroblasts. J Immunol 151: 5154-5161.
26. Harvey AK, Hrubey PS, and Chandrasekhar S (1991). Transforming growth factor-beta inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes. Exp Cell Res 195:376-385.
27. He CS, Wilhelm SM, Pentland AP, Marmer BL, Grant GA, Eisen AZ, and Goldberg GI (1989). Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci USA 86:2632-2636.
28. Hughes CE, Caterson B, Fosang AJ, Roughley PJ, and Mort JS (1995). Monoclonal antibodies that specifically recognize neoepitope sequences generated by "aggrecanase" and matrix metalloproteinase cleavage of aggrecan: Application to catabolism in situ and in vitro. Biochem J 305:799-804.
29. Hutchinson NI, Lark MW, MacNaul KL, Harper C, Hoerrner LA, McDonnell J, Donatelli S, Moore V, and Bayne EK (1992). In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1 beta. Arthritis Rheum 35:1227-1233.
30. Järvinen TAH, Moilanen T, Järvinen TLN, and Moilanen E (1995). Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage. Med Inflamm 4:107-111.
31. Joyce ME, Roberts AB, Sporn MB, and Bolander ME (1990). Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110:2195-2207.
32. Kahari VM, Larjava H, and Uitto J (1991). Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture. J Biol Chem 266:10608-10615.
33. Loeser RF (1994). Modulation of integrin-mediated attachment of chondrocytes to extracellular matrix proteins by cations, retinoic acid, and transforming growth factor beta. Exp Cell Res 211:17-23.
34. Loeser RF, Carlson CS, and McGee MP (1995). Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage. Exp Cell Res 217:248-257.
35. Lohmander LS, Neame PJ, and Sandy JD (1993). The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum 36:1214-1222.
36. Lum ZP, Hakala BE, Mort JS, and Recklies AD (1996). Modulation of the catabolic effects of interleukin-1 beta on human articular chondrocytes by transforming growth factor-beta. J Cell Physiol 166:351-359.
37. Marquardt H, Lioubin MN, and Ikeda T (1987). Complete amino acid sequence of human transforming growth factor type beta 2. J Biol Chem 262:12127-12131.
38. Miossec P, Naviliat M, Dupuy A, Sany J, and Banchereau J (1990). Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis. Arthritis Rheum 33:1180-1187.
39. Mochan E and Keler T (1984). Plasmin degradation of cartilage proteoglycan. Biochim Biophys Acta 800:312-315.
40. Morales TI (1991). Transforming growth factor-beta 1 stimulates synthesis of proteoglycan aggregates in calf articular cartilage organ cultures. Arch Biochem Biophys 286:99-106.
41. Morales TI (1994). Transforming growth factor-beta and insulin-like growth factor-1 restore proteoglycan metabolism of bovine articular cartilage after depletion by retinoic acid. Arch Biochem Biophys 315:190-198.
42. Morris E (1996). Differential effects of TGF-β superfamily members on articular cartilage metabolism: Stimulation by rhBMP-9 and rhBMP-2 and inhibition by TGF-β. Trans Orthop Res Soc 42:175.
43. Mort JS, Dodge GR, Roughley PJ, Liu J, Finch SJ, DiPasquale G, and Poole AR (1993). Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage. Matrix 13:95-102.
44. Rayan V and Hardingham T (1994). The recovery of articular cartilage in explant culture from interleukin-1 alpha: Effects on proteoglycan synthesis and degradation. Matrix Biol 14: 263-271.
45. Rédini F, Galera P, Mauviel A, Loyau G, and Pujol JP (1988). Transforming growth factor beta stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes. FEBS Lett 234:172-176.
46. Rédini F, Mauviel A, Pronost S, Loyau G, and Pujol JP (1993). Transforming growth factor β exerts opposite effects from interleukin-1β on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression. Arthritis Rheum 36:44-50.
47. Roughley PJ, Melching LI, and Recklies AD (1994). Changes in the expression of decorin and biglycan in human articular cartilage with age and regulation by TGF-beta. Matrix Biol 14:51-59.
48. Saklatvala J (1986). Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature 322:547-549.
49. Schlaak JF, Pfers I, Zumbuschenfelde KHM, and Markerhermann E (1996). Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and sero-negative spondylarthropathies. Clin Exp Rheumatol 14:155-162.
50. Sellers R, Haire T, Gaskin A, and Morris E (1996). rhBMP-2 accelerated healing of full-thickness articular cartilage defects. Trans Orthop Res Soc 42:284.
51. Taskiran D, Stefanovic Racic M, Georgescu H, and Evans C (1994). Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 200:142-148.
52. Tsang ML, Zhou L, Zheng BL, Wenker J, Fransen G, Humphrey J, Smith JM, O'Connor McCourt M, Lucas R, and Weatherbee JA (1995). Characterization of recombinant soluble human transforming growth factor-beta receptor type II (rhTGF-beta sRII). Cytokine 7:389-397.
53. Tsunawaki S, Sporn M, Ding A, and Nathan C (1988). Deactivation of macrophages by transforming growth factor-beta. Nature 334:260-262.
54. van Beuningen HM, van der Kraan PM, Arntz OJ, and van den Berg WB (1993). Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: Studies in anatomically intact cartilage in vitro and in vivo. Ann Rheum Dis 52:185-191.
55. van Beuningen HM, van der Kraan PM, Arntz OJ, and van den Berg WB (1994a). Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest 71:279-290.
56. van Beuningen HM, van der Kraan PM, Arntz OJ, and van den Berg WB. (1994b). In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: Age-related differences. Ann Rheum Dis 53: 593-600.
57. van de Loo AAJ, Arntz OJ, Otterness IG, and van den Berg WB (1992). Protection against cartilage proteoglycan synthesis inhibition by anti-interleukin 1 antibodies in experimental arthritis. J Rheumatol 19:348-356.
58. van de Loo AAJ, Joosten LAB, van Lent PLEM, Arntz OJ, and van den Berg WB (1995). Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum 38:164-172.
59. van den Berg WB, Kruijsen MWM, van de Putte LBA, van Beusekom HJ, van der Sluis-van der Pol M, and Zwarts WA (1981). Antigen-induced and zymosan-induced arthritis in mice: Studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. Br J Exp Pathol 62:308-316.
60. van den Berg WB, Kruijsen MWM, and van de Putte LBA (1982). The mouse patella assay. An easy method of quantitating articular cartilage chondrocyte function in vivo and in vitro. Rheumatol Int 1:165-169.
61. van der Kraan PM, de Lange J, Vitters EL, van Beuningen HM, van Osch GJVM, van Lent PLEM, and van den Berg WB (1994). Analysis of changes in proteoglycan content in murine articular cartilage using image analysis. Osteoarthritis Cartilage 2:207-214.
62. van Meurs JB, van Lent PL, Jooster LA, van der Kraan PM, and van den Berg WB (1997). Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR. Rheumatol Int 16:197-205.
63. Vodovotz Y and Bogdan C (1994). Control of nitric oxide synthase expression by transforming growth factor-beta: Implications for homeostasis. Prog Growth Factor Res 5:341-351.
64. Vodovotz Y, Bogdan C, Paik J, Xie QW, and Nathan C (1993). Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J Exp Med 178:605-613.
65. Vogel KG and Hernandez DJ (1992). The effects of transforming growth factor-beta and serum on proteoglycan synthesis by tendon fibrocartilage. Eur J Cell Biol 59:304-313.
66. Wahl SM, Allen JB, Costa GL, Wong HL, and Dasch JR (1993). Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J Exp Med 177:225-230.