Lessons from interleukin-deficient mice: The interleukin-1 system

Acta Physiologica Scandinavica

Volumn 173, Issue 1, 2001, Pages 5-9

  Fantuzzi, G ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Arthritis; Cytokines; Endotoxin; Fever; Inflammation; Interleukin 1; Interleukin 18; Transgenic mice

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ACCESORY PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR I; INTERLEUKIN 1 RECEPTOR II; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIGAND; UNCLASSIFIED DRUG;

BINDING AFFINITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CASPASE 1; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-18; MICE; MICE, TRANSGENIC; PROTEIN KINASES; RECEPTORS, INTERLEUKIN-1; SIALOGLYCOPROTEINS;

EID: 0034792109     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2001.00879.x     Document Type: Review

References (37)

1. Hyperresponsive febrile reactions to IL-1α and IL-1β, and altered brain cytokine mRNA and serum cytokine levels, in IL-1β deficient mice
2. Inhibition of eosinophilic inflammation in allergen-challenged IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium
3. Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipolysaccharide or IL-1β: A study on IL-6-deficient mice
4. IL-1 receptor accessory protein is an essential component of the IL-1 receptor
5. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis
6. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist
7. Interleukin-18
8. Interleukin-18 and interleukin-1β: Two cytokine substrates for ICE (caspase-1)
9. Effect of endotoxin in interleukin-1β-deficient mice
10. Response to local inflammation of IL-1β converting enzyme-deficient mice
11. Interleukin-18 regulation of interferon γ production and cell proliferation as shown in interleukin-1β-converting enzyme (caspase-1)-deficient mice
12. Interleukin (IL)-12-induced interferon-gamma is dependent on caspase-1 processing of the IL-18 precursor
13. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
14. Role of IL-1 in renal ischemic reperfusion injury
15. Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice
16. Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha-beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
17. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
18. Interleukin-10-deficient mice develop chronic enterocolitis
19. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death
20. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice
21. IL-1 type I receptor mediates acute phase response to turpentine, but not lipopolysaccharide, in mice
22. Exacerbated febrile responses to LPS, but not turpentine, in TNF double receptor-knockout mice
23. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
24. Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ichemic brain damage
25. Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand
26. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
27. Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
28. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE)
29. The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
30. Interleukin-1β deficiency results in reduced NF-κB levels in pregnant mice
31. IL-6 is essential in TNF-alpha-induced fever
32. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin
33. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
34. Caspase-1-independent, Fas-Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice
35. IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1
36. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum levels of IL-18
37. Resistance to fever induction and impaired acute-phase response in interleukin-1β deficient mice